KEGG   ENZYME: 2.3.1.169Help
Entry
EC 2.3.1.169                Enzyme                                 

Name
CO-methylating acetyl-CoA synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:corrinoid protein O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + corrinoid protein = CoA + CO + methylcorrinoid protein [RN:R08433]
Reaction(KEGG)
R08433;
(other) R09317 R10243
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Substrate
acetyl-CoA [CPD:C00024];
corrinoid protein [CPD:C06021]
Product
CoA [CPD:C00010];
CO [CPD:C00237];
methylcorrinoid protein [CPD:C06020]
Comment
Contains nickel, copper and iron-sulfur clusters. Also catalyses exchange reactions of carbon between C-1 of acetyl-CoA and CO, and between C-2 of acetyl-CoA and methyl corrinoid protein. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2. To follow its stoichiometry, the reaction can be written as: CH3-CO-S-CoA + protein Co+ + H+ = CO + protein Co2+-CH3 + HS-CoA.
History
EC 2.3.1.169 created 2003
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14138  
acetyl-CoA synthase
Genes
DAK: 
DSF: 
DOL: 
DAL: 
DAT: 
DTO: 
DAO: 
DTI: 
SFU: 
DBR: 
CLJ: 
CAH: 
AMT: 
CDF: 
CDC: 
CDL: 
CDG: 
CST: 
DSY: 
DHD: 
DDH: 
DDL: 
DAE: 
DKU: 
DGI: 
DAU: 
TJR: 
DOR: 
DAI: 
DMI: 
DED: 
DEC: 
DRS: 
ELM: 
AWO: 
Awo_c10760(acsB1) Awo_c33680(acsB2)
TKI: 
CHY: 
CHY_1222(acsB)
TEP: 
TAE: 
MTA: 
ADG: 
TPZ: 
TOC: 
AAR: 
TAZ: 
TPI: 
DET: 
DEH: 
cbdb_A652(codH)
DEB: 
DEV: 
DhcVS_604(cdhC)
DEG: 
DMC: 
btf_622(acsB)
DMD: 
dcmb_668(acsB)
DMG: 
GY50_0591(cdhC)
DLY: 
TYE: 
TID: 
TOP: 
TCM: 
MER: 
 » show all
Taxonomy
Reference
1  [PMID:2984190]
  Authors
Ragsdale SW, Wood HG.
  Title
Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.
  Journal
J. Biol. Chem. 260 (1985) 3970-7.
Reference
2  [PMID:12386327]
  Authors
Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL.
  Title
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
  Journal
Science. 298 (2002) 567-72.
  Sequence
[mta:Moth_1202]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
176591-19-8

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