| Entry |
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| Name |
catechol O-methyltransferase;
COMT I ;
COMT II;
S-COMT (soluble form of catechol-O-methyltransferase);
MB-COMT (membrane-bound form of catechol-O-methyltransferase);
catechol methyltransferase;
catecholamine O-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
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| Sysname |
S-adenosyl-L-methionine:catechol O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol [RN: R07330]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
guaiacol [CPD: C01502]
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| Comment |
The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.
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| Pathway |
| Steroid hormone biosynthesis | | Tyrosine metabolism | | Betalain biosynthesis | | Metabolic pathways |
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| Orthology |
| catechol O-methyltransferase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | SMO: | | PPP: | | OLU: | | OTA: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | CIM: | | CPW: | | PBL: | | PNO: | | PTE: | | ZTR: | | SPO: | | PTI: | | TPS: | | PIF: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTG: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MBO: | | MBB: | | MBT: | | MBM: | | MBK: | | MAF: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MJD: | | MMI: | | MRH: | | MMM: | | MLI: | |
» show all
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| Reference |
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| Authors |
AXELROD J, TOMCHICK R. |
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| Title |
Enzymatic O-methylation of epinephrine and other catechols. |
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| Journal |
J. Biol. Chem. 233 (1958) 702-5. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
|
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| Authors |
Gulliver PA, Tipton KF. |
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| Title |
The purification and properties of pig brain catechol-o-methyltransferase. |
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| Journal |
J. Neurochem. 32 (1979) 1525-9. |
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| Organism |
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| Reference |
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| Authors |
Huh MM, Friedhoff AJ. |
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| Title |
Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization. |
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| Journal |
J. Biol. Chem. 254 (1979) 299-308. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9012-25-3 |
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