KEGG ENZYME: 2.1.1.68

ENZYME: 2.1.1.68

Entry

EC 2.1.1.68 Enzyme

Name

caffeate O-methyltransferase;
caffeate methyltransferase;
caffeate 3-O-methyltransferase;
S-adenosyl-L-methionine:caffeic acid-O-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate [RN:R03366]

Reaction(KEGG)

R03366;
(other) R02379 R06574 R06575 R06576 R06577

Substrate

S-adenosyl-L-methionine [CPD:C00019];
3,4-dihydroxy-trans-cinnamate [CPD:C01197]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-4-hydroxy-trans-cinnamate [CPD:C01494]

Comment

3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly.

History

EC 2.1.1.68 created 1984

Pathway

ec00940	Phenylpropanoid biosynthesis
ec01100	Metabolic pathways
ec01110	Biosynthesis of secondary metabolites

Orthology

K13066

caffeic acid 3-O-methyltransferase

Genes

ATH:	AT5G54160(OMT1)
ALY:	ARALYDRAFT_495497(ATOMT1)
CRB:	CARUB_v10026645mg
EUS:	EUTSA_v10013897mg
CIT:	102629858
CIC:	CICLE_v10024037mg
TCC:	TCM_015522
GMX:	100780100
PVU:	PHAVU_009G044400g
MTR:	MTR_3g092900
CAM:	101489645
FVE:	101308514
PPER:	PRUPE_ppa007511mg
CSV:	101204109
RCU:	RCOM_0596300
POP:	POPTR_0012s00670g(POPTRDRAFT_834247) POPTR_0015s00550g(POPTRDRAFT_824484)
VVI:	100854172
SLY:	101251452
ZMA:	100125646(comt)
SITA:	101765311
ATR:	s00001p00272250(AMTR_s00001p00272250)

» show all

Reference

1 [PMID:4472044]

Authors

Ebel J, Schaller-Hekeler B, Knobloch KH, Wellman E, Grisebach H, Hahlbrock K.

Title

Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures.

Journal

Biochim. Biophys. Acta. 362 (1974) 417-24.

Organism

Glycine max

Reference

2 [PMID:241400]

Authors

Poulton JE, Butt VS.

Title

Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L).

Journal

Biochim. Biophys. Acta. 403 (1975) 301-14.

Organism

Beta vulgaris

Reference

Authors

Shimada, M., Kuroda, H. and Higuchi, T.

Title

Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase.

Journal

Phytochemistry 12 (1973) 2873-2875.

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.68

IUBMB Enzyme Nomenclature:

2.1.1.68

ExPASy - ENZYME nomenclature database:

2.1.1.68

BRENDA, the Enzyme Database:

2.1.1.68

CAS:

50936-45-3

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (26)   
   KEGG PATHWAY (7)   
   KEGG MODULE (19)   
Chemical substance (14)   
   KEGG COMPOUND (14)   
Chemical reaction (21)   
   KEGG REACTION (6)   
   KEGG RPAIR (13)   
   KEGG RCLASS (2)   
Gene (69)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (22)   
   KEGG DGENES (46)   
Protein sequence (102)   
   UniProt (50)   
   SWISS-PROT (21)   
   RefSeq(pep) (17)   
   PDBSTR (12)   
   PMD (2)   
DNA sequence (90)   
   RefSeq(nuc) (28)   
   GenBank (31)   
   EMBL (31)   
3D Structure (4)   
   PDB (4)   
Protein domain (1)   
   PROSITE(DOC) (1)   
Literature (2)   
   PubMed (2)   
Enzyme (4)   
   BRENDA (1)   
   EXPASY-ENZYME (1)   
   EXPLORENZ (1)   
   IUBMB (1)   
All databases (336)   

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