KEGG   ENZYME: 2.1.1.49Help
Entry
EC 2.1.1.49                 Enzyme                                 

Name
amine N-methyltransferase;
nicotine N-methyltransferase;
tryptamine N-methyltransferase;
arylamine N-methyltransferase;
tryptamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:amine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine [RN:R02808]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
amine [CPD:C00706]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methylated amine [CPD:C02436]
Comment
An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.
History
EC 2.1.1.49 created 1976, modified 1990 (EC 2.1.1.81 created 1989, incorporated 1990)
Pathway
Tryptophan metabolism
Orthology
K00562  
methyltransferase
Genes
HSA: 
11185(INMT)
PTR: 
463912(INMT)
PPS: 
100986665(INMT)
GGO: 
101143120(INMT)
PON: 
100171421(INMT)
MCC: 
694969(INMT)
MCF: 
102139220(INMT)
MMU: 
21743(Inmt)
RNO: 
368066(Inmt)
CGE: 
100773805(Inmt)
HGL: 
TUP: 
BTA: 
527922(INMT)
BOM: 
PHD: 
CHX: 
SSC: 
100512997(INMT)
CFR: 
BACU: 
LVE: 
ECB: 
100055070(INMT)
ACS: 
XLA: 
399013(inmt)
XTR: 
BFO: 
ISC: 
 » show all
Taxonomy
Reference
1  [PMID:3949799]
  Authors
Ansher SS, Jakoby WB.
  Title
Amine N-methyltransferases from rabbit liver.
  Journal
J. Biol. Chem. 261 (1986) 3996-4001.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:3377829]
  Authors
Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB.
  Title
Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases.
  Journal
Biochem. Pharmacol. 37 (1988) 1673-7.
  Organism
Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
51377-47-0 111694-10-1

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