KEGG   ENZYME: 1.8.1.6Help
Entry
EC 1.8.1.6                  Enzyme                                 

Name
cystine reductase;
cystine reductase (NADH);
NADH-dependent cystine reductase;
cystine reductase (NADH2);
NADH2:L-cystine oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-cysteine:NAD+ oxidoreductase
Reaction(IUBMB)
2 L-cysteine + NAD+ = L-cystine + NADH + H+ [RN:R00892]
Reaction(KEGG)
Substrate
L-cysteine [CPD:C00097];
NAD+ [CPD:C00003]
Product
L-cystine [CPD:C00491];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.8.1.6 created 1961 as EC 1.6.4.1, transferred 2002 to EC 1.8.1.6
Pathway
Cysteine and methionine metabolism
Orthology
K05395  
cystine reductase
Reference
1  [PMID:13174550]
  Authors
ROMANO AH, NICKERSON WJ.
  Title
Cystine reductase of pea seeds and yeasts.
  Journal
J. Biol. Chem. 208 (1954) 409-16.
  Organism
Sus scofa [GN:ssc], Candida albicans [GN:cal], Pisum sativum
Reference
2  [PMID:5436160]
  Authors
Carroll JE, Kosicki GW, Thibert RJ.
  Title
Alpha-substituted cystines as possible substrates for cystine reductase and L-amino acid oxidase.
  Journal
Biochim. Biophys. Acta. 198 (1970) 601-3.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
3  [PMID:211119]
  Authors
Maresca B, Jacobson E, Medoff G, Kobayashi G.
  Title
Cystine reductase in the dimorphic fungus Histoplasma capsulatum.
  Journal
J. Bacteriol. 135 (1978) 987-92.
  Organism
Histoplasma capsulatum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-18-9

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