KEGG   ENZYME: 2.1.1.10Help
Entry
EC 2.1.1.10                 Enzyme                                 
Name homocysteine S-methyltransferase;
S-adenosylmethionine homocysteine transmethylase;
S-methylmethionine homocysteine transmethylase;
adenosylmethionine transmethylase;
methylmethionine:homocysteine methyltransferase;
adenosylmethionine:homocysteine methyltransferase;
homocysteine methylase;
homocysteine methyltransferase;
homocysteine transmethylase;
L-homocysteine S-methyltransferase;
S-adenosyl-L-methionine:L-homocysteine methyltransferase;
S-adenosylmethionine-homocysteine transmethylase;
S-adenosylmethionine:homocysteine methyltransferase
Class Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname S-adenosyl-L-methionine:L-homocysteine S-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine
+ L-methionine [RN:R00650]
Reaction(KEGG) R00650
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Substrate S-adenosyl-L-methionine [CPD:C00019];
L-homocysteine [CPD:C00155]
Product S-adenosyl-L-homocysteine [CPD:C00021];
L-methionine [CPD:C00073]
Comment The bacterial enzyme uses S-methylmethionine as donor more actively
than S-adenosylmethionine.
Pathway PATH: ec00270  Cysteine and methionine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00547  homocysteine S-methyltransferase
Genes XTR: 394486
DRE: 100141349 337599
BFO: BRAFLDRAFT_114091
SPU: 587964
DPO: Dpse_GA10443
AME: 725816
TCA: 662176
NVE: NEMVE_v1g107735
TAD: TRIADDRAFT_60203
ATH: AT3G22740(HMT3) AT3G25900(HMT-1) AT3G63250(HMT2)
POP: POPTR_559589(HMT5) POPTR_658494(HMT2) POPTR_822134(HMT4)
VVI: 100247323(GSVIVT00030336001)
OSA: 4324713(Os01g0772900) 4332095(Os03g0221200)
     4348656(Os10g0422200)
AGO: AGOS_AFR410W
DHA: DEHA0A00869g
PIC: PICST_30270(SAM4)
YLI: YALI0F25641g
NCR: NCU00799
MGR: MGG_04215
ANI: AN3378.2
AFM: AFUA_5G01500
AOR: AO090010000103
ANG: An15g07110
CNE: CNJ02520
UMA: UM01787.1
TET: TTHERM_00637220
TBR: Tb927.1.1270
TCR: 506479.120 508993.20
LMA: LmjF36.6310
ECO: b0261(mmuM)
ECJ: JW0253(mmuM)
ECD: ECDH10B_0247(mmuM)
ECA: ECA2797(mmuM)
ENT: Ent638_0828(mmuM)
ESA: ESA_02943(mmuM)
KPN: KPN_00310(mmuM)
KPE: KPK_4378(mmuM)
KPU: KP1_1168(mmuM)
CKO: CKO_02822(mmuM)
SPE: Spro_3471(mmuM)
XCC: XCC1344(mmuM)
XCB: XC_2894(mmuM)
XCA: xccb100_2952(mmuM)
XCV: XCV1449(mmuM)
XAC: XAC1392(mmuM)
XOO: XOO1930(mmuM)
XOM: XOO_1828(mmuM)
XOP: PXO_01795(mmuM)
PFO: Pfl01_2779
SAZ: Sama_0417
PIN: Ping_2160
AHA: AHA_2807
GSU: GSU2974
GME: Gmet_0504
GUR: Gura_0708
GBM: Gbem_0613
GEO: Geob_0913
PCA: Pcar_0238
PPD: Ppro_0283
MXA: MXAN_6160
SCL: sce8634
SAT: SYN_00176
PUB: SAR11_0750(mmuM)
RET: RHE_PC00163(ypc00089)
RLE: RL1357
JAN: Jann_3671
RDE: RD1_0018 RD1_3753
GBE: GbCGDNIH1_1976(mmuM)
BSU: BSU02410(ybgG) BSU11010(yitJ)
BHA: BH1629
BCE: BC4251
BCZ: BCZK4006(metE)
BCY: Bcer98_2984
BTK: BT9727_3996(metE)
BTL: BALH_3851(metE)
BWE: BcerKBAB4_5466(mmuM)
