| Entry |
|
|---|
| Name |
arginine N-succinyltransferase;
arginine succinyltransferase;
AstA;
arginine and ornithine N2-succinyltransferase;
AOST;
AST;
succinyl-CoA:L-arginine 2-N-succinyltransferase |
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
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| Sysname |
succinyl-CoA:L-arginine N2-succinyltransferase |
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| Reaction(IUBMB) |
succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine [RN:R00832] |
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| Reaction(KEGG) |
R00832
 |
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| Substrate |
succinyl-CoA [CPD:C00091];
L-arginine [CPD:C00062] |
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| Product |
CoA [CPD:C00010];
N2-succinyl-L-arginine [CPD:C03296] |
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| Comment |
Also acts on L-ornithine. This is the first enzyme in the arginine
succinyltransferase (AST) pathway for the catabolism of arginine
[1]. This pathway converts the carbon skeleton of arginine into
glutamate, with the concomitant production of ammonia and conversion
of succinyl-CoA into succinate and CoA. The five enzymes involved in
this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC
3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81
(succinylornithine transaminase), EC 1.2.1.71
(succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96
(succinylglutamate desuccinylase) [2,6]. |
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| Pathway |
PATH: ec00330 Arginine and proline metabolism |
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| Orthology |
KO: K00673 arginine N-succinyltransferase |
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| Genes |
NVE: NEMVE_v1g224744
ECO: b1747(astA)
ECJ: JW1736(astA)
ECD: ECDH10B_1885(astA)
EBW: BWG_1560(astA)
ECE: Z2779
ECS: ECs2453
ECF: ECH74115_2465(astA)
ETW: ECSP_2315(astA)
ECG: E2348C_1875(astA)
ECC: c2147
ECI: UTI89_C1942(astA)
ECP: ECP_1693
ECV: APECO1_816(astA)
ECW: EcE24377A_1969(astA)
ECX: EcHS_A1830(astA)
ECM: EcSMS35_1444(astA)
ECY: ECSE_1917
ECL: EcolC_1885
ECK: EC55989_1915(astA)
ECQ: ECED1_1949(astA)
ECR: ECIAI1_1808(astA)
ECT: ECIAI39_1307(astA)
ECZ: ECS88_1799(astA)
EUM: ECUMN_2036(astA)
ELF: LF82_0180(astA)
EBL: B21_01704(astA)
EBD: ECBD_1898
EBR: ECB_01716(astA)
EOH: ECO103_1940(astA)
EOI: ECO111_2258(astA)
EOJ: ECO26_2522(astA)
EFE: EFER_1318(astA)
STY: STY1810(astA)
SPT: SPA1540(astA)
SEK: SSPA1431
SPQ: SPAB_02039
SEC: SC1327(astA)
SEH: SeHA_C1431(astA)
SEE: SNSL254_A1416(astA)
SEW: SeSA_A1399(astA)
SEA: SeAg_B1869(astA)
SED: SeD_A2042(astA)
SET: SEN1739(astA)
SES: SARI_01675
STM: STM1304(astA)
YPE: YPO1963(astA)
YPK: y2348
