KEGG   ENZYME: 2.1.1.5Help
Entry
EC 2.1.1.5                  Enzyme                                 
Name
betaine---homocysteine S-methyltransferase;
betaine-homocysteine methyltransferase;
betaine-homocysteine transmethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
trimethylammonioacetate:L-homocysteine S-methyltransferase
Reaction(IUBMB)
betaine + L-homocysteine = dimethylglycine + L-methionine [RN:R02821]
Reaction(KEGG)
Substrate
betaine [CPD:C00719];
L-homocysteine [CPD:C00155]
Product
dimethylglycine [CPD:C01026];
L-methionine [CPD:C00073]
Pathway
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Metabolic pathways
Orthology
K00544  
betaine-homocysteine S-methyltransferase
Genes
HSA: 
635(BHMT)
PTR: 
461786(BHMT)
PPS: 
100985336(BHMT)
GGO: 
101138811(BHMT)
PON: 
100174207(BHMT)
MCC: 
714363(BHMT)
MMU: 
12116(Bhmt)
RNO: 
81508(Bhmt)
CFA: 
479171(BHMT)
AML: 
FCA: 
101085179(BHMT)
BTA: 
497025(BHMT)
SSC: 
100739497 397371(BHMT)
ECB: 
100073265
MDO: 
100032615
SHR: 
100927569(BHMT)
OAA: 
100088080
GGA: 
416371(BHMT)
MGP: 
100541641
TGU: 
100221623(BHMT)
ACS: 
100558455
XLA: 
495275(bhmt)
XTR: 
496651(bhmt)
DRE: 
322228(bhmt)
TRU: 
101061373 101062063
OLA: 
101157623
BFO: 
BRAFLDRAFT_78594
CIN: 
100182838
SPU: 
575553
NVE: 
NEMVE_v1g236455
HMG: 
100206048
TAD: 
TRIADDRAFT_63716
CSA: 
Csal_0065
PUB: 
SAR11_1173(bhmT)
MLO: 
mlr1281
 » show all
Taxonomy
Reference
1  [PMID:14456704]
  Authors
KLEE WA, RICHARDS HH, CANTONI GL.
  Title
The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver.
  Journal
Biochim. Biophys. Acta. 54 (1961) 157-64.
  Organism
Equus caballus [GN:ecb], Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-78-1
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