KEGG   ENZYME: 2.3.1.164Help
Entry
EC 2.3.1.164                Enzyme                                 

Name
isopenicillin-N N-acyltransferase;
acyl-coenzyme A:isopenicillin N acyltransferase;
isopenicillin N:acyl-CoA: acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:isopenicillin N N-acyltransferase
Reaction(IUBMB)
phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate [RN:R04868]
Reaction(KEGG)
R04868;
(other) R06361
Show
Substrate
phenylacetyl-CoA [CPD:C00582];
isopenicillin N [CPD:C05557];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
penicillin G [CPD:C05551];
L-2-aminohexanedioate [CPD:C00956]
Comment
Proceeds by a two stage mechanism via 6-aminopenicillanic acid. Different from EC 3.5.1.11, penicillin amidase.
History
EC 2.3.1.164 created 2002
Pathway
Penicillin and cephalosporin biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K10852  
isopenicillin-N N-acyltransferase
Genes
PGU: 
YLI: 
TTT: 
FGR: 
NHE: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_1240174(AO090005000709) AOR_1_924074(AO090038000545)
ANG: 
ANI_1_1226024(An02g08570)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
ZTR: 
SCM: 
KPE: 
KVA: 
KOX: 
KOE: 
DDA: 
PVA: 
PAO: 
ROR: 
MHX: 
PPUU: 
PEN: 
PRE: 
RSO: 
RSL: 
RSE: 
REU: 
BPSE: 
BPK: 
BTE: 
BUR: 
BCN: 
BCH: 
BCM: 
BCJ: 
BAM: 
BAC: 
BMU: 
BMJ: 
BCT: 
BXE: 
BPH: 
BGL: 
BUG: 
BGF: 
BGD: 
BYI: 
BUK: 
BPX: 
BUO: 
BPC: 
BPER: 
BPAR: 
BBM: 
BBH: 
BAV: 
BAV1029(aat)
AXY: 
AXO: 
AXN: 
PUT: 
POL: 
AAA: 
VEI: 
VAP: 
HSE: 
CFU: 
DDN: 
DSA: 
DAS: 
DGG: 
BMX: 
DSF: 
HOH: 
MLO: 
RTR: 
BRA: 
TMO: 
PGV: 
CCB: 
DAE: 
AWO: 
NTH: 
MSM: 
MSG: 
RHA: 
ROP: 
SGR: 
SBH: 
SVE: 
SRC: 
AAU: 
ARR: 
PBO: 
NAL: 
FRA: 
FSY: 
SEN: 
SAQ: 
CAI: 
SNA: 
CWO: 
TPI: 
SUS: 
ACO: 
TLI: 
CYB: 
HAO: 
BVU: 
BACC: 
AFD: 
CPI: 
HHY: 
CHU: 
DFE: 
LBY: 
GFO: 
FJO: 
FPS: 
FCO: 
COC: 
ZPR: 
CAT: 
WVI: 
LAN: 
ZGA: 
ASL: 
FTE: 
OHO: 
CAU: 
CAG: 
CHL: 
HAU: 
TRO: 
STI: 
CAP: 
DMR: 
TRA: 
MRB: 
MRE: 
MSV: 
MHD: 
MPZ: 
CCZ: 
DTH: 
DTU: 
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:2120195]
  Authors
Tobin MB, Fleming MD, Skatrud PL, Miller JR.
  Title
Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli.
  Journal
J. Bacteriol. 172 (1990) 5908-14.
  Organism
Aspergillus nidulans, Penicillium chrysogenum
  Sequence
[ani:AN2623.2] [pcs:Pc21g21370]
Reference
2  [PMID:8396910]
  Authors
Aplin RT, Baldwin JE, Roach PL, Robinson CV, Schofield CJ.
  Title
Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
  Journal
Biochem. J. 294 ( Pt 2) (1993) 357-63.
  Organism
Penicillium chrysogenum
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
54576-90-8

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