| Entry |
|
|---|
| Name |
caffeate O-methyltransferase;
caffeate methyltransferase;
caffeate 3-O-methyltransferase;
S-adenosyl-L-methionine:caffeic acid-O-methyltransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate
3-O-methyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate =
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate
[RN:R03366] |
|---|
| Reaction(KEGG) |
R03366;
(other) R02379 R06574 R06575 R06576 R06577
 |
|---|
| Substrate |
S-adenosyl-L-methionine [CPD:C00019];
3,4-dihydroxy-trans-cinnamate [CPD:C01197] |
|---|
| Product |
S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-4-hydroxy-trans-cinnamate [CPD:C01494] |
|---|
| Comment |
3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but
more slowly. |
|---|
| Pathway |
PATH: ec00940 Phenylpropanoid biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway |
|---|
| Orthology |
KO: K13066 caffeic acid 3-O-methyltransferase |
|---|
| Genes |
POP: POPTR_824484(COMT1)
 |
|---|
| Structures |
PDB: 1KYW 1KYZ |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4472044]
Ebel J, Schaller-Hekeler B, Knobloch KH, Wellman E, Grisebach H,
Hahlbrock K.
Coordinated changes in enzyme activities of phenylpropanoid
metabolism during the growth of soybean cell suspension cultures.
Biochim. Biophys. Acta. 362 (1974) 417-24.
Glycine max |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:241400]
Poulton JE, Butt VS.
Purification and properties of S-adenosyl-L-methionine: caffeic acid
O-methyltransferase from leaves of spinach beet (Beta vulgaris L).
Biochim. Biophys. Acta. 403 (1975) 301-14.
Beta vulgaris |
|---|
Reference
Authors
Title
Journal
|
3
Shimada, M., Kuroda, H. and Higuchi, T.
Evidence for the formation of methoxyl groups of ferulic and sinapic
acid in Bambusa by the same O-methyltransferase.
Phytochemistry 12 (1973) 2873-2875. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.1.68
IUBMB Enzyme Nomenclature: 2.1.1.68
ExPASy - ENZYME nomenclature database: 2.1.1.68
BRENDA, the Enzyme Database: 2.1.1.68
CAS: 50936-45-3 |
|---|
