| Entry |
|
|---|
| Name |
guanidinoacetate N-methyltransferase;
GA methylpherase;
guanidinoacetate methyltransferase;
guanidinoacetate transmethylase;
methionine-guanidinoacetic transmethylase;
guanidoacetate methyltransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + guanidinoacetate =
S-adenosyl-L-homocysteine + creatine [RN:R01883] |
|---|
| Reaction(KEGG) |
R01883
 |
|---|
| Substrate |
S-adenosyl-L-methionine [CPD:C00019];
guanidinoacetate [CPD:C00581] |
|---|
| Product |
S-adenosyl-L-homocysteine [CPD:C00021];
creatine [CPD:C00300] |
|---|
| Pathway |
PATH: ec00260 Glycine, serine and threonine metabolism
PATH: ec00330 Arginine and proline metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00542 guanidinoacetate N-methyltransferase |
|---|
| Genes |
HSA: 2593(GAMT)
PTR: 749982(GAMT)
MCC: 721263
MMU: 14431(Gamt)
RNO: 25257(Gamt)
CFA: 485085(GAMT)
BTA: 515270(GAMT)
ECB: 100068840
MDO: 100015231
GGA: 770737(GAMT)
XLA: 380384(gamt)
XTR: 394491(gamt)
DRE: 796865(gamt)
NVE: NEMVE_v1g89249
DHA: DEHA0E20339g
PIC: PICST_66076(RMT2)
FAL: FRAAL4941
 |
|---|
| Structures |
PDB: 1KHH 1P1B 1P1C 1XCJ 1XCL 1ZX0 2BLN |
|---|
Reference
Authors
Title
Journal
|
1
Cantoni, G.L. and Scarano, E.
The formation of S-adenosylhomocysteine in enzymatic
transmethylation reactions.
J. Am. Chem. Soc. 76 (1954) 4744. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13192118]
CANTONI GL, VIGNOS PJ Jr.
Enzymatic mechanism of creatine synthesis.
J. Biol. Chem. 209 (1954) 647-59.
Bos taurus [GN:bta], Sus scofa [GN:ssc], Cavia porcellus,
Oryctolagus cuniculus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.1.2
IUBMB Enzyme Nomenclature: 2.1.1.2
ExPASy - ENZYME nomenclature database: 2.1.1.2
BRENDA, the Enzyme Database: 2.1.1.2
CAS: 9029-75-8 |
|---|
