KEGG   ENZYME: 1.8.4.2Help
Entry
EC 1.8.4.2                  Enzyme                                 
Name
protein-disulfide reductase (glutathione);
glutathione-insulin transhydrogenase;
insulin reductase;
reductase, protein disulfide (glutathione);
protein disulfide transhydrogenase;
glutathione-protein disulfide oxidoreductase;
protein disulfide reductase (glutathione);
GSH-insulin transhydrogenase;
protein-disulfide interchange enzyme;
protein-disulfide isomerase/oxidoreductase;
thiol:protein-disulfide oxidoreductase;
thiol-protein disulphide oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
glutathione:protein-disulfide oxidoreductase
Reaction(IUBMB)
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol [RN:R03915]
Reaction(KEGG)
R03915;
(other) R02824
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Substrate
glutathione [CPD:C00051];
protein disulfide [CPD:C02582]
Product
glutathione disulfide [CPD:C00127];
protein dithiol [CPD:C02315]
Comment
Reduces insulin and some other proteins.
Pathway
Glutathione metabolism
Orthology
K05360  
protein-disulfide reductase (glutathione)
Genes
HSA: 
51060(TXNDC12)
PTR: 
100610643(TXNDC12)
PPS: 
100996005(TXNDC12)
GGO: 
101134035(TXNDC12)
MCC: 
712891(TXNDC12) 713426(TXNDC12)
MMU: 
66073(Txndc12)
RNO: 
298370(Txndc12)
CFA: 
609843(TXNDC12)
AML: 
FCA: 
101089631(TXNDC12)
BTA: 
506991(TXNDC12)
SSC: 
100517534
ECB: 
100062254
OAA: 
100078583
GGA: 
772208(TXNDC12)
MGP: 
100541059
ACS: 
100562080
XLA: 
380448(tlp19)
XTR: 
100379783(txndc12)
DRE: 
324900(txndc12)
TRU: 
101067813
OLA: 
101170372
BFO: 
BRAFLDRAFT_127172
SPU: 
586825
AME: 
100577311
PHU: 
Phum_PHUM562500
TSP: 
Tsp_10270
NVE: 
NEMVE_v1g163663
TAD: 
TRIADDRAFT_59397
MBR: 
MONBRDRAFT_37391
 » show all
Taxonomy
Reference
1  [PMID:14031343]
  Authors
KATZEN HM, TIETZE F, STETTEN D Jr.
  Title
Further studies on the properties of hepatic glutathione-insulin transhydro-genase.
  Journal
J. Biol. Chem. 238 (1963) 1006-11.
  Organism
Bos taurus [GN:bta]
Reference
2
  Authors
Kohnert, K.-D., Hahn, H.-J., Zuhlke, H., Schmidt, S. and Fiedler, H.
  Title
Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro.
  Journal
Biochim. Biophys. Acta 338 (1974) 68-77.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9082-53-5
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