KEGG   ENZYME: 2.1.1.113Help
Entry
EC 2.1.1.113                Enzyme                                 

Name
site-specific DNA-methyltransferase (cytosine-N4-specific);
modification methylase;
restriction-modification system;
DNA[cytosine-N4]methyltransferase;
m4C-forming MTase;
S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine [RN:R03003]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
DNA cytosine [CPD:C00856]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
DNA N4-methylcytosine [CPD:C03110]
Comment
This is a large group of enzymes, most of which, with enzymes of similar site specificity listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease), form so-called 'restriction-modification systems'. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase.neb.com/rebase/rebase.html.
History
EC 2.1.1.113 created 1992
Orthology
K00590  
site-specific DNA-methyltransferase (cytosine-N4-specific)
Genes
ECV: 
ELO: 
SETC: 
SPT: 
SPA4289(hsdM)
SEK: 
SEA: 
SENS: 
SEEC: 
SEEB: 
PWA: 
ECLE: 
ECLY: 
ECLZ: 
EAR: 
KPZ: 
KPX: 
KOK: 
CFD: 
XNE: 
XNM: 
PANT: 
PANP: 
KIN: 
XCV: 
VCY: 
ABM: 
TIG: 
TVI: 
TGR: 
RPF: 
REH: 
CTI: 
BPM: 
BTE: 
BVI: 
BGD: 
BYI: 
AXY: 
RFR: 
POL: 
AAV: 
DIA: 
VEI: 
MPT: 
NIT: 
MEI: 
HPY: 
HAC: 
DGG: 
SAT: 
HMR: 
WCL: 
MES: 
MEA: 
TXI: 
SGO: 
FRA: 
LIL: 
CTM: 
CYT: 
CYC: 
CYJ: 
HAO: 
GLP: 
ONI: 
GLJ: 
GKIL_4476(ccrM)
ANA: 
NOS: 
NOP: 
AVA: 
ANB: 
ACY: 
CSG: 
CALO: 
CALT: 
RIV: 
CTHE: 
SCS: 
BFR: 
NSO: 
CPH: 
CPB: 
CLI: 
PPH: 
CAG: 
ATM: 
MRB: 
MRE: 
PMO: 
CCZ: 
FSI: 
MJA: 
MCJ: 
MHI: 
RCI: 
HAL: 
HMA: 
HXA: 
NOU: 
SAI: 
 » show all
Taxonomy
Reference
1  [PMID:2172084]
  Authors
Kessler C, Manta V.
  Title
Specificity of restriction endonucleases and DNA modification methyltransferases a review (Edition 3).
  Journal
Gene. 92 (1990) 1-248.
Reference
2  [PMID:2690010]
  Authors
Klimasauskas S, Timinskas A, Menkevicius S, Butkiene D, Butkus V, Janulaitis A.
  Title
Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases.
  Journal
Nucleic. Acids. Res. 17 (1989) 9823-32.
  Sequence
Reference
3  [PMID:2159140]
  Authors
Roberts RJ.
  Title
Restriction enzymes and their isoschizomers.
  Journal
Nucleic. Acids. Res. 18 Suppl (1990) 2331-65.
Reference
4  [PMID:6267988]
  Authors
Yuan R.
  Title
Structure and mechanism of multifunctional restriction endonucleases.
  Journal
Annu. Rev. Biochem. 50 (1981) 285-319.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
169592-50-1

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