KEGG   ENZYME: 2.1.1.6Help
Entry
EC 2.1.1.6                  Enzyme                                 
Name catechol O-methyltransferase;
COMT I ;
COMT II;
S-COMT (soluble form of catechol-O-methyltransferase);
MB-COMT (membrane-bound form of catechol-O-methyltransferase);
catechol methyltransferase;
catecholamine O-methyltransferase
Class Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname S-adenosyl-L-methionine:catechol O-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a
guaiacol [RN:R07330]
Reaction(KEGG) R07330 > R00827 R02534 R02920 R03304 R04301 R04762 R04764 R04881
R04887
Show
Substrate S-adenosyl-L-methionine [CPD:C00019];
catechol [CPD:C00090]
Product S-adenosyl-L-homocysteine [CPD:C00021];
guaiacol [CPD:C01502]
Comment The mammalian enzyme acts more rapidly on catecholamines such as
adrenaline or noradrenaline than on catechols.
Pathway PATH: ec00140  Steroid hormone biosynthesis
PATH: ec00350  Tyrosine metabolism
PATH: ec00965  Betalain biosynthesis
PATH: ec01100  Metabolic pathways
Orthology KO: K00545  catechol O-methyltransferase
Genes HSA: 1312(COMT)
PTR: 458655(COMT)
MCC: 712548
MMU: 12846(Comt1)
RNO: 24267(Comt)
CFA: 445450(COMT)
BTA: 618278(COMT)
SSC: 100155530
ECB: 100033869(COMT)
MDO: 100031097
GGA: 416783(COMT)
TGU: 100223814
XLA: 379402(MGC53924)
XTR: 549111
DRE: 565370
BFO: BRAFLDRAFT_58314
CIN: 100177407 100183642 100184113
SPU: 581002
PPP: PHYPADRAFT_229935
OLU: OSTLU_8287
DHA: DEHA0C03916g
PIC: PICST_36800(COM1)
LEL: LELG_05152
CAL: CaO19.7140(CMT1)
CTP: CTRG_04975
CDU: CD36_73940(CMT1)
YLI: YALI0B03124g
SPO: SPBPB21E7.04c
NCR: NCU07919
PAN: PODANSg7751
MGR: MGG_00015
FGR: FG00244.1
ANI: AN6402.2
AFM: AFUA_2G15085 AFUA_5G06990
AOR: AO090701000285
ANG: An17g00200
AFV: AFLA_057420
NFI: NFIA_058000 NFIA_080270
CIM: CIMG_06092
SSL: SS1G_08337
BFU: BC1G_03058
PTI: PHATRDRAFT_9546
TPS: THAPSDRAFT_261719
MTU: Rv1703c
MTC: MT1743
MRA: MRA_1712
MTF: TBFG_11718
MTB: TBMG_02293(TBMG_02293.1)
MBO: Mb1729c
MBB: BCG_1741c
MBT: JTY_1716
MPA: MAP1409c
MAV: MAV_3069
MUL: MUL_1691
MVA: Mvan_3280
MGI: Mflv_3499
MAB: MAB_1318c
MMI: MMAR_2507
Taxonomy
Structures PDB: 1H1D  1JR4  1VID  2CL5  2ZLB  2ZTH  2ZVJ  3BWM  3BWY  3HVH  
     3HVI  3HVJ  3HVK  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13575440]
AXELROD J, TOMCHICK R.
Enzymatic O-methylation of epinephrine and other catechols.
J. Biol. Chem. 233 (1958) 702-5.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:438821]
Gulliver PA, Tipton KF.
The purification and properties of pig brain
catechol-o-methyltransferase.
J. Neurochem. 32 (1979) 1525-9.
Sus scofa [GN:ssc]
Reference
  Authors
  Title


  Journal
  Organism
 3  [PMID:762061]
Huh MM, Friedhoff AJ.
Multiple molecular forms of catechol-O-methyltransferase. Evidence
for two distinct forms, and their purification and physical
characterization.
J. Biol. Chem. 254 (1979) 299-308.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 2.1.1.6
IUBMB Enzyme Nomenclature: 2.1.1.6
ExPASy - ENZYME nomenclature database: 2.1.1.6
BRENDA, the Enzyme Database: 2.1.1.6
CAS: 9012-25-3
DBGET integrated database retrieval system