KEGG   ENZYME: 2.1.1.45Help
Entry
EC 2.1.1.45                 Enzyme                                 
Name thymidylate synthase;
dTMP synthase;
thymidylate synthetase;
methylenetetrahydrofolate:dUMP C-methyltransferase;
TMP synthetase
Class Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
Reaction(IUBMB) 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
[RN:R02101]
Reaction(KEGG) R02101
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Substrate 5,10-methylenetetrahydrofolate [CPD:C00143];
dUMP [CPD:C00365]
Product dihydrofolate [CPD:C00415];
dTMP [CPD:C00364]
Inhibitor 5-Fluorodeoxyuridine monophosphate [CPD:C04242]
Pathway PATH: ec00240  Pyrimidine metabolism
PATH: ec00670  One carbon pool by folate
PATH: ec01100  Metabolic pathways
Orthology KO: K00560  thymidylate synthase
Genes HSA: 7298(TYMS)
PTR: 740018(TYMS)
MCC: 697580(TYMS)
MMU: 22171(Tyms)
RNO: 29261(Tyms)
CFA: 476100 607417
BTA: 507631(TYMS)
ECB: 100060971
MDO: 100013725
OAA: 100077077
GGA: 421060(TYMS)
TGU: 100222097
XLA: 100125228(tyms)
XTR: 780313(tyms)
DRE: 81540(tyms)
BFO: BRAFLDRAFT_77468
CIN: 100182815
SPU: 592043 593137
DME: Dmel_CG3181(Ts)
DPO: Dpse_GA16493
DAN: Dana_GF14907
DER: Dere_GG24473
DPE: Dper_GL26706
DSE: Dsec_GM18183
DSI: Dsim_GD22790
DYA: Dyak_GE14974
DGR: Dgri_GH10649
DMO: Dmoj_GI10845
AGA: AgaP_AGAP010457
AAG: AaeL_AAEL013305
CQU: CpipJ_CPIJ011359
AME: 551983
NVI: 100119314 100122819
TCA: 659164
API: 100165507(Acypi006453)
ISC: IscW_ISCW000960 IscW_ISCW024938
CEL: Y110A7A.4
CBR: CBG20269
BMY: Bm1_33465
NVE: NEMVE_v1g227987
HMG: 100209034
TAD: TRIADDRAFT_18453
ATH: AT2G16370(THY-1)
OSA: 4350527(Os11g0484400)
OLU: OSTLU_49676
CME: CMS462C
SCE: YOR074C(CDC21)
AGO: AGOS_ADR219C
KLA: KLLA0A07843g
LTH: KLTH0F17864g
DHA: DEHA0C06853g
PIC: PICST_37780(TMP1)
PPA: PAS_chr3_0996
VPO: Kpol_1018p80
LEL: LELG_00630
ZRO: ZYRO0A11704g
CAL: CaO19.11033(CDC21)
CTP: CTRG_01661
CDU: CD36_19690
CGR: CAGL0K05467g
YLI: YALI0C10901g
SPO: SPAC15E1.04
NCR: NCU10053
PAN: PODANSg1170
FGR: FG01063.1
ANI: AN7028.2
AFM: AFUA_4G04270
AOR: AO090206000066
ANG: An14g00570
AFV: AFLA_114900
PCS: Pc13g06460
NFI: NFIA_029120
CIM: CIMG_08646
URE: UREG_02640
SSL: SS1G_08456
BFU: BC1G_03147
CNE: CNJ01230
CNB: CNBJ2230
LBC: LACBIDRAFT_192231
MPR: MPER_04156
ECU: ECU01_0180 ECU08_0090
PFA: PFD0805w
PYO: PY04370
TAN: TA08775
TPV: TP04_0504
CPV: cgd4_4460
