| Entry |
|
|---|
| Name |
phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + phenylethanolamine =
S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN:R04033] |
|---|
| Reaction(KEGG) |
R04033;
(other) R02533
 |
|---|
| Substrate |
S-adenosyl-L-methionine [CPD:C00019];
phenylethanolamine [CPD:C02735] |
|---|
| Product |
S-adenosyl-L-homocysteine [CPD:C00021];
N-methylphenylethanolamine [CPD:C03711] |
|---|
| Comment |
Acts on various phenylethanolamines; converts noradrenaline into
adrenaline. |
|---|
| Pathway |
PATH: ec00350 Tyrosine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00553 phenylethanolamine N-methyltransferase |
|---|
| Genes |
HSA: 5409(PNMT)
PTR: 454634(PNMT)
MCC: 697444(PNMT)
MMU: 18948(Pnmt)
RNO: 24661(Pnmt)
CFA: 491023(PNMT)
BTA: 281413(PNMT)
SSC: 100144479(PNMT)
ECB: 100033859(PNMT)
MDO: 100017260
OAA: 100079586
GGA: 776803(PNMT)
 |
|---|
| Structures |
PDB: 1HNN 1N7I 1N7J 1YZ3 2AN3 2AN4 2AN5 2G70 2G71 2G72
2G8N 2OBF 2ONY 2ONZ 2OPB 3HCA 3HCB 3HCC 3HCD 3HCE
3HCF |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13863458]
AXELROD J.
Purification and properties of phenylethanolamine-N-methyl
transferase.
J. Biol. Chem. 237 (1962) 1657-60.
Macaca mulatta [GN:mcc] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5412063]
Connett RJ, Kirshner N.
Purification and properties of bovine phenylethanolamine
N-methyltransferase.
J. Biol. Chem. 245 (1970) 329-34.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.1.28
IUBMB Enzyme Nomenclature: 2.1.1.28
ExPASy - ENZYME nomenclature database: 2.1.1.28
BRENDA, the Enzyme Database: 2.1.1.28
CAS: 9037-68-7 |
|---|
