KEGG   ENZYME: 2.2.1.5Help
Entry
EC 2.2.1.5                  Enzyme                                 
Name
2-hydroxy-3-oxoadipate synthase;
2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating);
alpha-ketoglutaric-glyoxylic carboligase;
oxoglutarate: glyoxylate carboligase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)
Reaction(IUBMB)
2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 [RN:R00474]
Reaction(KEGG)
Substrate
2-oxoglutarate [CPD:C00026];
glyoxylate [CPD:C00048]
Product
2-hydroxy-3-oxoadipate [CPD:C03217];
CO2 [CPD:C00011]
Comment
The bacterial enzyme requires thiamine diphosphate. The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate.
Pathway
Glyoxylate and dicarboxylate metabolism
Reference
1  [PMID:5418712]
  Authors
Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW.
  Title
Carboligase activity of alpha-ketoglutarate dehydrogenase.
  Journal
Biochemistry. 9 (1970) 1148-53.
  Organism
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc]
Reference
2  [PMID:4320439]
  Authors
Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW.
  Title
Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase.
  Journal
Biochemistry. 7 (1968) 333-7.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:16742506]
  Authors
Stewart PR, Quayle JR.
  Title
The synergistic decarboxylation of glyoxylate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria.
  Journal
Biochem. J. 102 (1967) 885-897.
  Organism
Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9054-72-2
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