| Entry |
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| Name |
thiopurine S-methyltransferase;
mercaptopurine methyltransferase;
thiopurine methyltransferase;
6-thiopurine transmethylase;
TPMT
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:thiopurine S-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether [RN: R03701]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
thiopurine [CPD: C01756]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
thiopurine S-methylether [CPD: C16614]
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| Comment |
Also acts, more slowly, on thiopyrimidines and aromatic thiols. Not identical with EC 2.1.1.9 thiol S-methyltransferase.
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| Pathway |
| Drug metabolism - other enzymes |
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| Orthology |
| thiopurine S-methyltransferase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | ISC: | | NVE: | | TAD: | | AQU: | | YLI: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XCI: | | PSU: | | PSD: | | RHD: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | VFI: | | VFM: | | VSA: | | PPR: | | VAN: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | PDR: | | AVN: | | AVL: | | AVD: | | PCR: | | PRW: | | ACI: | | SON: | | SDN: | | SFR: | | SAZ: | | SBL: | | SBM: | | SBN: | | SBP: | | SBT: | | SBS: | | SBB: | | SLO: | | SPC: | | SHP: | | SSE: | | SPL: | | SHE: | | SHM: | | SHN: | | SHW: | | SHL: | | SWD: | | SWP: | | SVO: | | CPS: | | PAT: | | MAQ: | | MHC: | | MAD: | | MBS: | | AMC: | | AMAC: | | AMB: | | AMG: | | AMK: | | AMAA: | | ALT: | | GAG: | | GNI: | | PSY: | | TTU: | | FBL: | | LPN: | | LPU: | | LPF: | | LPP: | | LPC: | | LPA: | | LPE: | | MCA: | | MMT: | | MAH: | | FTU: | | FTF: | | FTW: | | FTR: | | FTT: | | FTG: | | FTL: | | FTH: | | FTA: | | FTS: | | FTI: | | FTM: | | FTN: | | FCF: | | FCN: | | FPH: | | FRT: | | TCX: | | CYQ: | | ALV: | | TVI: | | TMB: | | HCH: | | CSA: | | HEL: | | ADI: | | KKO: | | MMW: | | MME: | | MPC: | | TOL: | | AHA: | | ASA: | | AVR: | | TAU: | | OCE: | | SAGA: | | GPB: | | REH: | | BPE: | | BPC: | | BPER: | | BPA: | | BPAR: | | BBR: | | BBM: | | BBH: | | BPT: | | BAV: | | AXY: | | PUT: | | HSE: | | CFU: | | NET: | | NII: | | NMU: | | AZA: | | DAR: | | MMB: | | MEH: | | MEI: | | MEP: | | SLT: | | ARC: | | BMX: | | HOH: | | XAU: | | SNO: | | HDN: | | HMC: | | GOX: | | GXY: | | APT: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | TMO: | | MGM: | | AMI: | | LBJ: | | SLI: | | GFO: | | SYX: | | CEP: | | HAU: | | NDE: | |
» show all
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| Reference |
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| Authors |
REMY CN. |
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| Title |
Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues. |
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| Journal |
J. Biol. Chem. 238 (1963) 1078-84. |
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| Organism |
Rattus norvegicus [GN: rno], Escherichia coli [GN: eco] |
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| Reference |
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| Authors |
Woodson LC, Ames MM, Selassie CD, Hansch C, Weinshilboum RM. |
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| Title |
Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives. |
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| Journal |
Mol. Pharmacol. 24 (1983) 471-8. |
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| Organism |
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| Reference |
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| Authors |
Woodson LC, Weinshilboum RM. |
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| Title |
Human kidney thiopurine methyltransferase. Purification and biochemical properties. |
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| Journal |
Biochem. Pharmacol. 32 (1983) 819-26. |
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| Organism |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 67339-09-7 |
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