KEGG   ENZYME: 2.3.1.21Help
Entry
EC 2.3.1.21                 Enzyme                                 

Name
carnitine O-palmitoyltransferase;
CPT;
CPTo;
outer malonyl-CoA inhibitable carnitine palmitoyltransferase;
CPTi;
CPT I (outer membrane carnitine palmitoyl transferase);
carnitine palmitoyltransferase I;
carnitine palmitoyltransferase II;
CPT-A;
CPT-B;
acylcarnitine transferase;
carnitine palmitoyltransferase;
carnitine palmitoyltransferase-A;
L-carnitine palmitoyltransferase;
palmitoylcarnitine transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
palmitoyl-CoA:L-carnitine O-palmitoyltransferase
Reaction(IUBMB)
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine [RN:R01923]
Reaction(KEGG)
Substrate
palmitoyl-CoA [CPD:C00154];
L-carnitine [CPD:C00318]
Product
CoA [CPD:C00010];
L-palmitoylcarnitine [CPD:C02990]
Comment
Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase.
History
EC 2.3.1.21 created 1972
Pathway
Fatty acid degradation
Orthology
K08765  
carnitine O-palmitoyltransferase 1
K08766  
carnitine O-palmitoyltransferase 2
Genes
HSA: 
126129(CPT1C) 1374(CPT1A) 1375(CPT1B) 1376(CPT2)
PTR: 
451382(CPT1A) 470253(CPT1B) 737945(CPT2) 748258(CPT1C)
PPS: 
100969017(CPT1A) 100977928(CPT1B) 100978250(CPT1C) 100983874(CPT2)
GGO: 
101128037(CPT1A) 101141306(CPT1B) 101147238(CPT1C) 101147523(CPT2)
PON: 
100172407(CPT1C) 100442465(CPT2) 100444942(CPT1B) 100448104(CPT1A)
MCC: 
709837(CPT1A) 714150(CPT2) 720697(CPT1B)
MCF: 
MMU: 
12894(Cpt1a) 12895(Cpt1b) 12896(Cpt2) 78070(Cpt1c)
RNO: 
25413(Cpt2) 25756(Cpt1b) 25757(Cpt1a) 308579(Cpt1c)
CGE: 
100762166(Cpt1a) 100766757(Cpt2) 100767138(Cpt1c) 100770034(Cpt1b)
HGL: 
101709766(Cpt2) 101716055(Cpt1a) 101719936(Cpt1c) 101724285(Cpt1b)
TUP: 
102481324(CPT1B) 102485726(CPT2) 102486942(CPT1C) 102493851(CPT1A)
CFA: 
100856778(CPT1C) 403583(CPT1A) 481184(CPT1B) 489585(CPT2)
AML: 
FCA: 
101083187(CPT1B) 101093287(CPT2) 101095144(CPT1C) 101096105(CPT1A)
PTG: 
102948684(CPT2) 102952682(CPT1B) 102960681(CPT1A) 102969205(CPT1C)
BTA: 
504502(CPT2) 506812(CPT1A) 509459(CPT1B) 513710(CPT1C)
BOM: 
102265568(CPT1A) 102269192(CPT1B) 102281690(CPT2) 102287746(CPT1C)
PHD: 
102321116(CPT2) 102328573(CPT1A) 102336252(CPT1C) 102343440(CPT1B)
CHX: 
102173497(CPT1C) 102180988(CPT2) 102187210(CPT1B) 102187923(CPT1A)
OAS: 
101113171(CPT1C) 101118317(CPT2) 443193(CPT1B) 443434(CPT1A)
SSC: 
100519258(CPT1C) 100519491(CPT2) 399527(CPT1A) 399528(CPT1B)
CFR: 
102505825(CPT1C) 102517968(CPT1A) 102519937(CPT2) 102524549(CPT1B)
BACU: 
103003703(CPT1C) 103007290(CPT2) 103011201(CPT1A) 103015428(CPT1B)
LVE: 
103068754(CPT1A) 103073152(CPT1C) 103073664(CPT1B) 103082924(CPT2)
ECB: 
100009716(CPT1A) 100055438(CPT1B) 100056027(CPT1C) 100061061(CPT2)
MYB: 
102242927(CPT1C) 102243793(CPT2) 102252400(CPT1B) 102261269(CPT1A)
MYD: 
102759504(CPT1A) 102764960(CPT1B) 102766661(CPT2) 102770000(CPT1C)
PALE: 
102878033(CPT1C) 102879520(CPT1B) 102886073(CPT1A) 102886099(CPT2)
MDO: 
100012188(CPT1B) 100012915(CPT1A) 100017404(CPT2)
SHR: 
OAA: 
GGA: 
423118(CPT1A) 424649(CPT2)
MGP: 
TGU: 
100222209(CPT2) 100226785(CPT1A)
FAB: 
101819946(CPT1A) 101821336(CPT2)
PHI: 
APLA: 
101799612(CPT1A) 101804289(CPT2)
FPG: 
101915684(CPT1A) 101916323(CPT1B) 101916680(CPT2)
FCH: 
102046436(CPT2) 102056621(CPT1A) 102058618(CPT1B)
CLV: 
102085732(CPT2) 102089943(CPT1A) 102094115(CPT1B)
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379393(cpt1a) 379893(cpt2) 495682(cpt1b)
XTR: 
100135089(cpt1a) 100490391 394801(cpt2) 780223(cpt1b)
DRE: 
100005717(cpt2) 558088(cpt1a) 560000(fc31g06)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
411473(GB17924) 550695(CPTI)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG06027(Cbr-cpt-2) CBG07886(Cbr-cpt-1)
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
100206022(cpt1a) 100214547(cpt2)
TAD: 
AQU: 
MBR: 
PIF: 
EHX: 
GTT: 
TBR: 
Tb927.7.2250(Tb07.22O10.200)
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
MMI: 
MLI: 
 » show all
Taxonomy
Reference
1
  Authors
Derrick, J.P., Tubbs, P.K. and Ramsay, R.R.
  Title
Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef-liver mitochondria.
  Journal
Biochem. Soc. Trans. 14 (1986) 698.
Reference
2  [PMID:3342008]
  Authors
Healy MJ, Kerner J, Bieber LL.
  Title
Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?
  Journal
Biochem. J. 249 (1988) 231-7.
  Organism
Rattus norvegicus
Reference
3  [PMID:6630173]
  Authors
Miyazawa S, Ozasa H, Osumi T, Hashimoto T.
  Title
Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver.
  Journal
J. Biochem. (Tokyo). 94 (1983) 529-42.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9068-41-1

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