KEGG   ENZYME: 2.3.1.166Help
Entry
EC 2.3.1.166                Enzyme                                 

Name
2alpha-hydroxytaxane 2-O-benzoyltransferase;
benzoyl-CoA:taxane 2alpha-O-benzoyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase
Reaction(IUBMB)
benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III [RN:R06310]
Reaction(KEGG)
Substrate
benzoyl-CoA [CPD:C00512];
10-deacetyl-2-debenzoylbaccatin III [CPD:C11899]
Product
CoA [CPD:C00010];
10-deacetylbaccatin III [CPD:C11700]
Comment
The enzyme was studied using the semisynthetic substrate 2-debenzoyl-7,13-diacetylbaccatin III. It will not acylate the hydroxy group at 1beta, 7beta, 10beta or 13alpha of 10-deacetyl baccatin III, or at 2alpha or 5alpha of taxa-4(20),11-diene-2alpha,5alpha-diol.
History
EC 2.3.1.166 created 2002
Pathway
Diterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K12925  
2-alpha-hydroxytaxane 2-O-benzoyltransferase
Reference
1  [PMID:11095755]
  Authors
Walker K, Croteau R.
  Title
Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 13591-6.
  Organism
Taxus cuspidata
  Sequence
[up:Q9FPW3]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
329318-50-5

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