KEGG   ENZYME: 2.3.1.24Help
Entry
EC 2.3.1.24                 Enzyme                                 
Name
sphingosine N-acyltransferase;
ceramide synthetase;
sphingosine acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:sphingosine N-acyltransferase
Reaction(IUBMB)
acyl-CoA + sphingosine = CoA + a ceramide [RN:R01496]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
sphingosine [CPD:C00319]
Product
CoA [CPD:C00010];
ceramide [CPD:C00195]
Comment
Acts on sphingosine or its 2-epimer.
Pathway
Sphingolipid metabolism
Metabolic pathways
Orthology
K04709  
Acyl-CoA-dependent ceramide synthase
K04710  
ceramide synthetase
Genes
HSA: 
10715(CERS1) 204219(CERS3) 253782(CERS6) 29956(CERS2) 79603(CERS4) 91012(CERS5)
PTR: 
451891(LASS5) 453683(LASS3) 456435(LASS4) 468773(LASS1) 469482(LASS2) 741293(LASS6)
PPS: 
100968130(CERS1) 100973710(CERS4) 100973768(CERS2) 100980816(CERS5) 100985038(CERS6) 100994802(CERS3)
GGO: 
101126713 101128445(CERS3) 101131101(CERS4) 101131185(CERS5) 101148109(CERS2)
PON: 
100174286(LASS2) 100437726(CERS4) 100447528 100451535(CERS3) 100452162(CERS6) 100454836(CERS5)
MCC: 
693696(LASS3) 704953(LASS6) 706728(LASS4) 713449(LASS5) 716180(LASS2)
MMU: 
241447(Cers6) 545975(Cers3) 67260(Cers4) 71949(Cers5) 76893(Cers2) 93898(Cers1)
RNO: 
290658(Cers1) 304208(Cers4) 310667(Cers2) 366065(Cers6) 366984(Cers5) 499174(Cers3)
CFA: 
477611(CERS5) 483187(CERS2) 485008(CERS4) 488387(CERS6) 607925(CERS3) 609789(CERS1)
AML: 
FCA: 
101084386(CERS6) 101087243(CERS5) 101089084(CERS1) 101093918(CERS4) 101094362(CERS2) 101099301(CERS3)
BTA: 
505233(CERS4) 530776(CERS5) 539223(CERS2) 614354(CERS3) 615296(CERS1) 616901(CERS6)
SSC: 
100126279(LASS6) 100127167(LASS4) 100152265(LASS3) 100156737(LASS2) 100525450 100626198
ECB: 
100050135 100052305(LASS6) 100055037(LASS2) 100059999(LASS5) 100066949 100069594
MDO: 
100014952(LASS2) 100016686 100020588 100024030(LASS6) 100025505
SHR: 
100917962(CERS2) 100919047(CERS4) 100919629(CERS3) 100924117(CERS6) 100929507(CERS5) 100934844
OAA: 
100078502 100083235 100090289 100090484
GGA: 
100857262 100859441 420050(LASS4) 426648(CERS3) 426879(CERS5) 428318(LASS4) 771503(CERS6)
MGP: 
100539644 100544401 100547857 100550977
TGU: 
100217479 100224527(CERS3) 100225623(CERS6) 100228761(CERS2) 100230030(CERS1) 100231332(CERS5)
ACS: 
100552770 100554835 100563712 100565999
XLA: 
379135(cers2) 399185(trh4) 444162(cers3) 495501(cers5)
XTR: 
