KEGG   ENZYME: 2.3.1.154Help
Entry
EC 2.3.1.154                Enzyme                                 

Name
propionyl-CoA C2-trimethyltridecanoyltransferase;
3-oxopristanoyl-CoA hydrolase;
3-oxopristanoyl-CoA thiolase;
peroxisome sterol carrier protein thiolase;
sterol carrier protein;
oxopristanoyl-CoA thiolase;
peroxisomal 3-oxoacyl coenzyme A thiolase;
SCPx;
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase
Reaction(IUBMB)
4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = CoA + 3-oxopristanoyl-CoA [RN:R05330]
Reaction(KEGG)
Substrate
4,8,12-trimethyltridecanoyl-CoA [CPD:C07296];
propanoyl-CoA [CPD:C00100]
Product
CoA [CPD:C00010];
3-oxopristanoyl-CoA [CPD:C07297]
Comment
The peroxisomal protein sterol carrier protein X (SCPx) combines this thiolase activity with its carrier function, and is involved in branched chain fatty acid beta-oxidation in peroxisomes. It also acts on 3-oxopalmitoyl-CoA as a substrate but differs from EC 2.3.1.16 (acetyl-CoA C-acyltransferase), which has little activity towards the 3-oxoacyl-CoA esters of 2-methyl-branched chain fatty acids such as 3-oxopristanoyl-CoA.
History
EC 2.3.1.154 created 2000
Reference
1  [PMID:8063752]
  Authors
Seedorf U, Brysch P, Engel T, Schrage K, Assmann G.
  Title
Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity.
  Journal
J. Biol. Chem. 269 (1994) 21277-83.
Reference
2  [PMID:9245689]
  Authors
Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U.
  Title
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.
  Journal
Biochem. Biophys. Res. Commun. 236 (1997) 565-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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