YPM: YP_1708(astA)
YPA: YPA_1345
YPG: YpAngola_A2519(astA)
YPP: YPDSF_1160
YPS: YPTB1960(astA)
YPI: YpsIP31758_2120(astA)
YPY: YPK_2228
YPB: YPTS_2012
YEN: YE2468(astA)
SFL: SF1479
SFX: S1596
SFV: SFV_1473
SSN: SSON_1410
SBO: SBO_1343
SBC: SbBS512_E1994(astA)
SDY: SDY_1530
ETA: ETA_18580(astA)
PLU: plu3109(astA)
PAY: PAU_01498(astA)
ENT: Ent638_1697
ESA: ESA_02156
CTU: Ctu_18170(astA)
KPN: KPN_01222(astA) KPN_01494
KPE: KPK_2967 KPK_3221(astA)
KPU: KP1_2252(astA) KP1_2499
CKO: CKO_01773
SPE: Spro_2843
DDA: Dd703_0485
VCH: VC2617
VCO: VC0395_A2194
VCM: VCM66_2537
VCJ: VCD_001746
VVU: VV1_1314
VVY: VV3053
VPA: VP2796
VHA: VIBHAR_00078
VSP: VS_2860
VEX: VEA_002276
VFI: VF_2283(astA)
VFM: VFMJ11_2395(astA)
VSA: VSAL_I2734(astA)
PPR: PBPRA0290
PAE: PA0896(aruF) PA0897(aruG)
PAU: PA14_52690(aruG) PA14_52700(aruF)
PAP: PSPA7_4618(astA) PSPA7_4619(aruF)
PAG: PLES_44191(aruG) PLES_44201(aruF)
PPU: PP_4479(aruG) PP_4480(aruF)
PPF: Pput_1435 Pput_1436
PPG: PputGB1_3984 PputGB1_3985
PPW: PputW619_3768 PputW619_3769
PST: PSPTO_1833(aruF) PSPTO_1834(aruG)
PSB: Psyr_3563 Psyr_3564
PSP: PSPPH_3519(aruG) PSPPH_3520(aruF)
PFL: PFL_2241 PFL_2242 PFL_3055(astA) PFL_4513 PFL_4514
PFO: Pfl01_2053 Pfl01_2054 Pfl01_4283 Pfl01_4284
PFS: PFLU4755 PFLU4756
PEN: PSEEN3880(aruG) PSEEN3881(aruF)
PMY: Pmen_2909 Pmen_2910
AVN: Avin_34480 Avin_34490
ACI: ACIAD1286(astA)
ACB: A1S_1093 A1S_3131
ABM: ABSDF0356(astA)
ABY: ABAYE0353(astA)
ABC: ACICU_01136 ACICU_03333
ABN: AB57_1174(astA) AB57_3586(astA)
ABB: ABBFA_000378(astA) ABBFA_002454(astA)
SON: SO_0618(astA)
SDN: Sden_1055 Sden_3192
SFR: Sfri_3298
SAZ: Sama_1627 Sama_3010
SBL: Sbal_0572
SBM: Shew185_3753
SBN: Sbal195_3879
SBP: Sbal223_3696
SLO: Shew_0579
SPC: Sputcn32_0646
SSE: Ssed_0810
SPL: Spea_3515
SHE: Shewmr4_0612
SHM: Shewmr7_3418
SHN: Shewana3_0611 Shewana3_3548
SHW: Sputw3181_3528
SHL: Shal_3609
SWD: Swoo_0656
SWP: swp_0748
ILO: IL2317
CPS: CPS_0635(astA)
PHA: PSHAa0195(astA) PSHAb0427
PAT: Patl_0164 Patl_0650
MAQ: Maqu_2890 Maqu_3317 Maqu_3318
AMC: MADE_00498
TTU: TERTU_2359
LPN: lpg1706
LPF: lpl1665(astA)
LPP: lpp1671(astA)
LPC: LPC_1135(astA)
HCH: HCH_01948(aruF) HCH_01949(aruG)
CSA: Csal_2806 Csal_2807
MMW: Mmwyl1_3668 Mmwyl1_3669
AHA: AHA_3179(astA)
ASA: ASA_1135(astA)
KKO: Kkor_0787
CVI: CV_1497(aruF) CV_1498(astA)
LHK: LHK_01916(astA) LHK_01917(aruF)
BMA: BMA0592 BMA0593
BMV: BMASAVP1_A2423 BMASAVP1_A2424
BML: BMA10229_A2867 BMA10229_A2868
BMN: BMA10247_1734 BMA10247_1735
BPS: BPSL2388 BPSL2389
BPM: BURPS1710b_2845(astA) BURPS1710b_2846(astA)
BPL: BURPS1106A_2783 BURPS1106A_2784
BPD: BURPS668_2725 BURPS668_2726
BPR: GBP346_A2905(astA) GBP346_A2906(aruF)
BTE: BTH_I1776 BTH_I1777(astA)
BVI: Bcep1808_1100 Bcep1808_1101
BUR: Bcep18194_A4292 Bcep18194_A4293
