KEGG   ENZYME: 2.1.1.8Help
Entry
EC 2.1.1.8                  Enzyme                                 

Name
histamine N-methyltransferase;
histamine 1-methyltransferase;
histamine methyltransferase;
histamine-methylating enzyme;
imidazolemethyltransferase;
S-adenosylmethionine-histamine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:histamine N-tele-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Ntau-methylhistamine [RN:R02155]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
histamine [CPD:C00388]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
Ntau-methylhistamine [CPD:C05127]
History
EC 2.1.1.8 created 1965
Pathway
Histidine metabolism
Orthology
K00546  
histamine N-methyltransferase
Genes
HSA: 
3176(HNMT)
PTR: 
742204(HNMT)
PPS: 
100970136(HNMT)
GGO: 
101141216(HNMT)
PON: 
100174618(HNMT)
MCC: 
703857(HNMT) 706713(HNMT)
MCF: 
MMU: 
140483(Hnmt)
RNO: 
81676(Hnmt)
CGE: 
HGL: 
TUP: 
CFA: 
476133(HNMT)
AML: 
FCA: 
101093704(HNMT)
PTG: 
102954667(HNMT)
BTA: 
613413(HNMT)
BOM: 
102279160(HNMT)
PHD: 
102317487(HNMT)
CHX: 
102169059(HNMT)
OAS: 
101102876(HNMT)
SSC: 
100624677(HNMT)
CFR: 
BACU: 
102997526(HNMT)
LVE: 
103075160(HNMT)
ECB: 
100051119(HNMT)
MYB: 
MYD: 
PALE: 
102888765(HNMT)
MDO: 
SHR: 
100914453(HNMT)
OAA: 
GGA: 
424298(HNMT)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
102087354(HNMT)
ASN: 
AMJ: 
PSS: 
102449429(HNMT)
CMY: 
102948037(HNMT)
ACS: 
PBI: 
XLA: 
380306(hnmt-b) 495426(hnmt-a)
XTR: 
779808(hnmt)
DRE: 
445242(hnmt)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103180417(hnmt)
BFO: 
SPU: 
NVE: 
HMG: 
 » show all
Taxonomy
Reference
1  [PMID:13804910]
  Authors
BROWN DD, TOMCHICK R, AXELROD J.
  Title
The distribution and properties of a histamine-methylating enzyme.
  Journal
J. Biol. Chem. 234 (1959) 2948-50.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-80-5

DBGET integrated database retrieval system