| Entry |
|
|---|
| Name |
diacylglycerol O-acyltransferase;
diglyceride acyltransferase;
1,2-diacylglycerol acyltransferase;
diacylglycerol acyltransferase;
diglyceride O-acyltransferase;
palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase;
acyl-CoA:1,2-diacylglycerol O-acyltransferase |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase |
|---|
| Reaction(IUBMB) |
acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + triacylglycerol
[RN:R02251] |
|---|
| Reaction(KEGG) |
R02251 > R02694
 |
|---|
| Substrate |
acyl-CoA [CPD:C00040];
1,2-diacyl-sn-glycerol [CPD:C00641] |
|---|
| Product |
CoA [CPD:C00010];
triacylglycerol [CPD:C00422] |
|---|
| Comment |
Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. |
|---|
| Pathway |
PATH: ec00561 Glycerolipid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00635 diacylglycerol O-acyltransferase
KO: K11155 diacylglycerol O-acyltransferase 1
KO: K11160 diacylglycerol O-acyltransferase 2 |
|---|
| Genes |
HSA: 84649(DGAT2) 8694(DGAT1)
PTR: 464460(DGAT1) 466714(DGAT2)
MCC: 701489(DGAT1)
MMU: 13350(Dgat1) 67800(Dgat2)
RNO: 252900(Dgat2) 84497(Dgat1)
CFA: 482093(DGAT1) 485185(DGAT2)
BTA: 282609(DGAT1) 404129(DGAT2)
SSC: 397118(DGAT)
ECB: 100064387 100147359
MDO: 100011089 100018271
OAA: 100088895
GGA: 421309(DGAT2)
TGU: 100220095
XLA: 398800
XTR: 395003(dgat2)
DRE: 325875(dgat1) 565316(dgat2)
SPU: 575003
DME: Dmel_CG31991(mdy)
DPO: Dpse_GA16599
AGA: AgaP_AGAP007843
AAG: AaeL_AAEL001204
TCA: 664028
CEL: H19N07.4
CBR: CBG23107
BMY: Bm1_52020
NVE: NEMVE_v1g239390
TAD: TRIADDRAFT_35841
OSA: 4341317(Os06g0563900)
YLI: YALI0D07986g
MGR: MGG_05326
ANI: AN6159.2
AFM: AFUA_2G08380
AOR: AO090011000863
ANG: An12g03600
MBR: MONBRDRAFT_20830
DDI: DDBDRAFT_0202877
PFA: MAL3P7.29
PYO: PY01256
TAN: TA19620
CPV: cgd2_1090
CHO: Chro.20121
TET: TTHERM_00971690
PAR: Psyc_0223
ACI: ACIAD0832(wax-dgaT)
ACB: A1S_2776
ABM: ABSDF0686(wax-dgaT)
ABY: ABAYE0708(wax-dgaT)
ABO: ABO_1804(atfA2) ABO_2742(atfA1)
ADE: Adeh_2067
MMC: Mmcs_0203 Mmcs_0793 Mmcs_0858 Mmcs_1355 Mmcs_2545 Mmcs_3331
Mmcs_3408 Mmcs_3409 Mmcs_3541 Mmcs_3620 Mmcs_3757 Mmcs_4258
Mmcs_4504 Mmcs_5082
MJL: Mjls_0192 Mjls_0788 Mjls_0864 Mjls_1389 Mjls_2583 Mjls_3342
Mjls_3419 Mjls_3420 Mjls_3546 Mjls_3625 Mjls_3769 Mjls_4125
Mjls_4637 Mjls_4887 Mjls_5461
NCA: Noca_1218 Noca_1396 Noca_1669 Noca_2792 Noca_3706
FRA: Francci3_1982 Francci3_2484
SUS: Acid_1785
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:947894]
Coleman R, Bell RM.
Triacylglycerol synthesis in isolated fat cells. Studies on the
microsomal diacylglycerol acyltransferase activity using
ethanol-dispersed diacylglycerols.
J. Biol. Chem. 251 (1976) 4537-43.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6289909]
Grigor MR, Bell RM.
Separate monoacylglycerol and diacylglycerol acyltransferases
function in intestinal triacylglycerol synthesis.
Biochim. Biophys. Acta. 712 (1982) 464-72.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:3422635]
Kawasaki T, Snyder F.
Synthesis of a novel acetylated neutral lipid related to
platelet-activating factor by
acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60
cells.
J. Biol. Chem. 263 (1988) 2593-6.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13843753]
WEISS SB, KENNEDY EP, KIYASU JY.
The enzymatic synthesis of triglycerides.
J. Biol. Chem. 235 (1960) 40-4.
Gallus gallus [GN:gga] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.20
IUBMB Enzyme Nomenclature: 2.3.1.20
ExPASy - ENZYME nomenclature database: 2.3.1.20
BRENDA, the Enzyme Database: 2.3.1.20
CAS: 9029-98-5 |
|---|
