| Entry |
|
|---|
| Name |
glutathione-disulfide reductase;
glutathione reductase;
glutathione reductase (NADPH);
NADPH-glutathione reductase;
GSH reductase;
GSSG reductase;
NADPH-GSSG reductase;
glutathione S-reductase;
NADPH:oxidized-glutathione oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
glutathione:NADP+ oxidoreductase |
|---|
| Reaction(IUBMB) |
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
[RN:R00115] |
|---|
| Reaction(KEGG) |
R00115;
(other) R00094
 |
|---|
| Substrate |
glutathione [CPD:C00051];
NADP+ [CPD:C00006] |
|---|
| Product |
glutathione disulfide [CPD:C00127];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A dimeric flavoprotein (FAD); activity is dependent on a
redox-active disulfide in each of the active centres. |
|---|
| Pathway |
PATH: ec00480 Glutathione metabolism |
|---|
| Orthology |
KO: K00383 glutathione reductase (NADPH) |
|---|
| Genes |
HSA: 2936(GSR)
PTR: 464099(GSR)
MMU: 14782(Gsr) 630729
RNO: 116686(Gsr)
CFA: 475596(GSR)
BTA: 506406(GSR)
ECB: 100062365
MDO: 100019810
OAA: 100089169
TGU: 100223269
XLA: 447610
DRE: 553575
BFO: BRAFLDRAFT_278565
CIN: 100185545
SPU: 589396
ISC: IscW_ISCW000888
CEL: ZK637.10(trxr-2)
CBR: CBG09773
BMY: Bm1_04825
NVE: NEMVE_v1g164144
TAD: TRIADDRAFT_52087
ATH: AT3G54660(GR)
POP: POPTR_575013(PtrcGR1) POPTR_582298 POPTR_639962(PtrcGR2)
POPTR_712009
RCU: RCOM_0992190 RCOM_1020350
VVI: 100232842(GOR) 100254507(GSVIVT00020491001)
OSA: 4331112(Os02g0813500) 4331719(Os03g0163300)
SBI: SORBI_01g046260(SORBIDRAFT_01g046260)
ZMA: 100191946 100273659(gpm745b)
PPP: PHYPADRAFT_115450 PHYPADRAFT_215547
CRE: CHLREDRAFT_134165(GSHR1)
OLU: OSTLU_24082(GSR1)
CME: CMC043C
SCE: YPL091W(GLR1)
AGO: AGOS_AGR196W
KLA: KLLA0E24112g
LTH: KLTH0E13200g
DHA: DEHA0E14014g
PIC: PICST_40145(GLR2) PICST_42900(GLR1)
PPA: PAS_chr3_1011
VPO: Kpol_1048p46 Kpol_397p2
LEL: LELG_03820
ZRO: ZYRO0F14608g
CTP: CTRG_02682
CDU: CD36_50830(GLR1)
CGR: CAGL0H05665g
YLI: YALI0E18029g
SPO: SPBC17A3.07(pgr1)
NCR: NCU03339
PAN: PODANSg6451
MGR: MGG_12749
FGR: FG05183.1
ANI: AN0932.2
AFM: AFUA_1G15960
AOR: AO090005001092
ANG: An03g03660
AFV: AFLA_083370
PCS: Pc16g13280
NFI: NFIA_009340
CIM: CIMG_03087
URE: UREG_02871
SSL: SS1G_05927 SS1G_10724
BFU: BC1G_12446 BC1G_15101
CNE: CNE01560
CNB: CNBE1510
LBC: LACBIDRAFT_290991(LbGR)
MPR: MPER_09413
MGL: MGL_1130
MBR: MONBRDRAFT_38979
