| Entry |
|
|---|
| Name |
2alpha-hydroxytaxane 2-O-benzoyltransferase;
benzoyl-CoA:taxane 2alpha-O-benzoyltransferase |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase |
|---|
| Reaction(IUBMB) |
benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA +
10-deacetylbaccatin III [RN:R06310] |
|---|
| Reaction(KEGG) |
R06310
 |
|---|
| Substrate |
benzoyl-CoA [CPD:C00512];
10-deacetyl-2-debenzoylbaccatin III [CPD:C11899] |
|---|
| Product |
CoA [CPD:C00010];
10-deacetylbaccatin III [CPD:C11700] |
|---|
| Comment |
The enzyme was studied using the semisynthetic substrate
2-debenzoyl-7,13-diacetylbaccatin III. It will not acylate the
hydroxy group at 1beta, 7beta, 10beta or 13alpha of 10-deacetyl
baccatin III, or at 2alpha or 5alpha of
taxa-4(20),11-diene-2alpha,5alpha-diol. |
|---|
| Pathway |
PATH: ec00904 Diterpenoid biosynthesis
PATH: ec01062 Biosynthesis of terpenoids and steroids
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K12925 2-alpha-hydroxytaxane 2-O-benzoyltransferase |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11095755]
Walker K, Croteau R.
Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane
2alpha-O-benzoyltransferase cDNA from taxus and functional
expression in Escherichia coli.
Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 13591-6.
Taxus cuspidata |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.166
IUBMB Enzyme Nomenclature: 2.3.1.166
ExPASy - ENZYME nomenclature database: 2.3.1.166
BRENDA, the Enzyme Database: 2.3.1.166
CAS: 329318-50-5 |
|---|
