KEGG   ENZYME: 2.3.1.23Help
Entry
EC 2.3.1.23                 Enzyme                                 
Name
1-acylglycerophosphocholine O-acyltransferase;
lysolecithin acyltransferase;
1-acyl-sn-glycero-3-phosphocholine acyltransferase;
acyl coenzyme A-monoacylphosphatidylcholine acyltransferase;
acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase;
lysophosphatide acyltransferase;
lysophosphatidylcholine acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine [RN:R01318]
Reaction(KEGG)
R01318;
(other) R03438 R04480
Show
Substrate
acyl-CoA [CPD:C00040];
1-acyl-sn-glycero-3-phosphocholine [CPD:C04230]
Product
CoA [CPD:C00010];
1,2-diacyl-sn-glycero-3-phosphocholine [CPD:C00157]
Comment
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
Pathway
Glycerophospholipid metabolism
Orthology
K13510  
lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase
K13512  
lysophospholipid acyltransferase
K13515  
lysophospholipid acyltransferase 5
K13519  
lysophospholipid acyltransferase
Genes
HSA: 
10162(LPCAT3) 254531(LPCAT4) 54947(LPCAT2) 79888(LPCAT1)
PTR: 
451807(LPCAT3) 453302(LPCAT4) 454095(LPCAT2) 461698(LPCAT1)
PPS: 
100970278(LPCAT2) 100991640(LPCAT3) 100991866(LPCAT1) 100994535(LPCAT4)
GGO: 
101124582 101138654(LPCAT3) 101146143(LPCAT4) 101148534(LPCAT2)
PON: 
100435855(LPCAT1) 100438914(LPCAT4) 100449193(LPCAT3) 100449928(LPCAT2)
MCC: 
696388(LPCAT4) 698605(LPCAT2) 710144(LPCAT1) 714639(LPCAT3)
MMU: 
14792(Lpcat3) 210992(Lpcat1) 270084(Lpcat2) 99010(Lpcat4)
RNO: 
100359680(Lpcat2) 296048(Lpcat4) 361467(Lpcat1) 362434(Lpcat3)
CFA: 
478238(LPCAT4) 486715(LPCAT3) 488066(LPCAT1) 611330(LPCAT2)
AML: 
100464874(LPCAT2) 100471481(LPCAT4) 100472770(LPCAT3) 100480167
FCA: 
101088419(LPCAT3) 101090943(LPCAT4) 101095078(LPCAT1) 101099093(LPCAT2)
BTA: 
510842(LPCAT4) 514646(LPCAT2) 515361(LPCAT3) 788450(LPCAT1)
SSC: 
100152542(LPCAT4) 100217397(LPCAT1) 100517894(LPCAT2) 100627653(LPCAT3)
ECB: 
100053035(LPCAT3) 100061308(LPCAT2) 100071891(LPCAT4) 100071898
MDO: 
100014768(LPCAT2) 100015539 100016730(LPCAT3) 100031531(LPCAT4)
SHR: 
100915216(LPCAT1) 100919196(LPCAT4) 100924769(LPCAT3) 100935270(LPCAT2)
OAA: 
100074850 100077162(LPCAT2) 100083365 100084970
GGA: 
415716(LPCAT2) 418293(LPCAT3) 420974(LPCAT1)
MGP: 
100541281 100546916 100547104
TGU: 
100218938(LPCAT2) 100224379(LPCAT1) 100225934 100231699
ACS: 
100557762(lpcat2) 100560524(lpcat3) 100563014 100564138
XLA: 
446240(lpcat4) 447297(lpcat3-a)