DDI: DDB_0231410(gsr)
PFA: PF14_0192
PFD: PFDG_01694
PFH: PFHG_03133
PYO: PY01204
PCB: PC000998.02.0
PBE: PB001317.02.0
PKN: PKH_132920
PVX: PVX_085490
TGO: TGME49_046920
TET: TTHERM_00047660 TTHERM_01222600
PTI: PHATRDRAFT_35819(Gsr_2)
TPS: THAPSDRAFT_41979 THAPS_41433
ECO: b3500(gor)
ECJ: JW3467(gor)
ECD: ECDH10B_3676(gor)
EBW: BWG_3189(gor)
ECE: Z4900(gor)
ECS: ECs4372
ECF: ECH74115_4847(gor)
ETW: ECSP_4480(gor)
ECG: E2348C_3737(gor)
ECC: c4299(gor)
ECI: UTI89_C4019(gor)
ECP: ECP_3590
ECV: APECO1_2953(gor)
ECW: EcE24377A_3982(gor)
ECX: EcHS_A3700(gor)
ECM: EcSMS35_3789(gor)
ECY: ECSE_3765
ECL: EcolC_0216
ECK: EC55989_3938(gor)
ECQ: ECED1_4169(gor)
ECR: ECIAI1_3645(gor)
ECT: ECIAI39_3990(gor)
ECZ: ECS88_3905(gor)
EUM: ECUMN_3985(gor)
ELF: LF82_0914(gor)
EBL: B21_03302(gor)
EBD: ECBD_0241
EBR: ECB_03349(gor)
EOH: ECO103_4226(gor)
EOI: ECO111_4308(gor)
EOJ: ECO26_4587(gor)
EFE: EFER_3493(gor)
STY: STY4205(gor)
STT: t3918(gor)
SPT: SPA3455(gor)
SEK: SSPA3227
SPQ: SPAB_04466
SEI: SPC_3667(gor)
SEC: SC3526(gor)
SEH: SeHA_C3911(gor)
SEE: SNSL254_A3869(gor)
SEW: SeSA_A3791(gor)
SEA: SeAg_B3803(gor)
SED: SeD_A3972(gor)
SEG: SG3840(gor)
SET: SEN3420(gor)
SES: SARI_04039
STM: STM3597(gor)
YPE: YPO3977(gor)
YPK: y3852(gor)
YPM: YP_3340(gor)
YPA: YPA_3805
YPN: YPN_3626
YPG: YpAngola_A4084(gor)
YPP: YPDSF_3342
YPS: YPTB3818(gor)
YPI: YpsIP31758_4049(gor)
YPY: YPK_0114
YPB: YPTS_4032
YEN: YE4057(gor)
SFL: SF3531(gor)
SFX: S4237(gor)
SFV: SFV_3512(gor)
SSN: SSON_3735(gor)
SBO: SBO_3498(gor)
SBC: SbBS512_E3822(gor)
SDY: SDY_3562(gor)
ECA: ECA0062(gor)
PCT: PC1_4186
PWA: Pecwa_4471
ETA: ETA_33290(gor)
PLU: plu0375(gor)
PAY: PAU_00291(gor)
SGL: SG0068
ENT: Ent638_3913
ESA: ESA_04222
CTU: Ctu_40160(gor)
KPN: KPN_03866(gor)
KPE: KPK_0241(gor)
KPU: KP1_5206(gor)
CKO: CKO_04956
SPE: Spro_4714
PMR: PMI2835(gor)
EIC: NT01EI_3741
ETR: ETAE_3367
HDE: HDEF_1909(lpd_1)
DDA: Dd703_0013
DDC: Dd586_0014
DZE: Dd1591_0014
HIN: HI0161(gor)
HIT: NTHI0251(gor)
HIP: CGSHiEE_02475
HIQ: CGSHiGG_03410
HDU: HD0354(gshR)
HAP: HAPS_1383(gor)
HSO: HS_1106(gor)
HSM: HSM_1073
PMU: PM1235(gor)
MSU: MS1985(lpd)
APL: APL_1243(gor)
APJ: APJL_1255(lpd)
APA: APP7_1293
ASU: Asuc_2024
AAP: NT05HA_2240
AAT: D11S_0445
XCC: XCC2579
XCB: XC_1539
XCA: xccb100_1582
XCV: XCV2903
XAC: XAC2750
XOM: XOO_3110
SML: Smlt3456(gor)
SMT: Smal_2883
VCH: VC0186
