KEGG   ENZYME: 2.1.1.247Help
Entry
EC 2.1.1.247                Enzyme                                 

Name
[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase;
methyltransferase 2 (ambiguous);
MT2 (ambiguous);
MT2-A;
mtbA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
methylated monomethylamine-specific corrinoid protein:coenzyme M methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methylamine-specific corrinoid protein] [RN:R10000]
Reaction(KEGG)
Substrate
[methyl-Co(III) methylamine-specific corrinoid protein];
coenzyme M [CPD:C03576]
Product
methyl-CoM [CPD:C03920];
[Co(I) methylamine-specific corrinoid protein]
Comment
Contains zinc [2]. The enzyme, which is involved in methanogenesis from mono-, di-, and trimethylamine, catalyses the transfer of a methyl group bound to the cobalt cofactor of several corrinoid proteins (mono-, di-, and trimethylamine-specific corrinoid proteins, cf. EC 2.1.1.248, methylamine---corrinoid protein Co-methyltransferase, EC 2.1.1.249, dimethylamine---corrinoid protein Co-methyltransferase, and EC 2.1.1.250, trimethylamine---corrinoid protein Co-methyltransferase) to coenzyme M, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis.
History
EC 2.1.1.247 created 2012
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Orthology
K14082  
[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase
Genes
MAC: 
MA0146(mtbA)
MBA: 
MMA: 
MM_1439(mtbA)
MMAZ: 
MBU: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
Taxonomy
Reference
1  [PMID:7635826]
  Authors
Burke SA, Krzycki JA
  Title
Involvement of the "A" isozyme of methyltransferase II and the 29-kilodalton corrinoid protein in methanogenesis from monomethylamine.
  Journal
J. Bacteriol. 177 (1995) 4410-6.
  Sequence
Reference
2  [PMID:8702528]
  Authors
LeClerc GM, Grahame DA
  Title
Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression.
  Journal
J. Biol. Chem. 271 (1996) 18725-31.
  Sequence
Reference
3  [PMID:9006042]
  Authors
Ferguson DJ Jr, Krzycki JA
  Title
Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri.
  Journal
J. Bacteriol. 179 (1997) 846-52.
  Sequence
Reference
4  [PMID:9642198]
  Authors
Burke SA, Lo SL, Krzycki JA
  Title
Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.
  Journal
J. Bacteriol. 180 (1998) 3432-40.
  Sequence
Reference
5  [PMID:10852929]
  Authors
Ferguson DJ Jr, Gorlatova N, Grahame DA, Krzycki JA
  Title
Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.
  Journal
J. Biol. Chem. 275 (2000) 29053-60.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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