KEGG   ENZYME: 2.1.1.6Help
Entry
EC 2.1.1.6                  Enzyme                                 

Name
catechol O-methyltransferase;
COMT I ;
COMT II;
S-COMT (soluble form of catechol-O-methyltransferase);
MB-COMT (membrane-bound form of catechol-O-methyltransferase);
catechol methyltransferase;
catecholamine O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:catechol O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol [RN:R07330]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
catechol [CPD:C00090]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
guaiacol [CPD:C01502]
Comment
The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.
Pathway
Steroid hormone biosynthesis
Tyrosine metabolism
Betalain biosynthesis
Metabolic pathways
Orthology
K00545  
catechol O-methyltransferase
Genes
HSA: 
1312(COMT)
PTR: 
458655(COMT)
PPS: 
100982622(COMT)
GGO: 
101134139(COMT)
PON: 
100455627(COMT)
MCC: 
712548(COMT)
MCF: 
102114823(COMT)
MMU: 
12846(Comt)
RNO: 
24267(Comt)
CGE: 
HGL: 
101717730(Comt)
TUP: 
102485737(COMT)
CFA: 
445450(COMT)
FCA: 
101097022(COMT)
BTA: 
618278(COMT)
BOM: 
102271180(COMT)
PHD: 
102320187(COMT)
CHX: 
SSC: 
100155530(COMT)
CFR: 
102522928(COMT)
ECB: 
100146509(COMT)
MYB: 
102256228(COMT)
MDO: 
SHR: 
100934159(COMT)
OAA: 
GGA: 
416783(COMT)
MGP: 
TGU: 
100223814(COMT)
FAB: 
101818536(COMT)
PHI: 
102099819(COMT)
APLA: 
101805407(COMT)
FPG: 
101916407(COMT)
FCH: 
102046620(COMT)
CLV: 
102088102(COMT)
ASN: 
102371384(COMT)
PSS: 
102459109(COMT)
XLA: 
379402(MGC53924)
XTR: 
DRE: 
561372(comta) 565370(comtb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
SMO: 
PPP: 
OLU: 
OTA: 
MIS: 
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.7140(CMT1) CaO19_7140(CaJ7_0501)
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_526114(AO090701000285)
ANG: 
ANI_1_376154(An17g00200)
AFV: 
ACT: 
CIM: 
CPW: 
PBL: 
PNO: 
PTE: 
ZTR: 
SPO: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
MTU: 
MTV: 
MTC: 
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MBO: 
MBB: 
MBT: 
MBM: 
MBK: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MPA: 
MAO: 
MAV: 
MIT: 
MIR: 
MIA: 
MID: 
MYO: 
MSA: 
MUL: 
MVA: 
MGI: 
MSP: 
MAB: 
MABB: 
MJD: 
MMI: 
MRH: 
MMM: 
MLI: 
MKN: 
 » show all
Taxonomy
Reference
1  [PMID:13575440]
  Authors
AXELROD J, TOMCHICK R.
  Title
Enzymatic O-methylation of epinephrine and other catechols.
  Journal
J. Biol. Chem. 233 (1958) 702-5.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:438821]
  Authors
Gulliver PA, Tipton KF.
  Title
The purification and properties of pig brain catechol-o-methyltransferase.
  Journal
J. Neurochem. 32 (1979) 1525-9.
  Organism
Sus scofa [GN:ssc]
Reference
3  [PMID:762061]
  Authors
Huh MM, Friedhoff AJ.
  Title
Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization.
  Journal
J. Biol. Chem. 254 (1979) 299-308.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-25-3

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