CHO: Chro.40506
TET: TTHERM_00312120
TBR: Tb927.7.5480
TCR: 509153.90 510303.320
LMA: LmjF06.0860
TVA: TVAG_343240
ECO: b2827(thyA)
ECJ: JW2795(thyA)
ECD: ECDH10B_2997(thyA)
EBW: BWG_2562(thyA)
ECE: Z4144(thyA)
ECS: ECs3684(thyA)
ECF: ECH74115_4093(thyA)
ETW: ECSP_3779(thyA)
ECG: E2348C_3096(thyA)
ECC: c3422(thyA)
ECI: UTI89_C3229(thyA)
ECP: ECP_2840(thyA)
ECV: APECO1_3678(thyA)
ECW: EcE24377A_3147(thyA)
ECX: EcHS_A2973(thyA)
ECM: EcSMS35_2974(thyA)
ECY: ECSE_3084(thyA)
ECL: EcolC_0888(thyA)
ECK: EC55989_3103(thyA)
ECQ: ECED1_3283(thyA)
ECR: ECIAI1_2935(thyA)
ECT: ECIAI39_3246(thyA)
ECZ: ECS88_3122(thyA)
EUM: ECUMN_3154(thyA)
ELF: LF82_2267(thyA)
EBL: B21_02636(thyA)
EBD: ECBD_0898
EBR: ECB_02675(thyA)
EOH: ECO103_3386(thyA)
EOI: ECO111_3555(thyA)
EOJ: ECO26_3899(thyA)
EFE: EFER_2760(thyA)
STY: STY3142(thyA)
STT: t2910(thyA)
SPT: SPA2866(thyA)
SEK: SSPA2669(thyA)
SPQ: SPAB_03733(thyA)
SEI: SPC_3059(thyA)
SEC: SC2940(thyA)
SEH: SeHA_C3214(thyA) SeHA_C4706(thyA)
SEE: SNSL254_A3228(thyA)
SEW: SeSA_A3165(thyA)
SEA: SeAg_B3148(thyA)
SED: SeD_A3328(thyA)
SEG: SG2909(thyA)
SET: SEN2843(thyA)
SES: SARI_04659(thyA)
STM: STM3001(thyA)
YPE: YPO0783(thyA)
YPK: y3171(thyA)
YPM: YP_2875(thyA)
YPA: YPA_0485(thyA)
YPN: YPN_2988(thyA)
YPG: YpAngola_A3238(thyA)
YPP: YPDSF_1702(thyA)
YPS: YPTB3033(thyA)
YPI: YpsIP31758_0984(thyA)
YPY: YPK_1036(thyA)
YPB: YPTS_3155(thyA)
YEN: YE3317(thyA)
SFL: SF2837(thyA)
SFX: S3035(thyA)
SFV: SFV_2905(thyA)
SSN: SSON_2984(thyA)
SBO: SBO_2719(thyA)
SBC: SbBS512_E3035(thyA)
SDY: SDY_3044(thyA)
ECA: ECA0988(thyA)
PCT: PC1_0907
PWA: Pecwa_3396
ETA: ETA_27590(thyA)
PLU: plu0623(thyA)
PAY: PAU_00582(thyA)
BUC: BU440(thyA)
BAS: BUsg425(thyA)
BAB: bbp386(thyA)
BAP: BUAP5A_433(thyA)
BAU: BUAPTUC7_434(thyA)
WBR: WGLp320(thyA)
SGL: SG1977(thyA)
ENT: Ent638_3269(thyA)
ESA: ESA_00482(thyA)
CTU: Ctu_33760(thyA)
KPN: KPN_03236(thyA)
KPE: KPK_0879(thyA)
KPU: KP1_4505(thyA)
CKO: CKO_04194(thyA)
SPE: Spro_0319 Spro_3821(thyA)
PMR: PMI2318(thyA)
EIC: NT01EI_0801
ETR: ETAE_0703(thyA)
HDE: HDEF_1917(thyA)
DDA: Dd703_3014
DDC: Dd586_0900
DZE: Dd1591_3195
HIN: HI0905(thyA)
HIT: NTHI1072(thyA)
HIP: CGSHiEE_07490(thyA)
HIQ: CGSHiGG_08085(thyA)
HDU: HD1005(thyA)
HAP: HAPS_1458(thyA)
HSO: HS_1619(thyA)
HSM: HSM_0391(thyA)
PMU: PM0079(thyA)
MSU: MS0405(thyA)
APL: APL_0115(thyA)
APJ: APJL_0116(thyA)
APA: APP7_0115(thyA)
