| Entry |
|
|---|
| Name |
2-hydroxy-3-oxoadipate synthase;
2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating);
alpha-ketoglutaric-glyoxylic carboligase;
oxoglutarate: glyoxylate carboligase |
|---|
| Class |
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
 |
|---|
| Sysname |
2-oxoglutarate:glyoxylate succinaldehydetransferase
(decarboxylating) |
|---|
| Reaction(IUBMB) |
2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2
[RN:R00474] |
|---|
| Reaction(KEGG) |
R00474
 |
|---|
| Substrate |
2-oxoglutarate [CPD:C00026];
glyoxylate [CPD:C00048] |
|---|
| Product |
2-hydroxy-3-oxoadipate [CPD:C03217];
CO2 [CPD:C00011] |
|---|
| Cofactor |
Thiamin diphosphate [CPD:C00068] |
|---|
| Comment |
The bacterial enzyme requires thiamine diphosphate. The product
decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can
decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate. |
|---|
| Pathway |
PATH: ec00630 Glyoxylate and dicarboxylate metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5418712]
Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW.
Carboligase activity of alpha-ketoglutarate dehydrogenase.
Biochemistry. 9 (1970) 1148-53.
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4320439]
Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW.
Isolation and identification of 5-hydroxy-4-ketovaleric acid as a
product of alpha-ketoglutarate: glyoxylate carboligase.
Biochemistry. 7 (1968) 333-7.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:16742506]
Stewart PR, Quayle JR.
The synergistic decarboxylation of glyoxylate and 2-oxoglutarate by
an enzyme system from pig-liver mitochondria.
Biochem. J. 102 (1967) 885-897.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.2.1.5
IUBMB Enzyme Nomenclature: 2.2.1.5
ExPASy - ENZYME nomenclature database: 2.2.1.5
BRENDA, the Enzyme Database: 2.2.1.5
CAS: 9054-72-2 |
|---|
