| Entry |
|
|---|
| Name |
(S)-coclaurine-N-methyltransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine
+ (S)-N-methylcoclaurine [RN:R04692] |
|---|
| Reaction(KEGG) |
R04692
 |
|---|
| Substrate |
S-adenosyl-L-methionine [CPD:C00019];
(S)-coclaurine [CPD:C06161] |
|---|
| Product |
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-N-methylcoclaurine [CPD:C05176] |
|---|
| Comment |
The enzyme is specific for the (S)-isomer of coclaurine.
Norcoclaurine can also act as an acceptor. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K13384 (S)-coclaurine N-methyltransferase |
|---|
Reference
Authors
Title
Journal
|
1
Loeffler, S., Deus-Neumann, B. and Zenk, M.H.
S-Adenosyl-L-methionine: (S)-coclaurine-N-methyltransferase from
Tinospora cordifolia.
Phytochemistry 38 (1995) 1387-1395. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.1.140
IUBMB Enzyme Nomenclature: 2.1.1.140
ExPASy - ENZYME nomenclature database: 2.1.1.140
BRENDA, the Enzyme Database: 2.1.1.140
CAS: 167398-06-3 |
|---|