VCO: VC0395_A2568(gor)
VCM: VCM66_0174(gor)
VCJ: VCD_001427
VVU: VV1_1105
VVY: VV0065
VPA: VP0068
VHA: VIBHAR_00523
VSP: VS_0082
VEX: VEA_001954
VFI: VF_2489(gor)
VFM: VFMJ11_2614(gor)
VSA: VSAL_I0120(gor)
PPR: PBPRA3546
PAE: PA2025(gor)
PAU: PA14_38330(gor)
PAP: PSPA7_3263(gor)
PPU: PP_3819(gor)
PPF: Pput_1950
PPG: PputGB1_3535
PPW: PputW619_3188
PST: PSPTO_3112(gor-1) PSPTO_4254(gor-2)
PSB: Psyr_2979
PSP: PSPPH_2261(gor)
PFL: PFL_3398(gor)
PFO: Pfl01_2928
PFS: PFLU2986
PEN: PSEEN2295(gor)
PMY: Pmen_2351
PSA: PST_2113(gor)
AVN: Avin_25010(gor)
PAR: Psyc_1693(gor)
PCR: Pcryo_1966
PRW: PsycPRwf_2004
SON: SO_4702(gor)
SDN: Sden_3592
SFR: Sfri_3877
SAZ: Sama_3543
SBL: Sbal_0121
SBM: Shew185_4259
SBN: Sbal195_4395
SBP: Sbal223_4220
SLO: Shew_3660
SPC: Sputcn32_0084
SSE: Ssed_0142
SPL: Spea_4068
SHE: Shewmr4_3845
SHM: Shewmr7_3938
SHN: Shewana3_4054
SHW: Sputw3181_3981
SHL: Shal_0190
SWD: Swoo_0121
SWP: swp_4929
ILO: IL2329(gor)
CPS: CPS_4984(gor)
PHA: PSHAa0360(gor)
PAT: Patl_4206
SDE: Sde_1851
MAQ: Maqu_1359
AMC: MADE_03497
PIN: Ping_0507
TTU: TERTU_1975
LPN: lpg0578(gor)
LPF: lpl0614(gor)
LPP: lpp0630(gor)
LPC: LPC_2724(gor)
FTU: FTT_0955c(gor)
FTF: FTF0955c(gor)
FTW: FTW_0853(gor)
FTL: FTL_1248
FTH: FTH_1225(gor)
FTA: FTA_1321(gor)
FTM: FTM_0994(gor)
FTN: FTN_0834(gor)
FPH: Fphi_1780
TCX: Tcr_0140
NOC: Noc_1608
AEH: Mlg_2534
HHA: Hhal_2396
TGR: Tgr7_0127
HNA: Hneap_2174
HCH: HCH_03925(gor)
CSA: Csal_1875
ABO: ABO_1423(gor)
MMW: Mmwyl1_2363
AHA: AHA_0019(gor)
ASA: ASA_0021(gor)
AFE: Lferr_0536
AFR: AFE_0366(gor)
RMA: Rmag_0290
VOK: COSY_0276(gor)
KKO: Kkor_2548
RSO: RSc0014(gor)
RPI: Rpic_3742
RPF: Rpic12D_3419
REU: Reut_A1485 Reut_A3435
REH: H16_A3724(lpdaA)
RME: Rmet_3554
CTI: RALTA_A3180
BMA: BMA3362(gor)
BMV: BMASAVP1_A3030(gor)
BML: BMA10229_A2063(gor)
BMN: BMA10247_2222(gor)
BPS: BPSL0297(gor)
BPM: BURPS1710b_0498(gor)
BPL: BURPS1106A_0317(gor)
BPD: BURPS668_0303(gor)
BPR: GBP346_A0222(gor)
BTE: BTH_I0272(gor)
BVI: Bcep1808_3092
BUR: Bcep18194_A6352
BCN: Bcen_2392
BCH: Bcen2424_3006
BCM: Bcenmc03_3025
BCJ: BCAL0586(gor)
BAM: Bamb_3050 Bamb_6438
BAC: BamMC406_2915 BamMC406_6145
BMU: Bmul_3000
BMJ: BMULJ_00232(gor)
BGL: bglu_1g33000
BPE: BP2120(gor)
BPA: BPP1358(gor)
BBR: BB2424(gor)
BPT: Bpet1517 Bpet2923 Bpet3724
BAV: BAV1622(gor)
POL: Bpro_0643
PNA: Pnap_3544
DAC: Daci_2356
VAP: Vapar_4955
