| Entry |
|
|---|
| Name |
columbamine O-methyltransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:columbamine O-methyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine +
palmatine [RN:R03721] |
|---|
| Reaction(KEGG) |
R03721
 |
|---|
| Substrate |
S-adenosyl-L-methionine [CPD:C00019];
columbamine [CPD:C01795] |
|---|
| Product |
S-adenosyl-L-homocysteine [CPD:C00021];
palmatine [CPD:C05315] |
|---|
| Comment |
The product of this reaction is a protoberberine alkaloid that is
widely distributed in the plant kingdom. This enzyme is distinct in
specificity from EC 2.1.1.88, 8-hydroxyquercetin
8-O-methyltransferase. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis |
|---|
| Orthology |
KO: K13398 columbamine O-methyltransferase |
|---|
Reference
Authors
Title
Journal
|
1
Rueffer, M., Amann, M., Zenk, M.H.
S-Adenosyl-L-methionine:columbamine O-methyltransferase, a
compartmentalized enzyme in protoberberine biosynthesis.
Plant Cell Reports 3 (1986) 182-185. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.1.118
IUBMB Enzyme Nomenclature: 2.1.1.118
ExPASy - ENZYME nomenclature database: 2.1.1.118
BRENDA, the Enzyme Database: 2.1.1.118
CAS: 105843-76-3 |
|---|