ASU: Asuc_0725(thyA)
AAP: NT05HA_0084
AAT: D11S_2103
XFA: XF2332(thyA)
XFT: PD1364(thyA)
XFM: Xfasm12_1504(thyA)
XFN: XfasM23_1449(thyA)
XCC: XCC0787(thyA)
XCB: XC_3444(thyA)
XCA: xccb100_3564(thyA)
XCV: XCV0895(thyA)
XAC: XAC0842(thyA)
XOO: XOO3752(thyA)
XOM: XOO_3543(thyA)
XOP: PXO_04649(thyA)
SML: Smlt0813(thyA)
SMT: Smal_0662(thyA)
VCH: VC0675(thyA)
VCO: VC0395_A0207(thyA)
VCM: VCM66_0633(thyA)
VCJ: VCD_003646
VVU: VV1_0516(thyA)
VVY: VV0679(thyA)
VPA: VP0524(thyA)
VHA: VIBHAR_00971(thyA)
VSP: VS_0527(thyA)
VEX: VEA_004427
VFI: VF_0460(thyA)
VFM: VFMJ11_0459(thyA)
VSA: VSAL_I0573(thyA)
PPR: PBPRA0581(thyA)
PAE: PA0342(thyA)
PAU: PA14_04480(thyA)
PAP: PSPA7_0436(thyA)
PAG: PLES_03391(thyA)
PPU: PP_5141(thyA)
PPF: Pput_5043 Pput_5048
PPG: PputGB1_5194(thyA)
PPW: PputW619_0324(thyA)
PST: PSPTO_5282(thyA)
PSB: Psyr_4840(thyA)
PSP: PSPPH_4623 PSPPH_4872(thyA)
PFL: PFL_5895(thyA)
PFO: Pfl01_5373(thyA)
PFS: PFLU5815(thyA)
PEN: PSEEN5234(thyA)
PMY: Pmen_4213(thyA)
PSA: PST_0414(thyA)
CJA: CJA_0468(thyA)
AVN: Avin_48170(thyA)
PAR: Psyc_2011(thyA)
PCR: Pcryo_2314(thyA)
PRW: PsycPRwf_2331(thyA)
ACI: ACIAD0515(thyA)
ACB: A1S_0458(thyA)
ABM: ABSDF3052(thyA) ABSDF3326
ABY: ABAYE3314(thyA)
ABC: ACICU_00468(thyA)
ABN: AB57_0541(thyA)
ABB: ABBFA_003076(thyA)
SON: SO_1335(thyA)
SDN: Sden_2779(thyA)
SFR: Sfri_2942(thyA)
SAZ: Sama_0867(thyA)
SBL: Sbal_1188(thyA)
SBM: Shew185_1232(thyA)
SBN: Sbal195_1265(thyA)
SBP: Sbal223_3125(thyA)
SLO: Shew_1041(thyA)
SPC: Sputcn32_1146(thyA)
SSE: Ssed_1135(thyA)
SPL: Spea_1024(thyA)
SHE: Shewmr4_2861(thyA)
SHM: Shewmr7_2943(thyA)
SHN: Shewana3_3039(thyA)
SHW: Sputw3181_3018(thyA)
SHL: Shal_1070(thyA)
SWD: Swoo_1230(thyA)
SWP: swp_3793(thyA)
ILO: IL0507(thyA)
CPS: CPS_3621(thyA)
PHA: PSHAa0749(thyA)
PAT: Patl_3837(thyA)
SDE: Sde_0350(thyA)
MAQ: Maqu_2432(thyA)
AMC: MADE_03706(thyA)
PIN: Ping_0506(thyA)
TTU: TERTU_0365(thyA)
CBU: CBU_1547(thyA)
CBS: COXBURSA331_A1731(thyA)
CBD: CBUD_0442(thyA)
CBG: CbuG_0464(thyA)
CBC: CbuK_1773(thyA)
LPN: lpg2868(thyA)
LPF: lpl2781(thyA)
LPP: lpp2927(thyA)
LPC: LPC_3154(thyA)
MCA: MCA2728(thyA)
FTU: FTT_1229(thyA)
FTF: FTF1229(thyA)
FTW: FTW_0717(thyA)
FTL: FTL_0715(thyA)
FTH: FTH_0717(thyA)
FTA: FTA_0755(thyA)
FTM: FTM_0714(thyA)
FTN: FTN_1248(thyA)
FPH: Fphi_1432(thyA)
TCX: Tcr_0572
NOC: Noc_0234
AEH: Mlg_0371
HHA: Hhal_2047
TGR: Tgr7_2747
