KEGG   ENZYME: 2.3.1.135Help
Entry
EC 2.3.1.135                Enzyme                                 

Name
phosphatidylcholine---retinol O-acyltransferase;
lecithin---retinol acyltransferase;
phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase;
lecithin:retinol acyltransferase;
lecithin-retinol acyltransferase;
retinyl ester synthase;
LRAT;
lecithin retinol acyl transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase
Reaction(IUBMB)
phosphatidylcholine + retinol---[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein] [RN:R04514]
Reaction(KEGG)
Substrate
phosphatidylcholine [CPD:C00157];
retinol---[cellular-retinol-binding-protein]
Product
2-acylglycerophosphocholine;
retinyl-ester---[cellular-retinol-binding-protein]
Comment
A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol.
History
EC 2.3.1.135 created 1992, modified 2011
Pathway
Retinol metabolism
Orthology
K00678  
phosphatidylcholine-retinol O-acyltransferase
Genes
HSA: 
9227(LRAT)
PTR: 
471328(LRAT)
PPS: 
100990532(LRAT)
GGO: 
101135395(LRAT)
PON: 
100432491(LRAT)
NLE: 
100579669(LRAT)
MCC: 
698871(LRAT)
MCF: 
102123283(LRAT)
CJC: 
100414604(LRAT)
MMU: 
79235(Lrat)
RNO: 
64047(Lrat)
CGE: 
100769559(Lrat)
NGI: 
103751034(Lrat)
HGL: 
OCU: 
100354707(LRAT)
TUP: 
102476648(LRAT)
CFA: 
482660(LRAT)
AML: 
UMR: 
103658037(LRAT)
FCA: 
101092432(LRAT)
PTG: 
102965792(LRAT)
BTA: 
281285(LRAT)
BOM: 
102264381(LRAT)
PHD: 
102326978(LRAT)
CHX: 
102183532(LRAT)
OAS: 
SSC: 
100513994(LRAT)
CFR: 
102520637(LRAT)
BACU: 
103000637(LRAT)
LVE: 
103091446(LRAT)
ECB: 
100069704(LRAT)
MYB: 
102261540(LRAT)
MYD: 
102758952(LRAT)
PALE: 
102888347(LRAT)
MDO: 
100017333(LRAT)
SHR: 
100931949(LRAT)
OAA: 
100080154(LRAT)
GGA: 
422403(LRAT)
MGP: 
APLA: 
101795343(LRAT)
TGU: 
100224470(LRAT)
FAB: 
101813271(LRAT)
PHI: 
102105659(LRAT)
FPG: 
FCH: 
102048889(LRAT)
CLV: 
102087929(LRAT)
ASN: 
102378402(LRAT)
AMJ: 
PSS: 
102463592(LRAT)
CMY: 
102938217(LRAT)
ACS: 
100552136(lrat)
PBI: 
103061458(LRAT)
XLA: 
443823(lrat)
XTR: 
DRE: 
553239(lrata) 553501(lratb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102361576(LRAT)
CMK: 
103189387(lrat)
 » show all
Taxonomy
Reference
1  [PMID:3410848]
  Authors
MacDonald PN, Ong DE.
  Title
Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine.
  Journal
J. Biol. Chem. 263 (1988) 12478-82.
  Sequence
[rno:64047]
Reference
2  [PMID:2722792]
  Authors
Saari JC, Bredberg DL.
  Title
Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes.
  Journal
J. Biol. Chem. 264 (1989) 8636-40.
  Sequence
[bta:281285]
Reference
3  [PMID:8489497]
  Authors
Saari JC, Bredberg DL, Farrell DF
  Title
Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase.
  Journal
Biochem. J. 291 ( Pt 3) (1993) 697-700.
Reference
4  [PMID:9767084]
  Authors
Mata NL, Tsin AT
  Title
Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes.
  Journal
Biochim. Biophys. Acta. 1394 (1998) 16-22.
Reference
5  [PMID:9920938]
  Authors
Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D
  Title
Molecular and biochemical characterization of lecithin retinol acyltransferase.
  Journal
J. Biol. Chem. 274 (1999) 3834-41.
  Sequence
[bta:281285] [hsa:9227]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
117444-03-8

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