CTT: CtCNB1_0082
MPT: Mpe_A2124
MMS: mma_0966(gor)
AZO: azo0659(gor)
GBM: Gbem_3786
DMA: DMR_34990(gor)
DBA: Dbac_1885
DRT: Dret_1336
DAL: Dalk_3868
MXA: MXAN_2318(gor)
SCL: sce6561(gor)
HOH: Hoch_5726
MLO: mll0523
MES: Meso_1461
PLA: Plav_1095
SME: SMc00154(gor)
SMD: Smed_1571
ATU: Atu1611(gor)
ATC: AGR_C_2967
ARA: Arad_2684(gor)
AVI: Avi_2085(gor)
RET: RHE_CH02377(gor)
REC: RHECIAT_CH0002467(gor)
RLE: RL2694(gor)
RLT: Rleg2_2009
RLG: Rleg_2228
RHI: NGR_c17000
LAS: CLIBASIA_04785(gor)
BME: BMEI0972
BMF: BAB1_1030
BMB: BruAb1_1017(gor)
BMC: BAbS19_I09560
BMS: BR1012(gor)
BMT: BSUIS_A1055(gor)
BOV: BOV_0978(gor)
BCS: BCAN_A1027(gor)
BMR: BMI_I1014(gor)
OAN: Oant_2094
BJA: blr3757(gor)
BRA: BRADO4712(gor)
BBT: BBta_3485(gor)
RPA: RPA1983(gor)
RPB: RPB_3384
RPC: RPC_2078
RPD: RPD_2057
RPE: RPE_1989
RPT: Rpal_2196
NWI: Nwi_1223
NHA: Nham_1482
OCA: OCAR_6527(gor)
BHE: BH06430(gor)
BQU: BQ06800(gor)
BBK: BARBAKC583_0604(gor)
BTR: Btr_0935(gor)
BGR: Bgr_07280(gor)
XAU: Xaut_0796 Xaut_2904 Xaut_3224
AZC: AZC_2334
MEX: Mext_2301
MEA: Mex_1p2302(gor) Mex_1p2630
MDI: METDI3083(gor)
MRD: Mrad2831_2696
MET: M446_4780
MPO: Mpop_2257
MCH: Mchl_2576
MNO: Mnod_4666
BID: Bind_0881
MSL: Msil_0122
CCR: CC_2302
CCS: CCNA_02387
CAK: Caul_3544
PZU: PHZ_c1498 PHZ_c1988(gor)
SIL: SPO1328(gor)
SIT: TM1040_1957
RSP: RSP_0358(gor)
RSH: Rsph17029_2002
RSQ: Rsph17025_0884
RSK: RSKD131_1687
RDE: RD1_1919(gor)
PDE: Pden_3669
DSH: Dshi_2737(gor)
MMR: Mmar10_0973
HNE: HNE_0707(gor)
HBA: Hbal_1850
ZMO: ZMO1211
ZMN: Za10_0122
NAR: Saro_1810
SAL: Sala_1216
SWI: Swit_2722
ELI: ELI_04880
GOX: GOX1764
GBE: GbCGDNIH1_1427
ACR: Acry_1981
GDI: GDI_2216(gor)
GDJ: Gdia_0434
APT: APA01_01050
RRU: Rru_A0682
RCE: RC1_1589(gor)
MAG: amb1666
SEP: SE0080 SE2184
SER: SERP2195
SHA: SH0217
SSP: SSP1636
LMO: lmo0906 lmo1433
LMF: LMOf2365_0928(gor) LMOf2365_1452
LMH: LMHCC_1135 LMHCC_1716(gor)
LMC: Lm4b_00926 Lm4b_01443
LIN: lin0906 lin1472
LWE: lwe0891 lwe1450
ESI: Exig_2162
EAT: EAT1b_2623
MCL: MCCL_1686
LLA: L0197(gshR)
LLK: LLKF_0859(gshR)
LLC: LACR_0912
LLM: llmg_1702(gshR) llmg_2331
SPY: SPy_0813(gor)
SPZ: M5005_Spy_0627(gor)
SPM: spyM18_0875(gshR)
SPG: SpyM3_0546(gor)
SPS: SPs1308
SPH: MGAS10270_Spy0683(gor)
SPI: MGAS10750_Spy0715(gor)
SPJ: MGAS2096_Spy0692(gor)
SPK: MGAS9429_Spy0682(gor)
SPF: SpyM51180(gor)
SPA: M6_Spy0644
SPB: M28_Spy0607(gor)
