| Entry |
|
|---|
| Name |
enzyme-thiol transhydrogenase (glutathione-disulfide);
[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase;
enzyme-thiol transhydrogenase (oxidized-glutathione);
glutathione-dependent thiol:disulfide oxidoreductase;
thiol:disulphide oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
 |
|---|
| Sysname |
[xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase |
|---|
| Reaction(IUBMB) |
[xanthine dehydrogenase] + glutathione disulfide = [xanthine
oxidase] + 2 glutathione [RN:R04039] |
|---|
| Reaction(KEGG) |
R04039
 |
|---|
| Substrate |
[xanthine dehydrogenase] [CPD:C03544];
glutathione disulfide [CPD:C00127] |
|---|
| Product |
[xanthine oxidase] [CPD:C02756];
glutathione [CPD:C00051] |
|---|
| Comment |
Converts EC 1.17.1.4 xanthine dehydrogenase into EC 1.17.3.2
xanthine oxidase in the presence of glutathione disulfide; also
reduces the disulfide bond of ricin. Not inhibited by Cu2+ or thiol
reagents. |
|---|
| Pathway |
PATH: ec00480 Glutathione metabolism |
|---|
| Structures |
PDB: 3FKF |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6960894]
Battelli MG, Lorenzoni E.
Purification and properties of a new glutathione-dependent
thiol:disulphide oxidoreductase from rat liver.
Biochem. J. 207 (1982) 133-8.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.8.4.7
IUBMB Enzyme Nomenclature: 1.8.4.7
ExPASy - ENZYME nomenclature database: 1.8.4.7
BRENDA, the Enzyme Database: 1.8.4.7
CAS: 85030-79-1 |
|---|
