| Entry |
|
|---|
| Name |
salutaridinol 7-O-acetyltransferase |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
acetyl-CoA:salutaridinol 7-O-acetyltransferase |
|---|
| Reaction(IUBMB) |
acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol
[RN:R04723] |
|---|
| Reaction(KEGG) |
R04723
 |
|---|
| Substrate |
acetyl-CoA [CPD:C00024];
salutaridinol [CPD:C05220] |
|---|
| Product |
CoA [CPD:C00010];
7-O-acetylsalutaridinol [CPD:C05322] |
|---|
| Comment |
The enzyme is present in the poppy, Papaver somniferum. At pH 8-9
the product, 7-O-acetylsalutaridinol, spontaneously closes the 4->5
oxide bridge by allylic elimination to form the morphine precursor
thebaine |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K13393 salutaridinol 7-O-acetyltransferase |
|---|
Reference
Authors
Title
Journal
|
1
Lenz, R., Zenk, M.H.
Closure of the oxide bridge in morphine biosynthesis.
Tetrahedron Lett. 35 (1994) 3897-3900. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:8537369]
Lenz R, Zenk MH.
Acetyl coenzyme A:salutaridinol-7-O-acetyltransferase from papaver
somniferum plant cell cultures. The enzyme catalyzing the formation
of thebaine in morphine biosynthesis.
J. Biol. Chem. 270 (1995) 31091-6.
Papaver somniferum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.150
IUBMB Enzyme Nomenclature: 2.3.1.150
ExPASy - ENZYME nomenclature database: 2.3.1.150
BRENDA, the Enzyme Database: 2.3.1.150
CAS: 156859-13-1 |
|---|
