| Entry |
|
|---|
| Name |
phospholipid:diacylglycerol acyltransferase;
PDAT |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase |
|---|
| Reaction(IUBMB) |
phospholipid + 1,2-diacyl-sn-glycerol = lysophospholipid +
triacylglycerol [RN:R05333] |
|---|
| Reaction(KEGG) |
R05333
 |
|---|
| Substrate |
phospholipid [CPD:C00865];
1,2-diacyl-sn-glycerol [CPD:C00641] |
|---|
| Product |
lysophospholipid [CPD:C06254];
triacylglycerol [CPD:C00422] |
|---|
| Comment |
This enzyme differs from EC 2.3.1.20, diacylglycerol
O-acyltransferase, by synthesising triacylglycerol using an
acyl-CoA-independent mechanism. The specificity of the enzyme for
the acyl group in the phospholipid varies with species, e.g., the
enzyme from castor bean (Ricinus communis) preferentially
incorporates vernoloyl (12,13-epoxyoctadec-9-enoyl) groups into
triacylglycerol, whereas that from the hawk's beard (Crepis
palaestina) incorporates both ricinoleoyl
(12-hydroxyoctadec-9-enoyl) and vernoloyl groups. The enzyme from
the yeast Saccharomyces cerevisiae specifically transfers acyl
groups from the sn-2 position of the phospholipid to diacylglycerol,
thus forming an sn-1-lysophospholipid. |
|---|
| Pathway |
PATH: ec00561 Glycerolipid metabolism |
|---|
| Orthology |
KO: K00679 phospholipid:diacylglycerol acyltransferase |
|---|
| Genes |
OLU: OSTLU_1469
SCE: YNR008W(LRO1)
AGO: AGOS_AFL179C
KLA: KLLA0F06380g
DHA: DEHA0D10868g
PIC: PICST_72946(LRO1)
CGR: CAGL0I05786g
YLI: YALI0E16797g
SPO: SPBC776.14(plh1)
NCR: NCU02416
ANI: AN4992.2
AFM: AFUA_3G09950
AOR: AO090003000514
ANG: An16g03640
CNE: CNL04710
EHI: EHI_099180
TBR: Tb11.01.4790
TCR: 506757.10 510359.340
LMA: LmjF09.1040
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:10829075]
Dahlqvist A, Stahl U, Lenman M, Banas A, Lee M, Sandager L, Ronne H,
Stymne S.
Phospholipid:diacylglycerol acyltransferase: an enzyme that
catalyzes the acyl-CoA-independent formation of triacylglycerol in
yeast and plants.
Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 6487-92.
Crepis palaestina |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.158
IUBMB Enzyme Nomenclature: 2.3.1.158
ExPASy - ENZYME nomenclature database: 2.3.1.158
BRENDA, the Enzyme Database: 2.3.1.158
CAS: 288587-47-3 |
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