KEGG   ENZYME: 2.1.1.68Help
Entry
EC 2.1.1.68                 Enzyme                                 

Name
caffeate O-methyltransferase;
caffeate methyltransferase;
caffeate 3-O-methyltransferase;
S-adenosyl-L-methionine:caffeic acid-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate [RN:R03366]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3,4-dihydroxy-trans-cinnamate [CPD:C01197]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-4-hydroxy-trans-cinnamate [CPD:C01494]
Comment
3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly.
History
EC 2.1.1.68 created 1984
Pathway
Phenylpropanoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13066  
caffeic acid 3-O-methyltransferase
Genes
ATH: 
AT5G54160(OMT1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
105763982 105765366 105765367 105765368 105765408 105767646 105777756 105778083 105778084 105782479 105786164 105791250 105792628 105792629 105793470 105799382
EGR: 
104415145 104415146 104416154 104416155 104416156 104416157 104416158 104416159 104416162 104417513 104420045 104424243 104424567 104429247 104429248 104430810 104430849 104437195 104437201 104437219 104439341 104444139 104445297 104445600 104445601 104446176 104447135 104447137 104447142 104447255 104447523 104449485 104449526 104449527 104449528 104450510 104452413 104452416 104455705 104455715 104456234
GMX: 
100777636 100779492 100780100 100784030 100787536 100788873 100793053 100798295 100798347 100802593 100803633 106794104
PVU: 
PHAVU_003G006000g PHAVU_003G006100g PHAVU_003G006200g PHAVU_005G0323000 PHAVU_007G090100g PHAVU_007G091000g PHAVU_008G040200g PHAVU_009G044400g PHAVU_009G258700g PHAVU_009G258800g PHAVU_009G258900g PHAVU_009G259000g PHAVU_009G259100g PHAVU_009G259200g PHAVU_009G259300g PHAVU_009G259500g PHAVU_010G120200g PHAVU_L008600g
VRA: 
106753579 106759043 106760167 106760169 106760548 106764425 106766344 106772242 106772244
MTR: 
MTR_1g036460 MTR_1g036490 MTR_1g036510 MTR_1g050220 MTR_1g096310 MTR_2g055940 MTR_3g021430 MTR_3g021440 MTR_3g092900 MTR_5g098170 MTR_6g060290 MTR_6g078850 MTR_7g011900 MTR_7g011990 MTR_7g012020 MTR_7g012040 MTR_7g012070 MTR_7g012090 MTR_7g118310 MTR_8g068570
CAM: 
101489515 101489645 101492092 101502419 101512074 101512403 101514542 101514683
ADU: 
107458050 107470102 107470446 107471785 107471786 107471788 107471789 107471790 107473073 107473077 107488816 107491547
AIP: 
107606821 107609676 107619633 107621172 107622469 107622470 107622471 107622472 107622473 107622793 107624476 107626705 107642249 107643318
LJA: 
Lj0g3v0034909.1(Lj0g3v0034909.1) Lj0g3v0124669.1(Lj0g3v0124669.1) Lj0g3v0273599.1(Lj0g3v0273599.1) Lj0g3v0306659.1(Lj0g3v0306659.1) Lj0g3v0346019.1(Lj0g3v0346019.1) Lj0g3v0354359.1(Lj0g3v0354359.1) Lj0g3v0364049.1(Lj0g3v0364049.1) Lj1g3v1079700.1(Lj1g3v1079700.1) Lj1g3v2994540.1(Lj1g3v2994540.1) Lj1g3v2994540.2(Lj1g3v2994540.2) Lj1g3v5060810.1(Lj1g3v5060810.1) Lj1g3v5060810.2(Lj1g3v5060810.2) Lj2g3v3339490.1(Lj2g3v3339490.1) Lj5g3v1853310.1(Lj5g3v1853310.1) Lj5g3v1853430.1(Lj5g3v1853430.1)
FVE: 
101292538 101294295 101296734 101296885 101308514 101314449
PPER: 
PRUPE_ppa007212mg PRUPE_ppa007229mg PRUPE_ppa007511mg PRUPE_ppa015120mg PRUPE_ppa015423mg PRUPE_ppa015896mg PRUPE_ppa019437mg PRUPE_ppa019499mg PRUPE_ppa021447mg
PMUM: 
103319810 103322531 103325170 103333559 103342357 103342358 103342359(OMT1) 103342360 103343871
MDM: 
103406240 103406241 103410332 103410396 103411915 103420798 103420847 103421923(OMT2) 103422036 103426402 103426499 103426529(omt1) 103426534 103428516 103428558 103429450 103429452 103431087 103431107 103435029 103439955 103439956 103439958 103443723(omt2) 103444096 103444340(OMT6) 103445678 108172651