HNA: Hneap_0901
HCH: HCH_05857(thiA)
CSA: Csal_2572
ABO: ABO_2344(thyA)
MMW: Mmwyl1_3742(thyA)
AHA: AHA_0675(thyA)
ASA: ASA_0676(thyA)
TAU: Tola_2961
DNO: DNO_0569(thyA)
BCI: BCI_0544(thyA)
RMA: Rmag_0616(thyA)
VOK: COSY_0568(thyA)
KKO: Kkor_2414
NMA: NMA1963(thyA)
NME: NMB1709(thyA)
NMC: NMC1624(thyA)
NMN: NMCC_1620(thyA)
NMI: NMO_1523(thyA)
NGO: NGO1357(thyA)
NGK: NGK_1590(thyA)
CVI: CV_1027(thyA)
LHK: LHK_00786(tysY)
RSO: RSc0947(thyA)
RPI: Rpic_0818(thyA)
RPF: Rpic12D_0889
REU: Reut_A0915(thyA)
REH: H16_A2703(thyA)
RME: Rmet_2568(thyA)
CTI: RALTA_A2194(thyA)
BMA: BMA0382(thyA)
BMV: BMASAVP1_A2523(thyA)
BML: BMA10229_A0897(thyA)
BMN: BMA10247_0251(thyA)
BPS: BPSL2473(thyA) BPSS1106
BPM: BURPS1710b_2946(thyA) BURPS1710b_A0064
BPL: BURPS1106A_2895(thyA) BURPS1106A_A1475
BPD: BURPS668_2833(thyA) BURPS668_A1563
BPR: GBP346_A3013(thyA_1)
BTE: BTH_I1680(thyA) BTH_II1303
BVI: Bcep1808_1005(thyA)
BUR: Bcep18194_A4199(thyA)
BCN: Bcen_0606(thyA)
BCH: Bcen2424_1085(thyA)
BCM: Bcenmc03_1044(thyA)
BCJ: BCAL2912(thyA)
BAM: Bamb_0961(thyA)
BAC: BamMC406_0965(thyA)
BMU: Bmul_2218(thyA)
BMJ: BMULJ_01021(thyA)
BXE: Bxe_A0214 Bxe_A1031(thyA)
BPH: Bphy_0788(thyA)
BPY: Bphyt_2954(thyA)
BGL: bglu_1g09170 bglu_2g17520
PNU: Pnuc_0381(thyA)
PNE: Pnec_0387(thyA)
BPE: BP3154(thyA)
BPA: BPP0787(thyA)
BBR: BB0872(thyA)
BPT: Bpet4034(thyA)
BAV: BAV0507(thyA)
RFR: Rfer_1063 Rfer_2986(thyA)
POL: Bpro_1823(thyA)
PNA: Pnap_2772(thyA)
AAV: Aave_1450(thyA)
AJS: Ajs_1197(thyA)
VEI: Veis_3172
DAC: Daci_4970
DIA: Dtpsy_1116
VAP: Vapar_1664
CTT: CtCNB1_3258
MPT: Mpe_A2051(thyA) Mpe_B0137
HAR: HEAR1056(thyA)
MMS: mma_1193(thyA)
LCH: Lcho_1260
NEU: NE0568(thyA)
NET: Neut_1021(thyA)
NMU: Nmul_A1962(thyA)
EBA: ebA4415(thyA)
AZO: azo3197(thyA)
DAR: Daro_0593(thyA)
TMZ: Tmz1t_1592
TBD: Tbd_2040
MFA: Mfla_0906(thyA) Mfla_1050(thyA)
MMB: Mmol_1531
MEI: Msip34_0877
APP: CAP2UW1_0561
BBA: Bd3230(thyA)
DOL: Dole_1745
DAL: Dalk_4147
MXA: MXAN_5942(thyA)
HOH: Hoch_5412
MLO: mll1467(thyA)
MES: Meso_1751
PLA: Plav_2448
SME: SMc01444(thyA)
SMD: Smed_2021(thyA)
ATU: Atu2047(thyA)
ATC: AGR_C_3709
ARA: Arad_2934(thyA)
AVI: Avi_2822(thyA)
RET: RHE_CH02799(thyA)
REC: RHECIAT_CH0002942(thyA)
RLE: RL3256(thyA)
RLT: Rleg2_2543(thyA)
RLG: Rleg_2802
RHI: NGR_c20540(thyA)
LAS: CLIBASIA_04275(thyA)
BME: BMEI0608(thyA)
BMF: BAB1_1418(thyA)
BMB: BruAb1_1394(thyA)
