KEGG   ENZYME: 2.1.4.1Help
Entry
EC 2.1.4.1                  Enzyme                                 

Name
glycine amidinotransferase;
arginine-glycine amidinotransferase;
arginine-glycine transamidinase;
glycine transamidinase
Class
Transferases;
Transferring one-carbon groups;
Amidinotransferases
BRITE hierarchy
Sysname
L-arginine:glycine amidinotransferase
Reaction(IUBMB)
L-arginine + glycine = L-ornithine + guanidinoacetate [RN:R00565]
Reaction(KEGG)
R00565;
(other) R01686 R01989
Show
Substrate
L-arginine [CPD:C00062];
glycine [CPD:C00037]
Product
L-ornithine [CPD:C00077];
guanidinoacetate [CPD:C00581]
Comment
Canavanine can act instead of arginine.
Pathway
Glycine, serine and threonine metabolism
Arginine and proline metabolism
Metabolic pathways
Orthology
K00613  
glycine amidinotransferase
Genes
HSA: 
2628(GATM)
PTR: 
453401(GATM)
PPS: 
100982293(GATM)
GGO: 
101144802(GATM)
PON: 
100171513(GATM)
MCC: 
713306(GATM)
MMU: 
67092(Gatm)
RNO: 
81660(Gatm)
CFA: 
414733(GATM)
AML: 
FCA: 
414734(GATM)
BTA: 
414732(GATM)
SSC: 
100126844(GATM)
ECB: 
100070511(GATM)
MDO: 
100012229(GATM)
SHR: 
100933609(GATM)
OAA: 
GGA: 
395504(GATM)
MGP: 
TGU: 
ACS: 
XLA: 
379386(gatm)
XTR: 
394568(gatm)
DRE: 
266799(gatm)
TRU: 
OLA: 
BFO: 
CIN: 
SPU: 
SMM: 
NVE: 
AQU: 
SMP: 
CIM: 
CPW: 
URE: 
PIF: 
EPY: 
EpC_01150(hsvA) EpC_31010(hsvA)
EPR: 
EAM: 
EAMY_0520(hsvA)
EAY: 
EAM_2910(hsvA)
ERJ: 
PLU: 
PAY: 
XNE: 
PPR: 
PST: 
PSP: 
SHL: 
PSY: 
LHK: 
BGD: 
PUB: 
BJU: 
NWI: 
MRD: 
MET: 
MPO: 
BID: 
MSC: 
JAN: 
RDE: 
RD1_1472(gatM)
APM: 
SBH: 
SDV: 
PAC: 
PAK: 
PAV: 
PAX: 
PAZ: 
PAW: 
PAD: 
PCN: 
PACC: 
PACH: 
SEN: 
AMD: 
AMN: 
AMM: 
AMI: 
SAQ: 
MCU: 
CWO: 
CCU: 
ELE: 
EYY: 
GPA: 
BRM: 
BPO: 
BPJ: 
BPIP: 
BPW: 
SBR: 
MAR: 
CYN: 
AMR: 
RIV: 
TER: 
 » show all
Taxonomy
Reference
1
  Authors
Borsook, H. and Dubnoff, J.W.
  Title
The formation of glycocyamine in animal tissues.
  Journal
J. Biol. Chem. 138 (1941) 389-403.
Reference
2  [PMID:14304853]
  Authors
CONCONI F, GRAZI E.
  Title
TRANSAMIDINASE OF HOG KIDNEY. I. PURIFICATION AND PROPERTIES.
  Journal
J. Biol. Chem. 240 (1965) 2461-4.
  Organism
Sus scofa [GN:ssc]
Reference
3  [PMID:6766137]
  Authors
McGuire DM, Tormanen CD, Segal IS, Van Pilsum JF.
  Title
The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats. Purification and some properties of rat kidney transamidinase.
  Journal
J. Biol. Chem. 255 (1980) 1152-9.
  Organism
Rattus norvegicus [GN:rno]
Reference
4
  Authors
Ratner, S.
  Title
Transamidination.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 267-275.
Reference
5  [PMID:13355454]
  Authors
RATNER S, ROCHOVANSKY O.
  Title
Biosynthesis of guanidinoacetic acid.  I.  Purification and properties of transamidinase.
  Journal
Arch. Biochem. Biophys. 63 (1956) 277-95.
  Organism
Rattus norvegicus [GN:rno]
Reference
6  [PMID:13355455]
  Authors
RATNER S, ROCHOVANSKY O.
  Title
Biosynthesis of guanidinoacetic acid.  II.  Mechanism of amidine group transfer.
  Journal
Arch. Biochem. Biophys. 63 (1956) 296-315.
  Organism
Sus scofa [GN:ssc]
Reference
7  [PMID:13278360]
  Authors
WALKER JB.
  Title
Biosynthesis of arginine from canavanine and ornithine in kidney.
  Journal
J. Biol. Chem. 218 (1956) 549-56.
  Organism
Sus scofa [GN:ssc]
Reference
8  [PMID:13398387]
  Authors
WALKER JB.
  Title
Studies on the mechanism of action of kidney transamidinase.
  Journal
J. Biol. Chem. 224 (1957) 57-66.
  Organism
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-35-4

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