KEGG   ENZYME: 2.1.1.5Help
Entry
EC 2.1.1.5                  Enzyme                                 

Name
betaine---homocysteine S-methyltransferase;
betaine-homocysteine methyltransferase;
betaine-homocysteine transmethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
trimethylammonioacetate:L-homocysteine S-methyltransferase
Reaction(IUBMB)
betaine + L-homocysteine = dimethylglycine + L-methionine [RN:R02821]
Reaction(KEGG)
Substrate
betaine [CPD:C00719];
L-homocysteine [CPD:C00155]
Product
dimethylglycine [CPD:C01026];
L-methionine [CPD:C00073]
History
EC 2.1.1.5 created 1961
Pathway
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Metabolic pathways
Orthology
K00544  
betaine-homocysteine S-methyltransferase
Genes
HSA: 
635(BHMT)
PTR: 
461786(BHMT)
PPS: 
100985336(BHMT)
GGO: 
101138811(BHMT)
PON: 
100174207(BHMT)
MCC: 
714363(BHMT)
MCF: 
102117049(BHMT)
MMU: 
12116(Bhmt)
RNO: 
81508(Bhmt)
CGE: 
100754488(Bhmt)
HGL: 
101723121(Bhmt)
TUP: 
102489167(BHMT)
CFA: 
479171(BHMT)
AML: 
FCA: 
101085179(BHMT)
PTG: 
102955687(BHMT)
BTA: 
497025(BHMT)
BOM: 
102286920(BHMT)
PHD: 
102328254(BHMT)
CHX: 
102175297(BHMT)
OAS: 
101113853(BHMT)
SSC: 
CFR: 
102523171(BHMT)
BACU: 
103000437(BHMT)
LVE: 
103081575(BHMT)
ECB: 
100073265(BHMT)
MYB: 
102252728(BHMT)
MYD: 
102775016(BHMT)
PALE: 
102887754(BHMT)
MDO: 
100032615(BHMT)
SHR: 
100927569(BHMT)
OAA: 
100088080(BHMT)
GGA: 
416371(BHMT)
MGP: 
TGU: 
100221623(BHMT)
FAB: 
101813460(BHMT)
PHI: 
102112767(BHMT)
APLA: 
101802407(BHMT)
FPG: 
101910450(BHMT)
FCH: 
102048321(BHMT)
CLV: 
102097034(BHMT)
ASN: 
102378363(BHMT)
AMJ: 
102561209(BHMT)
PSS: 
102445649(BHMT)
CMY: 
102947612(BHMT)
ACS: 
PBI: 
103049200(BHMT)
XLA: 
495275(bhmt)
XTR: 
496651(bhmt)
DRE: 
322228(bhmt)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102351553(BHMT)
CMK: 
103177766(bhmt)
BFO: 
CIN: 
SPU: 
ISC: 
NVE: 
HMG: 
TAD: 
AQU: 
FRT: 
SPIU: 
CSA: 
PUB: 
APC: 
APM: 
HHD: 
VIR: 
BSE: 
FSI: 
 » show all
Taxonomy
Reference
1  [PMID:14456704]
  Authors
KLEE WA, RICHARDS HH, CANTONI GL.
  Title
The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver.
  Journal
Biochim. Biophys. Acta. 54 (1961) 157-64.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-78-1

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