BMC: BAbS19_I13250(thyA)
BMS: BR1399(thyA)
BMT: BSUIS_A1450(thyA)
BOV: BOV_1355(thyA)
BCS: BCAN_A1431(thyA)
BMR: BMI_I1410(thyA)
OAN: Oant_1792(thyA)
BJA: bll6512(thyA)
BRA: BRADO5578(thyA)
BBT: BBta_6100(thyA)
RPA: RPA3493(thyA)
RPB: RPB_2036(thyA)
RPC: RPC_3266(thyA)
RPD: RPD_3354(thyA)
RPE: RPE_2149 RPE_2150
RPT: Rpal_4007(thyA)
NWI: Nwi_2351(thyA)
NHA: Nham_2730(thyA)
OCA: OCAR_5276(thyA)
BHE: BH10980(thyA)
BQU: BQ08630(thyA)
BBK: BARBAKC583_0926(thyA)
BTR: Btr_1568(thyA)
BGR: Bgr_13730(thyA)
XAU: Xaut_3514
MEX: Mext_2660
MEA: Mex_1p2853(thyA)
MDI: METDI3419(thyA)
MRD: Mrad2831_4525
MET: M446_1091
MPO: Mpop_2782
MCH: Mchl_2887
MNO: Mnod_0699
BID: Bind_1545
MSL: Msil_0600
CCR: CC_2124(thyA)
CCS: CCNA_02208
CAK: Caul_2001 Caul_3385(thyA)
PZU: PHZ_c0819(thyA)
SIT: TM1040_1729(thyA)
RSP: RSP_0390
RSH: Rsph17029_2044
RSQ: Rsph17025_0846
RSK: RSKD131_1719
RDE: RD1_1874(thyA)
MMR: Mmar10_2027
HNE: HNE_0459(thyA)
HBA: Hbal_0454
ZMO: ZMO1755
ZMN: Za10_1469
NAR: Saro_1977
SAL: Sala_1332
SWI: Swit_3787
ELI: ELI_05150
RCE: RC1_2002(thyA)
MAG: amb1327
BSU: BSU17680(thyA) BSU21820(thyB)
BHA: BH3451(thyA)
BAN: BA2236(thyA)
BAR: GBAA2236(thyA)
BAA: BA_2740
BAT: BAS2082(thyA)
BAH: BAMEG_2358(thyA)
BAI: BAA_2300(thyA)
BCE: BC2191(thyA)
BCA: BCE_2266(thyA)
BCZ: BCZK2020(thyA)
BCR: BCAH187_A2348(thyA)
BCB: BCB4264_A2219(thyA)
BCU: BCAH820_2263(thyA)
BCG: BCG9842_B3105(thyA)
BCQ: BCQ_2174(thyA)
BCX: BCA_2321(thyA)
BCY: Bcer98_1639(thyA)
BTK: BT9727_2020(thyA)
BTL: BALH_2000(thyA)
BWE: BcerKBAB4_2061(thyA)
BLI: BL02642(thyA)
BLD: BLi02029(thyA)
BCL: ABC2955(thyA)
BAY: RBAM_005690 RBAM_019970(thyA)
BPU: BPUM_1916(thyA)
OIH: OB1740(thyA)
GKA: GK1776(thyA)
GTN: GTNG_1671(thyA)
GWC: GWCH70_1581
GYM: GYMC10_2405
GYC: GYMC61_2589
AFL: Aflv_1455(thyA)
SAU: SA1260(thyA)
SAV: SAV1427(thyA)
SAW: SAHV_1415(thyA)
SAM: MW1317(thyA)
SAR: SAR1440(thyA)
SAS: SAS1370(thyA)
SAC: SACOL1462(thyA)
SAB: SAB1282c(thyA)
SAA: SAUSA300_1320(thyA)
SAX: USA300HOU_1364(thyA)
SAO: SAOUHSC_01435(thyA)
SAJ: SaurJH9_1487(thyA)
SAH: SaurJH1_1516(thyA)
SAE: NWMN_1338(thyA)
SAD: SAAV_1410(thyA)
SEP: SE1120(thyA)
SER: SERP1003(thyA) SERP1582(thyA)
SHA: SH1479(thyA)
SSP: SSP1312(thyA)
SCA: Sca_1071(thyA)
LMO: lmo1874(thyA)
LMF: LMOf2365_1904(thyA)
LMH: LMHCC_0682(thyA)
LMC: Lm4b_01891
LIN: lin1988(thyA)
LWE: lwe1894(thyA)
LSP: Bsph_2692(thyA)
ESI: Exig_1741
EAT: EAT1b_0141