BLI: BL01307(yitJ) BL01781(mmuM)
BLD: BLi00266(mmuM) BLi01193(yitJ)
BAY: RBAM_002780(mmuM) RBAM_011020(yitJ)
BPU: BPUM_0224(mmuM) BPUM_1027(yitJ)
GKA: GK0717
GTN: GTNG_0622
AFL: Aflv_2165
SAU: SA0345
SAV: SAV0357
SAW: SAHV_0354
SAM: MW0333
SAR: SAR0354
SAS: SAS0333
SAC: SACOL0429
SAB: SAB0307c(metE2)
SAA: SAUSA300_0358
SAX: USA300HOU_0378
SAO: SAOUHSC_00339
SAJ: SaurJH9_0405
SAH: SaurJH1_0415
SAE: NWMN_0349(metH)
SEP: SE2381
SER: SERP0035
SHA: SH2637
SSP: SSP2172(mmuM) SSP2415
LMO: lmo1678
LMF: LMOf2365_1702
LMH: LMHCC_0888
LIN: lin1786
LWE: lwe1696
LSP: Bsph_0175
ESI: Exig_2991(mmuM)
MCL: MCCL_0330
BBE: BBR47_30220(ybgG)
SAG: SAG1305(mmuM) SAG2048
SAN: gbs1377(mmuM) gbs2004
SAK: SAK_1337(mmuM) SAK_1987
SMU: SMU.874 SMU.952(mmuM)
STC: str0584(mmuM)
STL: stu0584(mmuM)
STE: STER_0628(mmuM)
SSA: SSA_1096(mmuM)
SSU: SSU05_2024(mmuM)
SSV: SSU98_2025(mmuM)
LPL: lp_1298(mmuM)
LAC: LBA1003(mmuM)
LSL: LSL_1692(mmuM)
LDB: Ldb0311(mmuM)
LBU: LBUL_0268(mmuM)
LRE: Lreu_1042(mmuM)
LRF: LAR_0993(mmuM)
LHE: lhv_1172(mmuM)
LFE: LAF_0828(mmuM)
LCI: LCK_00551(mmuM)
CAC: CAC3348(mmuM)
CKL: CKL_2259(mmuM)
CKR: CKR_1988
ATE: Athe_0325
EEL: EUBELI_01283
CSC: Csac_1165
MTU: Rv2458(mmuM)
MTC: MT2533(mmuM)
MRA: MRA_2484(mmuM)
MTF: TBFG_12483(mmuM)
MTB: TBMG_01515(TBMG_01515.1)
MBO: Mb2485(mmuM)
MBB: BCG_2478(mmuM)
MBT: JTY_2472(mmuM)
MLE: ML1478(mmuM)
MLB: MLBr_01478
MPA: MAP2279(mmuM)
MAV: MAV_1715(mmuM)
CAR: cauri_0617(mmuM)
SCO: SCO6137(mmuM)
SMA: SAV_2111(mmuM)
SGR: SGR_1576(mmuM)
CMI: CMM_2830(mmuM)
CMS: CMS_2974(mmuM)
AAU: AAur_3089(mmuM)
ACH: Achl_1146
SEN: SACE_3890(mmuM)
BAD: BAD_0986(mmuM)
RXY: Rxyl_0843
ABA: Acid345_3426
SUS: Acid_7115
MIN: Minf_1622(metF)
CAU: Caur_3087(mmuM)
CAG: Cagg_0866
CHL: Chy400_3335
HAU: Haur_3632
TRO: trd_1049
Taxonomy
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:4861151]
Balish E, Shapiro SK.
Methionine biosynthesis in Escherichia coli: induction and
repression of methylmethionine(or adenosylmethionine):homocysteine
methyltransferase.
Arch. Biochem. Biophys. 119 (1967) 62-8.
Escherichia coli [GN:eco]
Reference
  Authors
  Title
  Journal
  Organism

 2  [PMID:13572358]
SHAPIRO SK.
Adenosylmethioninehomocysteine transmethylase.
Biochim. Biophys. Acta. 29 (1958) 405-9.
Saccharomyces cerevisiae [GN:sce], Escherichia coli [GN:eco],
Klebsiella pneumoniae [GN:kpn], Torulopsis utilis
Reference
  Authors
  Title

  Journal
  Organism

 3  [PMID:14445542]
SHAPIRO SK, YPHANTIS DA.
Assay of S-methylmethionine and S-adenosylmethionine homocysteine
transmethylases.
Biochim. Biophys. Acta. 36 (1959) 241-4.
Saccharomyces cerevisiae [GN:sce], Escherichia coli [GN:eco],
Klebsiella pneumoniae [GN:kpn]
Other DBs ExplorEnz - The Enzyme Database: 2.1.1.10
IUBMB Enzyme Nomenclature: 2.1.1.10
ExPASy - ENZYME nomenclature database: 2.1.1.10
BRENDA, the Enzyme Database: 2.1.1.10
CAS: 9012-40-2
DBGET integrated database retrieval system