| Entry |
|
|---|
| Name |
deoxycytidylate 5-hydroxymethyltransferase;
dCMP hydroxymethylase;
d-cytidine 5'-monophosphate hydroxymethylase;
deoxyCMP hydroxymethylase;
deoxycytidylate hydroxymethylase;
deoxycytidylic hydroxymethylase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
 |
|---|
| Sysname |
5,10-methylenetetrahydrofolate:deoxycytidylate
5-hydroxymethyltransferase |
|---|
| Reaction(IUBMB) |
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate =
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate [RN:R01669] |
|---|
| Reaction(KEGG) |
R01669
 |
|---|
| Substrate |
5,10-methylenetetrahydrofolate [CPD:C00143];
H2O [CPD:C00001];
deoxycytidylate [CPD:C00239] |
|---|
| Product |
tetrahydrofolate [CPD:C00101];
5-hydroxymethyldeoxycytidylate [CPD:C03997] |
|---|
| Pathway |
PATH: ec00240 Pyrimidine metabolism
PATH: ec00670 One carbon pool by folate |
|---|
| Structures |
PDB: 1B49 1B5D 1B5E |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14217882]
MATHEWS CK, BROWN F, COHEN SS.
VIRUS-INDUCED ACQUISITION OF METABOLIC FUNCTION. VII. BIOSYNTHESIS
DE NOVO OF DEOXYCYTIDYLATE HYDROXYMETHYLASE.
J. Biol. Chem. 239 (1964) 2957-63.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.2.8
IUBMB Enzyme Nomenclature: 2.1.2.8
ExPASy - ENZYME nomenclature database: 2.1.2.8
BRENDA, the Enzyme Database: 2.1.2.8
CAS: 9012-68-4 |
|---|
