KEGG   ENZYME: 2.1.3.9Help
Entry
EC 2.1.3.9                  Enzyme                                 
Name
N-acetylornithine carbamoyltransferase;
acetylornithine transcarbamylase;
N-acetylornithine transcarbamylase;
AOTC;
carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase;
AOTCase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline [RN:R07245]
Reaction(KEGG)
Substrate
carbamoyl phosphate [CPD:C00169];
N2-acetyl-L-ornithine [CPD:C00437]
Product
phosphate [CPD:C00009];
N-acetyl-L-citrulline [CPD:C15532]
Comment
Differs from EC 2.1.3.3, ornithine carbamoyltransferase. This enzyme replaces EC 2.1.3.3 in the canonic arginine biosynthetic pathway of several Eubacteria and has no catalytic activity with L-ornithine as substrate.
Pathway
Arginine and proline metabolism
Orthology
K09065  
N-acetylornithine carbamoyltransferase
Genes
XFA: 
XFT: 
PD0290(argF)
XFM: 
XFN: 
XCC: 
XCC2249(argF)
XCB: 
XCA: 
XCV: 
XCV2551(argF)
XAC: 
XAC2352(argF)
XOO: 
XOO2676(argF)
XOM: 
XOO_2522
XOP: 
PXO_00353
XAL: 
XALc_1896(argF)
SML: 
Smlt3302
SMT: 
Smal_2729
PSU: 
Psesu_1224
FAU: 
Fraau_2115
KKO: 
Kkor_0543
MXA: 
MXAN_5104(argF)
MFU: 
LILAB_33450
SUR: 
STAUR_5869(argF)
SCL: 
sce0074(argF1)
MMR: 
Mmar10_0364
PBR: 
PB2503_11074
CTM: 
Cabther_B0219
SRU: 
SRU_2218
SRM: 
SRM_02445(argF)
RMR: 
Rmar_0946
 » show all
Taxonomy
Reference
1  [PMID:15731101]
  Authors
Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M.
  Title
Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria.
  Journal
J. Biol. Chem. 280 (2005) 14366-9.
  Organism
Xanthomonas campestris
Reference
2  [PMID:16585758]
  Authors
Morizono H, Cabrera-Luque J, Shi D, Gallegos R, Yamaguchi S, Yu X, Allewell NM, Malamy MH, Tuchman M.
  Title
Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis.
  Journal
J. Bacteriol. 188 (2006) 2974-82.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
890853-54-0
DBGET integrated database retrieval system