| Entry |
|
|---|
| Name |
taxadien-5alpha-ol O-acetyltransferase;
acetyl coenzyme A:taxa-4(20),11(12)-dien-5alpha-ol O-acetyl
transferase |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase |
|---|
| Reaction(IUBMB) |
acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA +
taxa-4(20),11-dien-5alpha-yl acetate [RN:R06307] |
|---|
| Reaction(KEGG) |
R06307
 |
|---|
| Substrate |
acetyl-CoA [CPD:C00024];
taxa-4(20),11-dien-5alpha-ol |
|---|
| Product |
CoA [CPD:C00010];
taxa-4(20),11-dien-5alpha-yl acetate |
|---|
| Comment |
This is the third enzyme in the biosynthesis of the diterpenoid
antineoplastic drug taxol (paclitaxel), which is widely used in the
treatment of carcinomas, sarcomas and melanomas. |
|---|
| Pathway |
PATH: ec00904 Diterpenoid biosynthesis |
|---|
| Orthology |
KO: K12923 taxadien-5-alpha-ol O-acetyltransferase |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:10190984]
Walker K, Ketchum RE, Hezari M, Gatfield D, Goleniowski M, Barthol
A, Croteau R.
Partial purification and characterization of acetyl coenzyme A:
taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes
the first acylation step of taxol biosynthesis.
Arch. Biochem. Biophys. 364 (1999) 273-9.
Taxus canadensis, Taxus cuspidata |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10666320]
Walker K, Schoendorf A, Croteau R.
Molecular cloning of a taxa-4(20),11(12)-dien-5alpha-ol-O-acetyl
transferase cDNA from Taxus and functional expression in Escherichia
coli.
Arch. Biochem. Biophys. 374 (2000) 371-80.
Taxus canadensis, Taxus cuspidata |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.162
IUBMB Enzyme Nomenclature: 2.3.1.162
ExPASy - ENZYME nomenclature database: 2.3.1.162
BRENDA, the Enzyme Database: 2.3.1.162
CAS: 229032-29-5 |
|---|
