KEGG   ENZYME: 2.3.1.177Help
Entry
EC 2.3.1.177                Enzyme                                 

Name
3,5-dihydroxybiphenyl synthase;
BIS1;
biphenyl synthase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:benzoyl-CoA malonyltransferase
Reaction(IUBMB)
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 [RN:R09621]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
benzoyl-CoA [CPD:C00512]
Product
CoA [CPD:C00010];
3,5-dihydroxybiphenyl [CPD:C19750];
CO2 [CPD:C00011]
Comment
A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208, 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC 2.3.1.151, benzophenone synthase.
History
EC 2.3.1.177 created 2006, modified 2012
Reference
1  [PMID:14595561]
  Authors
Liu B, Beuerle T, Klundt T, Beerhues L.
  Title
Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia.
  Journal
Planta. 218 (2004) 492-6.
  Organism
Sorbus aucuparia
  Sequence
[up:Q27Z07]
Reference
2  [PMID:17109150]
  Authors
Liu B, Raeth T, Beuerle T, Beerhues L
  Title
Biphenyl synthase, a novel type III polyketide synthase.
  Journal
Planta. 225 (2007) 1495-503.
  Organism
Sorbus aucuparia
  Sequence
[up:Q27Z07]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
1217551-24-0

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