BCN: Bcen_0702 Bcen_0703
BCH: Bcen2424_1181 Bcen2424_1182
BCM: Bcenmc03_1158 Bcenmc03_1159
BCJ: BCAL1060 BCAL1061
BAM: Bamb_1062 Bamb_1063
BAC: BamMC406_1062 BamMC406_1063
BMU: Bmul_2122 Bmul_2123
BMJ: BMULJ_01121(astA) BMULJ_01122(astA)
BXE: Bxe_A2921 Bxe_A2922
BPH: Bphy_1785 Bphy_1786
BPY: Bphyt_1559 Bphyt_1560
BGL: bglu_1g10110 bglu_1g10120
BBA: Bd0130(astA)
ADE: Adeh_0178
ACP: A2cp1_0199
AFW: Anae109_0195
ANK: AnaeK_0188
MXA: MXAN_6454
SCL: sce1638(astA)
HOH: Hoch_4839
CCR: CC_0581 CC_1606
CCS: CCNA_00617 CCNA_01678
CAK: Caul_2202
MMR: Mmar10_1857
HNE: HNE_1996(astA)
HBA: Hbal_1557 Hbal_1562
ZMO: ZMO0657
ZMN: Za10_0609
NAR: Saro_0883
SAL: Sala_1940
SWI: Swit_0526 Swit_0528
ELI: ELI_08920
 |
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| Structures |
PDB: 1YLE |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:3144259]
Vander Wauven C, Jann A, Haas D, Leisinger T, Stalon V.
N2-succinylornithine in ornithine catabolism of Pseudomonas
aeruginosa.
Arch. Microbiol. 150 (1988) 400-4.
Pseudomonas aeruginosa [GN:pae] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2865249]
Vander Wauven C, Stalon V.
Occurrence of succinyl derivatives in the catabolism of arginine in
Pseudomonas cepacia.
J. Bacteriol. 164 (1985) 882-6.
Pseudomonas cepacia |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:7523119]
Tricot C, Vander Wauven C, Wattiez R, Falmagne P, Stalon V.
Purification and properties of a succinyltransferase from
Pseudomonas aeruginosa specific for both arginine and ornithine.
Eur. J. Biochem. 224 (1994) 853-61.
Pseudomonas aeruginosa [GN:pae] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:9393691]
Itoh Y.
Cloning and characterization of the aru genes encoding enzymes of
the catabolic arginine succinyltransferase pathway in Pseudomonas
aeruginosa.
J. Bacteriol. 179 (1997) 7280-90.
Pseudomonas aeruginosa [GN:pae] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:9696779]
Schneider BL, Kiupakis AK, Reitzer LJ.
Arginine catabolism and the arginine succinyltransferase pathway in
Escherichia coli.
J. Bacteriol. 180 (1998) 4278-86.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:3534538]
Cunin R, Glansdorff N, Pierard A, Stalon V.
Biosynthesis and metabolism of arginine in bacteria.
Microbiol. Rev. 50 (1986) 314-52.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
|
7
Cunin, R., Glansdorff, N., Pierard, A. and Stalon, V.
Erratum report: Biosynthesis and metabolism of arginine in bacteria.
Microbiol. Rev. 51 (1987) 178. |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.109
IUBMB Enzyme Nomenclature: 2.3.1.109
ExPASy - ENZYME nomenclature database: 2.3.1.109
BRENDA, the Enzyme Database: 2.3.1.109
CAS: 99676-48-9 |
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