MCL: MCCL_1078(thyA)
BBE: BBR47_43880(tysY)
PJD: Pjdr2_2655
LLA: L182559(thyA)
LLK: LLKF_1662(thyA)
LLC: LACR_1631(thyA)
LLM: llmg_0964(thyA)
SPY: SPy_0882(thyA)
SPZ: M5005_Spy_0688(thyA)
SPM: spyM18_0943(thyA)
SPG: SpyM3_0601(thyA)
SPS: SPs1252(thyA)
SPH: MGAS10270_Spy0746(thyA)
SPI: MGAS10750_Spy0780(thyA)
SPJ: MGAS2096_Spy0760(thyA)
SPK: MGAS9429_Spy0744(thyA)
SPF: SpyM51120(thyA)
SPA: M6_Spy0705(thyA)
SPB: M28_Spy0668(thyA)
SOZ: Spy49_0696(thyA)
SPN: SP_0669(thyA)
SPD: SPD_0581(thyA)
SPR: spr0585(thyA)
SPW: SPCG_0625(thyA)
SPX: SPG_0610(thyA)
SNE: SPN23F_06050(thyA)
SPV: SPH_0764(thyA)
SNM: SP70585_0728(thyA)
SJJ: SPJ_0620(thyA)
SPP: SPP_0690(thyA)
SNT: SPT_0693(thyA)
SAG: SAG1315(thyA)
SAN: gbs1385(thyA)
SAK: SAK_1346(thyA)
SMU: SMU.944(thyA)
STC: str0578(thyA)
STL: stu0578(thyA)
STE: STER_0622(thyA)
SSA: SSA_1091(thyA)
SSU: SSU05_0834(thyA)
SSV: SSU98_0834(thyA)
SSB: SSUBM407_1057(thyA)
SSI: SSU0778(thyA)
SSS: SSUSC84_0741(thyA)
SGO: SGO_1143(thyA)
SEQ: SZO_08890
SEZ: Sez_1078(thyA)
SEU: SEQ_1110
SUB: SUB0771(thyA)
SDS: SDEG_0845(thyA)
LPL: lp_1870(thyA)
LPJ: JDM1_1572(thyA)
LJO: LJ1471(thyA)
LJF: FI9785_796(thyA)
LAC: LBA0901(thyA)
LSA: LSA1001(thyA)
LSL: LSL_0708(thyA)
LDB: Ldb0787(thyA)
LBU: LBUL_0720(thyA)
LBR: LVIS_0784(thyA)
LCA: LSEI_1387(thyA)
LCB: LCABL_16070(thyA)
LGA: LGAS_0830(thyA)
LRE: Lreu_0769(thyA)
LRF: LAR_0739(thyA)
LHE: lhv_0955(thyA)
LFE: LAF_0887(thyA)
LRH: LGG_01397(thyA)
LRL: LC705_01413(thyA)
PPE: PEPE_1070(thyA)
EFA: EF1576(thyA)
OOE: OEOE_0782(thyA)
LME: LEUM_0458(thyA) LEUM_1454
LCI: LCK_01324(thyA)
CAC: CAC3003(thyA)
CTC: CTC02216
CTH: Cthe_1227
CDC: CD196_0055
CDL: CDR20291_0043
CBO: CBO0768
CBA: CLB_0810(thyA)
CBH: CLC_0824(thyA)
CBY: CLM_0918(thyA)
CBL: CLK_0176(thyA)
CBK: CLL_A1349(thyA) CLL_A3448(thyA)
CBB: CLD_3796(thyA)
CBI: CLJ_B0817(thyA)
CBT: CLH_3227(thyA)
CBF: CLI_0854(thyA)
CBE: Cbei_4952(thyA)
CCE: Ccel_1309
STH: STH3117(thyA)
VPR: Vpar_1385
DAE: Dtox_0188
ERE: EUBREC_1248
MGE: MG_227(thyA)
MPN: MPN320(thyA)
MPU: MYPU_5380(thyA)
MPE: MYPE6870(thyA)
MGA: MGA_0699(thyA)
MMO: MMOB0340(thyA)
MSY: MS53_0398(thyA)
POY: PAM293(thyA)
AYW: AYWB_430(thyA)
PML: ATP_00320(thyA)
PAL: PAa_0084(thyA)
ACL: ACL_0691(thyA)
MFL: Mfl419(thyA)
MTU: Rv2764c(thyA)
MTC: MT2834(thyA)
MRA: MRA_2789(thyA)
MTF: TBFG_12777(thyA)
MTB: TBMG_01211(TBMG_01211.1)
MBO: Mb2786c(thyA)