XTR: 
100124943(lpcat2) 100487143 100498491(lpcat3) 548367(lpcat4)
DRE: 
327566(lpcat4) 553683(lpcat2) 555566(lpcat3) 555969(lpcat1)
TRU: 
101067621 101069240 101074488 101078533
OLA: 
101154975 101159130 101161012 101172965
BFO: 
BRAFLDRAFT_222039 BRAFLDRAFT_80751
CIN: 
100181981 100186495
SPU: 
579107 580778 593457
DME: 
Dmel_CG32699 Dmel_CG9655(nes)
DPO: 
Dpse_GA21944 Dpse_GA23062 Dpse_GA25467
DAN: 
Dana_GF10775 Dana_GF22630
DER: 
Dere_GG13418 Dere_GG18969
DPE: 
Dper_GL13112 Dper_GL20914 Dper_GL25842
DSE: 
Dsec_GM11357 Dsec_GM14886
DSI: 
Dsim_GD12294 Dsim_GD16057
DWI: 
Dwil_GK10139 Dwil_GK19695
DYA: 
Dyak_GE15443 Dyak_GE22515 Dyak_GE22919
DGR: 
Dgri_GH12406 Dgri_GH14422
DMO: 
Dmoj_GI13549 Dmoj_GI15857
DVI: 
Dvir_GJ11908 Dvir_GJ19019
AGA: 
AgaP_AGAP000596 AgaP_AGAP012258
AAG: 
AaeL_AAEL001448 AaeL_AAEL005583
CQU: 
CpipJ_CPIJ005745 CpipJ_CPIJ010179
AME: 
550970 724443(nes)
NVI: 
100120270(NV17021) 100121021(nes)
TCA: 
657636 661890
PHU: 
Phum_PHUM293230 Phum_PHUM575140
ISC: 
IscW_ISCW005220
CEL: 
CELE_R155.1(mboa-6)
CBR: 
CBG11740
BMY: 
Bm1_43565
TSP: 
Tsp_09580
SMM: 
Smp_132850.1 Smp_169040
NVE: 
NEMVE_v1g160653
HMG: 
100202190 100203846
TAD: 
TRIADDRAFT_57453 TRIADDRAFT_63570
ATH: 
AT1G12640 AT1G63050 AT1G80950 AT2G45670
ALY: 
ARALYDRAFT_477149 ARALYDRAFT_483703 ARALYDRAFT_888597 ARALYDRAFT_893164
GMX: 
100775331 100778962 100790429 100818109 100820536
MTR: 
MTR_7g104580
CSV: 
101209255 101209553 101218421 101223404 101229079
RCU: 
RCOM_1593790 RCOM_1612980 RCOM_1684130
POP: 
POPTR_1098087 POPTR_551926 POPTR_591825 POPTR_799918 POPTR_815112 POPTR_851914
VVI: 
100251254 100262557 100267860
OSA: 
4330302 4338527 4342043
DOSA: 
Os02t0676000-01(Os02g0676000) Os05t0357800-01(Os05g0357800) Os06t0712300-01(Os06g0712300)
BDI: 
100832624 100834306 100836765 100844469
SBI: 
SORBI_03g012600(SORBIDRAFT_03g012600) SORBI_04g031990(SORBIDRAFT_04g031990) SORBI_10g029780(SORBIDRAFT_10g029780)
ZMA: 
100191712(TIDP3349) 100193648(cl15598_1c) 100284702
SMO: 
SELMODRAFT_121336 SELMODRAFT_123670 SELMODRAFT_150199 SELMODRAFT_184257 SELMODRAFT_420881 SELMODRAFT_65256
PPP: 
PHYPADRAFT_108531 PHYPADRAFT_163873 PHYPADRAFT_173988 PHYPADRAFT_201778 PHYPADRAFT_213782 PHYPADRAFT_43926 PHYPADRAFT_57325
CRE: 
CHLREDRAFT_189038
VCN: 
VOLCADRAFT_120919 VOLCADRAFT_73089 VOLCADRAFT_91941
OLU: 
OSTLU_28292
OTA: 
Ot18g00950
CME: 
CMI139C CMS008C
SCE: 
YOR175C(ALE1)
AGO: 
AGOS_AGR271C
ERC: 
Ecym_3123
KLA: 
KLLA0F20163g
