KEGG ENZYME: 2.1.1.68

ENZYME: 2.1.1.68

Entry

EC 2.1.1.68 Enzyme

Name

caffeate O-methyltransferase;
caffeate methyltransferase;
caffeate 3-O-methyltransferase;
S-adenosyl-L-methionine:caffeic acid-O-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate [RN:R03366]

Reaction(KEGG)

R03366;
(other) R02379 R06574 R06575 R06576 R06577

Substrate

S-adenosyl-L-methionine [CPD:C00019];
3,4-dihydroxy-trans-cinnamate [CPD:C01197]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-4-hydroxy-trans-cinnamate [CPD:C01494]

Comment

3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly.

History

EC 2.1.1.68 created 1984

Pathway

ec00940	Phenylpropanoid biosynthesis
ec01100	Metabolic pathways
ec01110	Biosynthesis of secondary metabolites

Orthology

K13066

caffeic acid 3-O-methyltransferase

Genes

ATH:	AT5G54160(OMT1)
ALY:	ARALYDRAFT_495497(ATOMT1)
CRB:	17876808
EUS:	EUTSA_v10013897mg
CIT:	102629858
CIC:	CICLE_v10001661mg CICLE_v10024037mg CICLE_v10031951mg
DZI:	111279932 111289581
GMX:	100780100 100805999 100806525
PVU:	PHAVU_009G044400g
MTR:	MTR_3g092900
CAM:	101489645
FVE:	101308514
PMUM:	103333559
MDM:	103439955
CSV:	101204109
CMO:	103501180
CMOS:	111450048
RCU:	8282965
POP:	7464476 7493466
JRE:	109007527
VVI:	100232862 100242108 100260786 100854172
SLY:	101251452
SOT:	102601955
OEU:	111367736
SMO:	SELMODRAFT_450944(COMT1-1) SELMODRAFT_450945(COMT1-2)

» show all

Reference

1 [PMID:4472044]

Authors

Ebel J, Schaller-Hekeler B, Knobloch KH, Wellman E, Grisebach H, Hahlbrock K.

Title

Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures.

Journal

Biochim. Biophys. Acta. 362 (1974) 417-24.

Reference

2 [PMID:241400]

Authors

Poulton JE, Butt VS.

Title

Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L).

Journal

Biochim. Biophys. Acta. 403 (1975) 301-14.

Reference

Authors

Shimada, M., Kuroda, H. and Higuchi, T.

Title

Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase.

Journal

Phytochemistry 12 (1973) 2873-2875.

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.68

IUBMB Enzyme Nomenclature:

2.1.1.68

ExPASy - ENZYME nomenclature database:

2.1.1.68

BRENDA, the Enzyme Database:

2.1.1.68

CAS:

50936-45-3

All links

Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (14)   
   KEGG COMPOUND (14)   
Chemical reaction (8)   
   KEGG REACTION (6)   
   KEGG RCLASS (2)   
Gene (42)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (35)   
   KEGG MGENES (6)   
Protein sequence (120)   
   UniProt (79)   
   SWISS-PROT (22)   
   RefSeq(pep) (5)   
   PDBSTR (12)   
   PMD (2)   
DNA sequence (81)   
   RefSeq(nuc) (8)   
   GenBank (47)   
   EMBL (26)   
3D Structure (4)   
   PDB (4)   
Protein domain (1)   
   PROSITE(DOC) (1)   
All databases (277)   

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