MBB: BCG_2781c(thyA)
MBT: JTY_2775(thyA)
MLE: ML1519(thyA)
MLB: MLBr_01519(thyA)
MPA: MAP2869c(thyA)
MAV: MAV_3652(thyA)
MSM: MSMEG_2670(thyA)
MUL: MUL_2178(thyA)
MVA: Mvan_2380(thyA)
MGI: Mflv_4007(thyA)
MAB: MAB_3091c
MMC: Mmcs_2112(thyA)
MKM: Mkms_2158(thyA)
MJL: Mjls_2099(thyA)
MMI: MMAR_0027(thyA_1) MMAR_1956(thyA)
CGL: NCgl0810(thyA)
CGB: cg0966(thyA)
CGT: cgR_0959(thyA)
CEF: CE0919(thyA)
CDI: DIP0825(thyA)
CJK: jk0441(thyA)
CUR: cur_1520(thyA)
CAR: cauri_0792(thyA)
CKP: ckrop_0461
NFA: nfa50220(thyA)
RHA: RHA1_ro02248(thyA)
RER: RER_44610(thyA)
ROP: ROP_19620(thyA)
GBR: Gbro_2176
LXX: Lxx09930(thyA)
ART: Arth_3018(thyA)
AAU: AAur_2992(thyA)
ACH: Achl_2730 Achl_4491
RSA: RSal33209_0958
KRH: KRH_05690(thyA)
MLU: Mlut_17460
BCV: Bcav_2864
BFA: Bfae_29370
JDE: Jden_1030
KSE: Ksed_09380
XCE: Xcel_2834
PAC: PPA1672(thyA)
NCA: Noca_2311
SRO: Sros_0805 Sros_4922
NML: Namu_2812
KRA: Krad_4439
CAI: Caci_5812
BLO: BL1665(thyA)
BLJ: BLD_1789(thyA)
BLN: Blon_2142(thyA)
BAD: BAD_0388(thyA)
BLA: BLA_0434(thyA)
BLC: Balac_0457(thyA)
BLT: Balat_0457(thyA)
APV: Apar_0632
LIL: LA0789
BHY: BHWA1_00171(thyA)
SUS: Acid_4038
BTH: BT_2047(thyA)
BFR: BF3734(thyA)
BFS: BF3523(thyA)
BVU: BVU_1950(thyA)
PGI: PG2060(thyA)
PGN: PGN_2062(thyA)
PDI: BDI_3749(thyA)
APS: CFPG_510
SRU: SRU_0419(thyA)
RMR: Rmar_0340
CHU: CHU_1289(thyA)
DFE: Dfer_5002
CPI: Cpin_6453
PHE: Phep_1422
GFO: GFO_0288(thyA)
FJO: Fjoh_1471(thyA)
FPS: FP0333(thyA)
FBA: FIC_01771
COC: Coch_1242
RBI: RB2501_03215
BBL: BLBBGE_498(thyA)
BPI: BPLAN_141(thyA)
AAS: Aasi_1410
FSU: Fisuc_2511
FNU: FN0240
LBA: Lebu_0681
STR: Sterm_1609
OTE: Oter_1327
MIN: Minf_0110(thyA)
AMU: Amuc_2032
RBA: RB12614(thyA)
MAR: MAE_42510
CYT: cce_0382
CYP: PCC8801_1245
CYC: PCC7424_0726
CYN: Cyan7425_0815
CYH: Cyan8802_1276
CPC: Cpar_0292
DET: DET0819
DEH: cbdb_A796(thyA)
DEB: DehaBAV1_0738
DEV: DhcVS_723
DRA: DR_2630(thyA)
DDR: Deide_23040(thyA)
MJA: MJ0511(thyA)
MFE: Mefer_0421
MVU: Metvu_1402
MMP: MMP0986(thyA) MMP1379(thyA)
MMQ: MmarC5_0199(thyA)
MMX: MmarC6_1294(thyA)
MMZ: MmarC7_0624(thyA)
MAE: Maeo_1049(thyA)
MVN: Mevan_0689(thyA)
MAC: MA4543(thyA)
MBA: Mbar_A0890(thyA)
MMA: MM_1237(thyA)
MBU: Mbur_1079(thyA)
MTP: Mthe_0710(thyA)
MHU: Mhun_1795
MLA: Mlab_0109
MEM: Memar_0549
MBN: Mboo_0521
MPL: Mpal_0076
MPD: MCP_1209(thyA)
MTH: MTH774(thyA)
MST: Msp_1237(thyA)
MSI: Msm_1734