PXB: 
103935025 103935026 103940328 103943351 103943352 103943506 103951323 103951351 103951352 103951568 103951571 103951572 103951578 103951641 103956347 103966079 103966114
CSV: 
101204109 101205290 101210788 101214675 101214916
CMO: 
103491014 103491140 103501180 103503246 107990280 107990972
RCU: 
8262723 8270912 8270961 8270962 8282965 8285506 8288877
JCU: 
105631282 105631656 105632993 105634486 105635102 105635946 105636072 105639044 105639046 105641383 105646425
POP: 
POPTR_0001s45530g(POPTRDRAFT_550470) POPTR_0002s07730g POPTR_0002s18120g POPTR_0002s18130g POPTR_0002s18150g(POPTRDRAFT_552360) POPTR_0002s18160g(POPTRDRAFT_799151) POPTR_0005s20630g POPTR_0011s15360g(POPTRDRAFT_806142) POPTR_0012s00670g(POPTRDRAFT_834247) POPTR_0014s10210g(POPTRDRAFT_774571) POPTR_0014s10220g(POPTRDRAFT_731466) POPTR_0015s00550g(POPTRDRAFT_824484) POPTR_0016s10450g POPTR_0019s11400g
VVI: 
100232921(COMT) 100255690 100260649 100260763 100265214 100265976 100265990 100854172 104882673
SLY: 
101247834 101251452 101258157 101261963(CTOMT1) 101262824
SPEN: 
107002798 107015050 107021224 107022691 107023557 107023901
SOT: 
102590869 102598963 102599285 102599938 102601955 107058365
SIND: 
105155388 105155389 105155459 105155460 105155461 105156074 105160270 105166789 105166790 105166791 105166792 105166793 105171204 105176053
BVG: 
104887972 104888149 104888150 104888557 104893230 104901566 104901641 104901795 104902234 104907961 104908865
NNU: 
104585771 104586605 104590656 104590659 104596816 104600131 104601399 104604834
DOSA: 
Os04t0175900-01(Os04g0175900) Os12t0199500-00(Os12g0199500) Os12t0202700-00(Os12g0202700) Os12t0240900-00(Os12g0240900)
OBR: 
102717362 102719765
BDI: 
100833782 100838174 100842290
ATS: 
F775_06936 F775_07800 F775_07801 F775_10047 F775_14227 F775_17739 F775_18115 F775_19652 F775_20925 F775_26153 F775_26154 F775_31276 F775_32449
SBI: 
SORBI_01g015803(SORBIDRAFT_01g015803) SORBI_01g033245(SORBIDRAFT_01g033245) SORBI_01g042900(SORBIDRAFT_01g042900) SORBI_07g004680(SORBIDRAFT_07g004680)
ZMA: 
100125646(comt) 101027166 103640406(GRMZM2G423331)
SITA: 
101754689 101761321 101765311 101772386 101783292
PDA: 
103696092 103706414 103716997
EGU: 
105037617 105042923 105054950 105054951 105054993 105054994
MUS: 
103971889 103971898 103971905 103971914 103971925 103971934 103971944 103971953 103971962 103972218 103972714 103973475 103973830 103973854 103973864 103973874 103973932 103974217 103974740 103974741 103974791 103974925 103975177 103978658 103980348 103982815 103998763 103998764 103998765 103999438 104000428
ATR: 
18424568
SMO: 
SELMODRAFT_112597 SELMODRAFT_124122 SELMODRAFT_124205 SELMODRAFT_134942 SELMODRAFT_134972 SELMODRAFT_227279 SELMODRAFT_227505 SELMODRAFT_76630 SELMODRAFT_78541 SELMODRAFT_83100 SELMODRAFT_85724 SELMODRAFT_85878 SELMODRAFT_94918 SELMODRAFT_96831 SELMODRAFT_97635
 » show all
Taxonomy
Reference
1  [PMID:4472044]
  Authors
Ebel J, Schaller-Hekeler B, Knobloch KH, Wellman E, Grisebach H, Hahlbrock K.
  Title
Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures.
  Journal
Biochim. Biophys. Acta. 362 (1974) 417-24.
Reference
2  [PMID:241400]
  Authors
Poulton JE, Butt VS.
  Title
Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L).
  Journal
Biochim. Biophys. Acta. 403 (1975) 301-14.
Reference
3
  Authors
Shimada, M., Kuroda, H. and Higuchi, T.
  Title
Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase.
  Journal
Phytochemistry 12 (1973) 2873-2875.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
50936-45-3
DBGET integrated database retrieval system