| Entry |
|
|---|
| Name |
glycine amidinotransferase;
arginine-glycine amidinotransferase;
arginine-glycine transamidinase;
glycine transamidinase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Amidinotransferases
 |
|---|
| Sysname |
L-arginine:glycine amidinotransferase |
|---|
| Reaction(IUBMB) |
L-arginine + glycine = L-ornithine + guanidinoacetate [RN:R00565] |
|---|
| Reaction(KEGG) |
R00565;
(other) R01686 R01989
 |
|---|
| Substrate |
L-arginine [CPD:C00062];
glycine [CPD:C00037] |
|---|
| Product |
L-ornithine [CPD:C00077];
guanidinoacetate [CPD:C00581] |
|---|
| Comment |
Canavanine can act instead of arginine. |
|---|
| Pathway |
PATH: ec00260 Glycine, serine and threonine metabolism
PATH: ec00330 Arginine and proline metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00613 glycine amidinotransferase |
|---|
| Genes |
HSA: 2628(GATM)
PTR: 453401(GATM)
MCC: 713306(GATM)
MMU: 67092(Gatm)
RNO: 81660(Gatm)
CFA: 414733(GATM)
BTA: 414732(GATM)
SSC: 100126844(GATM)
ECB: 100070511
MDO: 100012229
GGA: 395504(GATM)
TGU: 100224553
XLA: 379386(MGC53198)
XTR: 394568
DRE: 266799(gatm)
BFO: BRAFLDRAFT_280917
CIN: 100186832
SPU: 581473
SMM: Smp_144220
NVE: NEMVE_v1g213452
CIM: CIMG_06186
URE: UREG_04197
PLU: plu0158
PAY: PAU_00111
PPR: PBPRA0993
PST: PSPTO_0873
PSP: PSPPH_4303
SHL: Shal_0690
LHK: LHK_03077
PUB: SAR11_0688(gatM)
NWI: Nwi_2321
MNO: Mnod_7150
BID: Bind_1964
JAN: Jann_0016
RDE: RD1_1472(gatM)
PAC: PPA0632
SEN: SACE_4336
AMI: Amir_2021
SAQ: Sare_2924
CCU: Ccur_01930
ELE: Elen_0143
MAR: MAE_21180
CYN: Cyan7425_3009
TER: Tery_3130
AMR: AM1_0523
 |
|---|
| Structures |
PDB: 1JDW 1JDX 2JDW 2JDX 3JDW 4JDW 5JDW 6JDW 7JDW 8JDW
9JDW |
|---|
Reference
Authors
Title
Journal
|
1
Borsook, H. and Dubnoff, J.W.
The formation of glycocyamine in animal tissues.
J. Biol. Chem. 138 (1941) 389-403. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14304853]
CONCONI F, GRAZI E.
TRANSAMIDINASE OF HOG KIDNEY. I. PURIFICATION AND PROPERTIES.
J. Biol. Chem. 240 (1965) 2461-4.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6766137]
McGuire DM, Tormanen CD, Segal IS, Van Pilsum JF.
The effect of growth hormone and thyroxine on the amount of
L-arginine:glycine amidinotransferase in kidneys of
hypophysectomized rats. Purification and some properties of rat
kidney transamidinase.
J. Biol. Chem. 255 (1980) 1152-9.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
|
4
Ratner, S.
Transamidination.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 6, Academic Press, New York, 1962, p. 267-275. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:13355454]
RATNER S, ROCHOVANSKY O.
Biosynthesis of guanidinoacetic acid. I. Purification and
properties of transamidinase.
Arch. Biochem. Biophys. 63 (1956) 277-95.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:13355455]
RATNER S, ROCHOVANSKY O.
Biosynthesis of guanidinoacetic acid. II. Mechanism of amidine
group transfer.
Arch. Biochem. Biophys. 63 (1956) 296-315.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:13278360]
WALKER JB.
Biosynthesis of arginine from canavanine and ornithine in kidney.
J. Biol. Chem. 218 (1956) 549-56.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
8 [PMID:13398387]
WALKER JB.
Studies on the mechanism of action of kidney transamidinase.
J. Biol. Chem. 224 (1957) 57-66.
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.4.1
IUBMB Enzyme Nomenclature: 2.1.4.1
ExPASy - ENZYME nomenclature database: 2.1.4.1
BRENDA, the Enzyme Database: 2.1.4.1
CAS: 9027-35-4 |
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