MKA: MK1370(thyA)
AFU: AF2047
HWA: HQ2456A(thyA)
NPH: NP2924A(thyA)
HLA: Hlac_2166
HMU: Hmuk_3006
RCI: LRC337(thyA)
PAI: PAE1752
PIS: Pisl_1715
PCL: Pcal_0637
PAS: Pars_0748
TNE: Tneu_0735
TPE: Tpen_0948
Taxonomy
Structures PDB: 1AIQ  1AJM  1AN5  1AOB  1AXW  1B02  1BDU  1BID  1BJG  1BKO  
     1BKP  1BO7  1BO8  1BP0  1BP6  1BPJ  1BQ1  1BQ2  1BSF  1BSP  
     1CI7  1DDU  1DNA  1EV5  1EV8  1EVF  1EVG  1F28  1F4B  1F4C  
     1F4D  1F4E  1F4F  1F4G  1FFL  1FWM  1HVY  1HW3  1HW4  1HZW  
     1I00  1J3I  1J3J  1J3K  1JG0  1JMF  1JMG  1JMH  1JMI  1JTQ  
     1JTU  1JU6  1JUJ  1JUT  1KCE  1KZI  1KZJ  1LCA  1LCB  1LCE  
     1NCE  1NJA  1NJB  1NJC  1NJD  1NJE  1QQQ  1QZF  1RTS  1SEJ  
     1SYN  1TDA  1TDB  1TDC  1TDU  1THY  1TIS  1TJS  1TLC  1TLS  
     1TRG  1TSD  1TSL  1TSM  1TSN  1TSV  1TSW  1TSX  1TSY  1TSZ  
     1TVU  1TVV  1TVW  1TYS  1VZA  1VZB  1VZC  1VZD  1VZE  1YPV  
     1ZPR  2A9W  2AAZ  2BBQ  2FTN  2FTO  2FTQ  2G86  2G89  2G8A  
     2G8D  2G8M  2G8O  2G8X  2H2Q  2KCE  2OIP  2RD8  2RDA  2TDD  
     2TDM  2TSC  2TSR  2VET  2VF0  3B5B  3B9H  3BFI  3BGX  3BHL  
     3BHR  3BNZ  3BYX  3BZ0  3C06  3C0A  3CL9  3CLB  3DG8  3DGA  
     3EGY  3EHI  3HBB  3I3R  3IX6  3K2H  3KGB  3KJR  3TMS  4TMS  
Reference
  Authors
  Title

  Journal
 1
Blakley, R.L.
The biosynthesis of thymidylic acid. IV. Further studies on
thymidylate synthase.
J. Biol. Chem. 238 (1963) 2113-2118.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:34155]
Lockshin A, Moran RG, Danenberg PV.
Thymidylate synthetase purified to homogeneity from human leukemic
cells.
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 750-4.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title

  Journal
 3  [PMID:6990200]
Slavik K, Slavikova V.
Purification of thymidylate synthetase from enzyme-poor sources by
affinity chromatography.
Methods. Enzymol. 66 (1980) 709-23.
Reference
  Authors
  Title

  Journal
  Organism
 4  [PMID:13998281]
WAHBA AJ, FRIEDKIN M.
The enzymatic synthesis of thymidylate. I. Early steps in the
purification of thymidylate synthetase of Escherichia coli.
J. Biol. Chem. 237 (1962) 3794-801.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 2.1.1.45
IUBMB Enzyme Nomenclature: 2.1.1.45
ExPASy - ENZYME nomenclature database: 2.1.1.45
BRENDA, the Enzyme Database: 2.1.1.45
CAS: 9031-61-2
DBGET integrated database retrieval system