| Entry |
|
|---|
| Name |
phosphatidyl-N-methylethanolamine N-methyltransferase;
phosphatidylmonomethylethanolamine methyltransferase;
methyltransferase II;
phospholipid methyltransferase;
PLMT;
phosphatidyl-N-methylethanolamine methyltransferase;
phosphatidyl-N-monomethylethanolamine methyltransferase;
phosphatidylethanolamine methyltransferase I;
phosphatidylmonomethylethanolamine methyltransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine
N-methyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine =
S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine
[RN:R03424] |
|---|
| Reaction(KEGG) |
R03424;
(other) R01320
 |
|---|
| Substrate |
S-adenosyl-L-methionine [CPD:C00019];
phosphatidyl-N-methylethanolamine [CPD:C01241] |
|---|
| Product |
S-adenosyl-L-homocysteine [CPD:C00021];
phosphatidyl-N-dimethylethanolamine [CPD:C04308] |
|---|
| Comment |
The enzyme also catalyses the transfer of a further methyl group,
producing phosphatidylcholine. |
|---|
| Pathway |
PATH: ec00564 Glycerophospholipid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00570 phosphatidyl-N-methylethanolamine N-methyltransferase |
|---|
| Genes |
CME: CMA134C
AEH: Mlg_0492
RET: RHE_CH00316(ypch00118)
RLE: RL0333(pmtA)
BME: BMEI2000
BOV: BOV_2043(pmtA)
SIT: TM1040_3086
GBE: GbCGDNIH1_0800 GbCGDNIH1_2260
MTA: Moth_0018
NCA: Noca_2195 Noca_3328
TFU: Tfu_0735
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:25437]
Hirata F, Viveros OH, Diliberto EJ Jr, Axelrod J.
Identification and properties of two methyltransferases in
conversion of phosphatidylethanolamine to phosphatidylcholine.
Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 1718-21.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:438165]
Schneider WJ, Vance DE.
Conversion of phosphatidylethanolamine to phosphatidylcholine in rat
liver. Partial purification and characterization of the enzymatic
activities.
J. Biol. Chem. 254 (1979) 3886-91.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.1.71
IUBMB Enzyme Nomenclature: 2.1.1.71
ExPASy - ENZYME nomenclature database: 2.1.1.71
BRENDA, the Enzyme Database: 2.1.1.71
CAS: 67167-73-1 |
|---|
