KEGG   ENZYME: 2.3.1.20Help
Entry
EC 2.3.1.20                 Enzyme                                 

Name
diacylglycerol O-acyltransferase;
diglyceride acyltransferase;
1,2-diacylglycerol acyltransferase;
diacylglycerol acyltransferase;
diglyceride O-acyltransferase;
palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase;
acyl-CoA:1,2-diacylglycerol O-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + triacylglycerol [RN:R02251]
Reaction(KEGG)
R02251 > R02694;
(other) R09474
Show
Substrate
acyl-CoA [CPD:C00040];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CoA [CPD:C00010];
triacylglycerol [CPD:C00422]
Comment
Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
History
EC 2.3.1.20 created 1965
Pathway
Cutin, suberine and wax biosynthesis
Glycerolipid metabolism
Metabolic pathways
Orthology
K00635  
diacylglycerol O-acyltransferase
K11155  
diacylglycerol O-acyltransferase 1
K11160  
diacylglycerol O-acyltransferase 2
K14456  
2-acylglycerol O-acyltransferase 3
K15406  
wax-ester synthase / diacylglycerol O-acyltransferase
Genes
HSA: 
346606(MOGAT3) 84649(DGAT2) 8694(DGAT1)
PTR: 
464460(DGAT1) 466714(DGAT2) 472468(MOGAT3)
PPS: 
100969446(MOGAT3) 100987880(DGAT2) 100994391(DGAT1)
GGO: 
101124779(DGAT2) 101142898(DGAT1) 101150469(MOGAT3)
PON: 
100439588(MOGAT3) 100442216(DGAT2) 100453587(DGAT1)
NLE: 
MCC: 
MCF: 
102116598(MOGAT3) 102121566(DGAT1) 102128601(DGAT2)
CJC: 
100402659(DGAT1) 100414192(DGAT2) 100415057(MOGAT3)
MMU: 
13350(Dgat1) 67800(Dgat2)
RNO: 
252900(Dgat2) 84497(Dgat1)
CGE: 
100755985(Dgat1) 100769277(Mogat3) 100774981(Dgat2)
NGI: 
103733547(Mogat3) 103735255(Dgat1) 103743019(Dgat2)
HGL: 
101698712(Dgat2) 101723650(Dgat1)
OCU: 
TUP: 
102471587(MOGAT3) 102474487(DGAT1) 102494423(DGAT2)
CFA: 
482093(DGAT1) 485185(DGAT2) 608245(MOGAT3)
AML: 
UMR: 
103656696(DGAT1) 103670128(MOGAT3) 103678126(DGAT2)
FCA: 
101089413(MOGAT3) 101100329(DGAT2) 101101615(DGAT1)
PTG: 
102952153(DGAT2) 102952284(DGAT1) 102971732(MOGAT3)
BTA: 
282609(DGAT1) 404129(DGAT2) 618076(MOGAT3)
BOM: 
PHD: 
CHX: 
100861225(DGAT1) 102170308(MOGAT3) 102174409(DGAT2)
OAS: 
SSC: 
100294675(DGAT2) 100624333(MOGAT3) 397118(DGAT)
CFR: 
102504113(DGAT2) 102515256(DGAT1) 102519554(MOGAT3)
BACU: 
103001320(DGAT1) 103018277(DGAT2) 103018879(MOGAT3)
LVE: 
103073062(DGAT1) 103075069(DGAT2)
ECB: 
100060232(MOGAT3) 100064387(DGAT2) 100147359(DGAT1)
MYB: 
102249216 102249575(MOGAT3) 102261774(DGAT2) 102263903(DGAT1)
MYD: 
102753473(DGAT2) 102755787(MOGAT3) 102769363(DGAT1)
PALE: 
102881221(MOGAT3) 102889573(DGAT1) 102898739(DGAT2)
MDO: 
100011089(DGAT2) 100017805(MOGAT3) 100018271(DGAT1)
SHR: 
OAA: 
100088895(DGAT2) 100089507(MOGAT3) 103166832(DGAT1)
GGA: 
421309(DGAT2) 428693
APLA: 
101801215(DGAT2)
TGU: 
100220095(DGAT2)
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
103052621(DGAT2) 103065772(DGAT1)
XLA: 
398800(dgat2)
XTR: 
100127752(dgat2l6) 101730812(dgat1) 395003(dgat2)
DRE: 
325875(dgat1a) 565316(dgat2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
552377(mdy)
NVI: 
TCA: 
BMOR: 
PHU: 
ISC: 
CEL: 
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT2G19450(TAG1) AT5G37300(WSD1)
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
547982(DGAT) 548005(DAGAT1) 732606(DGAT1b)
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os05t0196800-00(Os05g0196800) Os06t0563900-01(Os06g0563900)
OBR: 
BDI: 
SBI: 
SORBI_09g006110(SORBIDRAFT_09g006110) SORBI_10g022270(SORBIDRAFT_10g022270)
ZMA: 
SITA: 
PDA: 
MUS: 
ATR: 
s00036p00158260(AMTR_s00036p00158260)
SMO: 
PPP: 
VCN: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
YLI: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1456054(AO090011000863)
ANG: 
ANI_1_1688104(An12g03600)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
ECU: 
EIN: 
EHE: 
NCE: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
PFA: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
TAN: 
TPV: 
BBO: 
BBOV_IV004970(23.m06462)
CPV: 
CHO: 
TGO: 
TET: 
PTI: 
TPS: 
EHX: 
GTT: 
NGR: 
PAR: 
ACI: 
ACIAD0832(wax-dgaT)
ACB: 
ABM: 
ABSDF0686(wax-dgaT)
ABY: 
ABAYE0708(wax-dgaT)
ABO: 
ABO_1804(atfA2) ABO_2742(atfA1)
ADE: 
MMC: 
MJL: 
NCA: 
FRA: 
SUS: 
 » show all
Taxonomy
Reference
1  [PMID:947894]
  Authors
Coleman R, Bell RM.
  Title
Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols.
  Journal
J. Biol. Chem. 251 (1976) 4537-43.
Reference
2  [PMID:6289909]
  Authors
Grigor MR, Bell RM.
  Title
Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis.
  Journal
Biochim. Biophys. Acta. 712 (1982) 464-72.
Reference
3  [PMID:3422635]
  Authors
Kawasaki T, Snyder F.
  Title
Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells.
  Journal
J. Biol. Chem. 263 (1988) 2593-6.
Reference
4  [PMID:13843753]
  Authors
WEISS SB, KENNEDY EP, KIYASU JY.
  Title
The enzymatic synthesis of triglycerides.
  Journal
J. Biol. Chem. 235 (1960) 40-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-98-5

DBGET integrated database retrieval system