| Entry |
|
|---|
| Name |
glutamate formimidoyltransferase;
glutamate formyltransferase;
formiminoglutamic acid transferase;
formiminoglutamic formiminotransferase;
glutamate formiminotransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
 |
|---|
| Sysname |
5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase |
|---|
| Reaction(IUBMB) |
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate +
N-formimidoyl-L-glutamate [RN:R02287] |
|---|
| Reaction(KEGG) |
R02287;
(other) R03189
 |
|---|
| Substrate |
5-formimidoyltetrahydrofolate [CPD:C00664];
L-glutamate [CPD:C00025] |
|---|
| Product |
tetrahydrofolate [CPD:C00101];
N-formimidoyl-L-glutamate [CPD:C00439] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. Also catalyses formyl transfer from
5-formyltetrahydrofolate to L-glutamate (a reaction formerly listed
as EC 2.1.2.6). In eukaryotes, it occurs as a bifunctional enzyme
that also has formimidoyltetrahydrofolate cyclodeaminase (EC
4.3.1.4) activity. |
|---|
| Pathway |
PATH: ec00340 Histidine metabolism
PATH: ec00670 One carbon pool by folate
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00603 glutamate formiminotransferase |
|---|
| Genes |
HSA: 10841(FTCD)
MMU: 14317(Ftcd)
RNO: 89833(Ftcd)
CFA: 607685
SSC: 397517(FTCD)
ECB: 100049972
GGA: 395726(FTCD)
TGU: 100221117
XLA: 379483
XTR: 448617(TGas028n11.1)
DRE: 394052
SPU: 584654
NVE: NEMVE_v1g162049
DDI: DDBDRAFT_0187716
DPS: DP2350
SAT: SYN_00461
SPZ: M5005_Spy_1772
SPH: MGAS10270_Spy1838
SPI: MGAS10750_Spy1864
SPJ: MGAS2096_Spy1805
SPK: MGAS9429_Spy1783
SPF: SpyM51730
SPA: M6_Spy1769
SPB: M28_Spy1756
SSA: SSA_0434
SGO: SGO_1806(ftcD) SGO_1807
CTC: CTC02305
AMT: Amet_4073
TTE: TTE0450
CHY: CHY_0695(ftcD)
TDE: TDE0296
SUS: Acid_5208
BFR: BF4147
BFS: BF3969(ftcD)
PGI: PG0329
FNU: FN0741 FN1407
TPT: Tpet_0084
PMO: Pmob_0241
PTO: PTO1242
 |
|---|
| Structures |
PDB: 1QD1 1TT9 2PFD |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13475327]
MILLER A, WAELSCH H.
Formimino transfer from formamidinoglutaric acid to tetrahydrofolic
acid.
J. Biol. Chem. 228 (1957) 397-417.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13428739]
SILVERMAN M, KERESZTESY JC, KOVAL GJ, GARDINER RC.
Citrovorum factor and the synthesis of formylglutamic acid.
J. Biol. Chem. 226 (1957) 83-94.
Equus caballus [GN:ecb] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13672973]
TABOR H, WYNGARDEN L.
The enzymatic formation of formiminotetrahydrofolic acid,
5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid
in the metabolism of formiminoglutamic acid.
J. Biol. Chem. 234 (1959) 1830-46.
Sus scofa [GN:ssc], Oryctolagus cuniculus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.2.5
IUBMB Enzyme Nomenclature: 2.1.2.5
ExPASy - ENZYME nomenclature database: 2.1.2.5
BRENDA, the Enzyme Database: 2.1.2.5
CAS: 9032-83-1 |
|---|