SOZ: Spy49_0637(gor)
SPN: SP_0784
SPD: SPD_0685(gor)
SPR: spr0692(gor)
SPW: SPCG_0733(gor)
SPX: SPG_0714(gor)
SNE: SPN23F_07100(gor)
SPV: SPH_0883(gor)
SNM: SP70585_0827(gor)
SJJ: SPJ_0726(gor)
SPP: SPP_0793(gor)
SNT: SPT_1416(gor)
SAG: SAG1375(gor)
SAN: gbs1445
SAK: SAK_1408(gor)
SMU: SMU.140 SMU.838(gshR)
STC: str0408(gor)
STL: stu0408(gor)
STE: STER_0447
SSA: SSA_1533(gor)
SSV: SSU98_0504
SSB: SSUBM407_0451(gor)
SSI: SSU0464(gor)
SSS: SSUSC84_0448(gor)
SGO: SGO_0749
SEQ: SZO_10950
SEZ: Sez_0867
SEU: SEQ_0994
SUB: SUB0719(gor)
SDS: SDEG_0778(gor)
LPL: lp_0369(gshR1) lp_1253(gshR2) lp_1822(gshR3) lp_3267(gshR4)
LPJ: JDM1_0331(gshR1) JDM1_1060(gshR2) JDM1_1535(gshR3)
JDM1_2620(gshR4)
LJO: LJ0042
LJF: FI9785_107(gshR)
LAC: LBA1107
LSA: LSA1871(gshR)
LSL: LSL_2028
LBR: LVIS_0434 LVIS_2051
LCA: LSEI_2187 LSEI_2627
LCB: LCABL_23620(gshR) LCABL_27950(gshR)
LGA: LGAS_0040
LRE: Lreu_1411
LRF: LAR_1327
LHE: lhv_1217
LFE: LAF_1615
LRH: LGG_02615(gshR)
LRL: LC705_02619(gshR)
EFA: EF3270(gor)
OOE: OEOE_1191
LME: LEUM_0806 LEUM_0947 LEUM_1019
LCI: LCK_00130(gshR1) LCK_00450(gshR2) LCK_00805(gshR3)
LCK_p300013(gshR5)
MTU: Rv2855(mtr)
MTC: MT2922
MRA: MRA_2878(mtr)
MTF: TBFG_12870
MTB: TBMG_01117(TBMG_01117.1)
MBO: Mb2880(mtr)
MBB: BCG_2875(mtr)
MBT: JTY_2870(mtr)
MPA: MAP2923(gorA)
MAV: MAV_3710
MSM: MSMEG_2611
MVA: Mvan_2298
MGI: Mflv_4054
MAB: MAB_0062 MAB_p09
MMC: Mmcs_2067
MKM: Mkms_2113
MJL: Mjls_2050
MMI: MMAR_1875(mtr) MMAR_p09
CGL: NCgl1928(cgl2003)
CGB: cg2194(gor)
CGT: cgR_1832
CEF: CE1896
CDI: DIP1494
CJK: jk1153(gorA)
CUR: cur_0840(mtr)
CAR: cauri_1543(mtr)
CKP: ckrop_1156
RHA: RHA1_ro06610
RER: RER_26020(mtr)
ROP: ROP_66450(mtr)
GBR: Gbro_2130
SMA: SAV_2154(lpdA2)
TWS: TW646(pdhD)
CMS: CMS_1352
AAU: AAur_1942
ACH: Achl_1643
RSA: RSal33209_2968
MLU: Mlut_13800
BCV: Bcav_1086
BFA: Bfae_09170
KSE: Ksed_08580
PAC: PPA0333
NCA: Noca_1648
NML: Namu_2195
SEN: SACE_5978(mtr)
SVI: Svir_10080
AMI: Amir_5878
CAI: Caci_3488
ACA: ACP_1229
GFO: GFO_1323(gor) GFO_3156(gor)
RBI: RB2501_04890
RBA: RB4396
SYW: SYNW1533(gshR)
SYC: syc0698_d(gor)
SYF: Synpcc7942_0842
SYD: Syncc9605_0976
SYE: Syncc9902_0889
SYG: sync_1931
SYR: SynRCC307_1202(gor)
SYX: SynWH7803_0706(gor)
TEL: tll1608
MAR: MAE_46260
CYT: cce_4626(gor)
CYP: PCC8801_0404
CYC: PCC7424_4332
CYN: Cyan7425_3289
CYH: Cyan8802_0414
GVI: gll4201
ANA: all4968(gor)
NPU: Npun_R0901
