| Entry |
|
|---|
| Name |
quercetin 3-O-methyltransferase;
flavonol 3-O-methyltransferase;
flavonoid 3-methyltransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone
3-O-methyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone =
S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone
[RN:R02157] |
|---|
| Reaction(KEGG) |
R02157;
(other) R05035
 |
|---|
| Substrate |
S-adenosyl-L-methionine [CPD:C00019];
3,5,7,3',4'-pentahydroxyflavone [CPD:C00389] |
|---|
| Product |
S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443] |
|---|
| Comment |
Specific for quercetin. Related enzymes bring about the
3-O-methylation of other flavonols, such as galangin and kaempferol. |
|---|
| Pathway |
PATH: ec00944 Flavone and flavonol biosynthesis |
|---|
| Orthology |
KO: K05279 flavonol 3-O-methyltransferase |
|---|
| Genes |
ATH: AT5G54160(ATOMT1)
OSA: 4344702(Os08g0157500)
 |
|---|
Reference
Authors
Title
Journal
|
1
De Luca, V., Brunet, G., Khouri, H., Ibrahim, R. and Hrazdina, G.
Flavonol 3-O-methyltransferase in plant-tissues.
Z. Naturforsch. 37 (1982) 134-135. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3994393]
De Luca V, Ibrahim RK.
Enzymatic synthesis of polymethylated flavonols in Chrysosplenium
americanum. I. Partial purification and some properties of
S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and
4'-O-methyltransferases.
Arch. Biochem. Biophys. 238 (1985) 596-605.
Chrysosplenium americanum |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:3994394]
De Luca V, Ibrahim RK.
Enzymatic synthesis of polymethylated flavonols in Chrysosplenium
americanum. II. Substrate interaction and product inhibition studies
of flavonol 3-, 6-, and 4'-O-methyltransferases.
Arch. Biochem. Biophys. 238 (1985) 606-18.
Chrysosplenium americanum |
|---|
Reference
Authors
Title
Journal
|
4
Ibrahim, R.K. and De Luca, V.
Polymethylated flavonol synthesis is catalyzed by distinct
O-methyltransferases.
Naturwissenschaften 69 (1982) 41-42. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.1.76
IUBMB Enzyme Nomenclature: 2.1.1.76
ExPASy - ENZYME nomenclature database: 2.1.1.76
BRENDA, the Enzyme Database: 2.1.1.76
CAS: 81295-55-8 |
|---|
