KEGG   ENZYME: 2.1.2.8Help
Entry
EC 2.1.2.8                  Enzyme                                 

Name
deoxycytidylate 5-hydroxymethyltransferase;
dCMP hydroxymethylase;
d-cytidine 5'-monophosphate hydroxymethylase;
deoxyCMP hydroxymethylase;
deoxycytidylate hydroxymethylase;
deoxycytidylic hydroxymethylase
Class
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
BRITE hierarchy
Sysname
5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase
Reaction(IUBMB)
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate [RN:R01669]
Reaction(KEGG)
Substrate
5,10-methylenetetrahydrofolate [CPD:C00143];
H2O [CPD:C00001];
deoxycytidylate [CPD:C00239]
Product
tetrahydrofolate [CPD:C00101];
5-hydroxymethyldeoxycytidylate [CPD:C03997]
History
EC 2.1.2.8 created 1972
Pathway
Pyrimidine metabolism
One carbon pool by folate
Reference
1  [PMID:14217882]
  Authors
MATHEWS CK, BROWN F, COHEN SS.
  Title
VIRUS-INDUCED ACQUISITION OF METABOLIC FUNCTION. VII. BIOSYNTHESIS DE NOVO OF DEOXYCYTIDYLATE HYDROXYMETHYLASE.
  Journal
J. Biol. Chem. 239 (1964) 2957-63.
  Organism
Escherichia coli
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-68-4

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