AVA: Ava_2244
PMA: Pro0569(gor)
PMM: PMM0567(gshR)
PMT: PMT0470(gshR)
PMN: PMN2A_0003
PMI: PMT9312_0567
PMB: A9601_06231(gor)
PMC: P9515_06311(gor)
PMF: P9303_18091(gor)
PMG: P9301_05931(gor)
PMH: P9215_06481(gor)
PMJ: P9211_05711(gor)
PME: NATL1_06221(gor)
TER: Tery_4747
AMR: AM1_3681(gor)
MAC: MA1019 MA4013(gor)
MBA: Mbar_A0570
MMA: MM_0897
MEM: Memar_0358
MPL: Mpal_0666
 |
|---|
| Structures |
PDB: 1ONF 2AAQ 2GH5 2HQM 3DJG 3DJJ 3DK4 3DK8 3DK9 |
|---|
Reference
Authors
Title
Journal
|
1
Pai, E.F., Schirmer, R.H. and Schulz, G.E.
Structural studies on crystalline glutathione reductase from human
erythrocytes.
In: Singer, T.P. and Ondarza, R.N. (Eds.), Mechanisms of Oxidizing
Enzymes, Mechanisms of Oxidizing Enzymes, New York, 1978, p. 17-22. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:330529]
Pigiet VP, Conley RR.
Purification of thioredoxin, thioredoxin reductase, and glutathione
reductase by affinity chromatography.
J. Biol. Chem. 252 (1977) 6367-72.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13271446]
RACKER E.
Glutathione reductase from bakers' yeast and beef liver.
J. Biol. Chem. 217 (1955) 855-65.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13032091]
VAN HEYNINGEN R, PIRIE A.
Reduction of glutathione coupled with oxidative decarboxylation of
malate in cattle lens.
Biochem. J. 53 (1953) 436-44.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:9277]
Worthington DJ, Rosemeyer MA.
Glutathione reductase from human erythrocytes. Catalytic properties
and aggregation.
Eur. J. Biochem. 67 (1976) 231-8.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:10969088]
Bohme CC, Arscott LD, Becker K, Schirmer RH, Williams CH Jr.
Kinetic characterization of glutathione reductase from the malarial
parasite Plasmodium falciparum. Comparison with the human enzyme.
J. Biol. Chem. 275 (2000) 37317-23.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:1524433]
Libreros-Minotta CA, Pardo JP, Mendoza-Hernandez G, Rendon JL.
Purification and characterization of glutathione reductase from
Rhodospirillum rubrum.
Arch. Biochem. Biophys. 298 (1992) 247-53.
Rhodospirillum rubrum [GN:rru] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.8.1.7
IUBMB Enzyme Nomenclature: 1.8.1.7
ExPASy - ENZYME nomenclature database: 1.8.1.7
BRENDA, the Enzyme Database: 1.8.1.7
CAS: 9001-48-3 |
|---|
