KEGG   ENZYME: 2.2.1.5Help
Entry
EC 2.2.1.5                  Enzyme                                 

Name 2-hydroxy-3-oxoadipate synthase;
2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating);
alpha-ketoglutaric-glyoxylic carboligase;
oxoglutarate: glyoxylate carboligase
Class Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname 2-oxoglutarate:glyoxylate succinaldehydetransferase
(decarboxylating)
Reaction(IUBMB) 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2
[RN:R00474]
Reaction(KEGG) R00474
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Substrate 2-oxoglutarate [CPD:C00026];
glyoxylate [CPD:C00048]
Product 2-hydroxy-3-oxoadipate [CPD:C03217];
CO2 [CPD:C00011]
Cofactor Thiamin diphosphate [CPD:C00068]
Comment The bacterial enzyme requires thiamine diphosphate. The product
decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can
decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate.
Pathway PATH: ec00630  Glyoxylate and dicarboxylate metabolism
Reference
  Authors
  Title
  Journal
  Organism
1  [PMID:5418712]
Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW.
Carboligase activity of alpha-ketoglutarate dehydrogenase.
Biochemistry. 9 (1970) 1148-53.
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc]
Reference
  Authors
  Title

  Journal
  Organism
2  [PMID:4320439]
Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW.
Isolation and identification of 5-hydroxy-4-ketovaleric acid as a
product of alpha-ketoglutarate: glyoxylate carboligase.
Biochemistry. 7 (1968) 333-7.
Bos taurus [GN:bta]
Reference
  Authors
  Title

  Journal
  Organism
3  [PMID:16742506]
Stewart PR, Quayle JR.
The synergistic decarboxylation of glyoxylate and 2-oxoglutarate by
an enzyme system from pig-liver mitochondria.
Biochem. J. 102 (1967) 885-897.
Sus scofa [GN:ssc]
Other DBs ExplorEnz - The Enzyme Database: 2.2.1.5
IUBMB Enzyme Nomenclature: 2.2.1.5
ExPASy - ENZYME nomenclature database: 2.2.1.5
BRENDA, the Enzyme Database: 2.2.1.5
CAS: 9054-72-2

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