LTH: 
KLTH0G15422g
PPA: 
PAS_chr3_0271
VPO: 
Kpol_1042p12
ZRO: 
ZYRO0D14212g
CGR: 
CAGL0L04642g
NCS: 
NCAS_0F00340(NCAS0F00340)
NDI: 
NDAI_0K02680(NDAI0K02680)
TPF: 
TPHA_0F02600(TPHA0F02600)
TBL: 
TBLA_0A09670(TBLA0A09670)
TDL: 
TDEL_0G04050(TDEL0G04050)
KAF: 
KAFR_0G02490(KAFR0G02490)
DHA: 
DEHA2F23364g
PIC: 
PICST_61839
PGU: 
PGUG_00429
LEL: 
LELG_02472
CAL: 
CaO19.1881 CaO19.9437
CTP: 
CTRG_01687
CDU: 
CD36_21750
COT: 
CORT_0C05730
YLI: 
YALI0F19514g
CLU: 
CLUG_04619
NCR: 
NCU06194
SMP: 
SMAC_05367
PAN: 
PODANSg4820
TTT: 
THITE_2119570
MTM: 
MYCTH_2304133
MGR: 
MGG_08856
NHE: 
NECHADRAFT_70470
VAL: 
VDBG_08629
SSL: 
SS1G_00426
BFU: 
BC1G_00685
ANI: 
AN6530.2
NFI: 
NFIA_051420
AFM: 
AFUA_6G04860
AOR: 
AOR_1_96114(AO090701000052)
ANG: 
ANI_1_82134(An15g00450)
AFV: 
AFLA_055110
ACT: 
ACLA_095670
PCS: 
Pc12g04190
CIM: 
CIMG_02658
CPW: 
CPC735_037010
PBL: 
PAAG_03585
URE: 
UREG_03097
ABE: 
ARB_04117
TVE: 
TRV_03899
AJE: 
HCAG_08267
PNO: 
SNOG_15376
PTE: 
PTT_16886
ZTR: 
MYCGRDRAFT_74592
TML: 
GSTUM_00006165001
SPO: 
SPBC16A3.10
CNE: 
CNA03380
CNB: 
CNBA3250
CGI: 
CGB_B3850C
LBC: 
LACBIDRAFT_303772
MPR: 
MPER_02808
CCI: 
CC1G_08205
SCM: 
SCHCODRAFT_63856
UMA: 
UM01407.1
MGL: 
MGL_1418
PGR: 
PGTG_17666
NCE: 
NCER_100786
MBR: 
MONBRDRAFT_33064
NGR: 
NAEGRDRAFT_33112 NAEGRDRAFT_81823
DDI: 
DDB_G0278541
DPP: 
DICPUDRAFT_52171
EHI: 
EHI_086180(94.t00024)
EDI: 
EDI_249240
PTM: 
GSPATT00003417001
GLA: 
GL50803_15987
PIF: 
PITG_01330 PITG_01332 PITG_18374
 » show all
Taxonomy
Reference
1  [PMID:6250446]
  Authors
Bell RM, Coleman RA.
  Title
Enzymes of glycerolipid synthesis in eukaryotes.
  Journal
Annu. Rev. Biochem. 49 (1980) 459-87.
Reference
2  [PMID:5661029]
  Authors
Hill EE, Lands WE.
  Title
Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine.
  Journal
Biochim. Biophys. Acta. 152 (1968) 645-8.
  Organism
Rattus norvegicus [GN:rno], Cavia porcellus
Reference
3  [PMID:598375]
  Authors
Miki Y, Hosaka K, Yamashita S, Handa H, Numa S.
  Title
Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes.
  Journal
Eur. J. Biochem. 81 (1977) 433-41.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:6078124]
  Authors
van den Bosch H, van Golde LM, Eibl H, van Deenen LL.
  Title
The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes.
  Journal
Biochim. Biophys. Acta. 144 (1967) 613-23.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-64-9
DBGET integrated database retrieval system