| Entry |
|
|---|
| Name |
3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine
4'-O-methyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine =
S-adenosyl-L-homocysteine + (S)-reticuline [RN:R03832] |
|---|
| Reaction(KEGG) |
R03832;
(other) R05212
 |
|---|
| Substrate |
S-adenosyl-L-methionine [CPD:C00019];
3'-hydroxy-N-methyl-(S)-coclaurine [CPD:C05202] |
|---|
| Product |
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-reticuline [CPD:C02105] |
|---|
| Comment |
Involved in isoquinoline alkaloid metabolism in plants. The enzyme
has also been shown to catalyse the methylation of
(RS)-laudanosoline, (S)-3'-hydroxycoclaurine and
(RS)-7-O-methylnorlaudanosoline. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K13386 3'-hydroxy-N-methyl-(S)-coclaurine
4'-O-methyltransferase |
|---|
Reference
Authors
Title
Journal
|
1
Frenzel, T., Zenk, M.H.
S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine
4'-O-methyltransferase, a regio- and stereoselective enzyme of the
(S)-reticuline pathway.
Phytochemistry 29 (1990) 3505-3511. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.1.116
IUBMB Enzyme Nomenclature: 2.1.1.116
ExPASy - ENZYME nomenclature database: 2.1.1.116
BRENDA, the Enzyme Database: 2.1.1.116
CAS: 132084-81-2 |
|---|