100036728(cers2) 100101657(cers5) 100379773(cers4) 100485129 100489264 448139(cers3)
DRE: 
100330155 259251(cers2a) 323020(cers5) 564867 568169(fb75h07)
TRU: 
101062351 101069548 101069883 101079149 101079773
OLA: 
101156449 101160439 101166466 101175231 101175635
BFO: 
BRAFLDRAFT_104111 BRAFLDRAFT_280654
CIN: 
100101810(lag1-like3) 100184115 778663(lag1-like1)
SPU: 
582683 592336
DME: 
Dmel_CG3576(schlank)
DPO: 
Dpse_GA17532
DER: 
Dere_GG17686
DPE: 
Dper_GL21353
DSE: 
Dsec_GM12585
DWI: 
Dwil_GK25340
DYA: 
Dyak_GE16474
DGR: 
Dgri_GH24802
DMO: 
Dmoj_GI21529
DVI: 
Dvir_GJ16002
AGA: 
AgaP_AGAP001761
AAG: 
AaeL_AAEL009092
CQU: 
CpipJ_CPIJ012963
AME: 
727350(Lag1)
NVI: 
100124217(Lag1)
TCA: 
656449
API: 
100164476
PHU: 
Phum_PHUM115780
ISC: 
IscW_ISCW005009 IscW_ISCW007816 IscW_ISCW018120
CEL: 
CELE_C09G4.1(hyl-1) CELE_K02G10.6(hyl-2) CELE_Y6B3B.10(lagr-1)
CBR: 
CBG13635(Cbr-lagr-1) CBG14524(Cbr-hyl-2) CBG15635(Cbr-hyl-1)
BMY: 
Bm1_06625
TSP: 
Tsp_02045
SMM: 
Smp_042440 Smp_122050
NVE: 
NEMVE_v1g79235 NEMVE_v1g96861
HMG: 
100214724 100215789
TAD: 
TRIADDRAFT_58575
AQU: 
100641959
MTR: 
MTR_4g086150
RCU: 
RCOM_1965760
POP: 
POPTR_811133
DOSA: 
Os03t0264000-01(Os03g0264000)
BDI: 
100822162
SBI: 
SORBI_01g040200(SORBIDRAFT_01g040200) SORBI_04g029190(SORBIDRAFT_04g029190)
ZMA: 
100282886
SMO: 
SELMODRAFT_170071 SELMODRAFT_234046 SELMODRAFT_78320
PPP: 
PHYPADRAFT_115584 PHYPADRAFT_79992
CRE: 
CHLREDRAFT_105088 CHLREDRAFT_41962
VCN: 
VOLCADRAFT_55921
SCE: 
YHL003C(LAG1) YKL008C(LAC1)
AGO: 
AGOS_ABR009W AGOS_ADL206W
ERC: 
Ecym_2439 Ecym_3334
KLA: 
KLLA0B13497g KLLA0E08141g
LTH: 
KLTH0D06116g KLTH0G10582g
PPA: 
PAS_chr1-1_0358 PAS_chr2-2_0193
VPO: 
Kpol_1018p49 Kpol_1056p36
ZRO: 
ZYRO0B01276g
CGR: 
CAGL0K02739g CAGL0M10219g
NCS: 
NCAS_0A05070(NCAS0A05070)
NDI: 
NDAI_0K02120(NDAI0K02120)
TPF: 
TPHA_0C04030(TPHA0C04030) TPHA_0G03260(TPHA0G03260)
TBL: 
TBLA_0I00240(TBLA0I00240)
TDL: 
TDEL_0A02770(TDEL0A02770)
KAF: 
KAFR_0A01800(KAFR0A01800) KAFR_0D03370(KAFR0D03370)
DHA: 
DEHA2A09856g DEHA2E19954g
PIC: 
PICST_32904(LAG1.1) PICST_41505(LAG1.2) PICST_45900(LAG1.3)
PGU: 
PGUG_02003 PGUG_05077
LEL: 
LELG_00162 LELG_02788
CAL: 
CaO19.10759(LAG1) CaO19.3249(LAG1) CaO19.7354(LAC1)
CTP: 
CTRG_00979 CTRG_02454
CDU: 
CD36_26060 CD36_85670
COT: 
CORT_0A03240 CORT_0C02110
YLI: 
YALI0D04026g YALI0F06424g
CLU: 
CLUG_04758 CLUG_05416
NCR: 
NCU00008 NCU02468
SMP: 
SMAC_00102 SMAC_05999
PAN: 
PODANSg3568 PODANSg4990
TTT: 
THITE_2111280 THITE_2119256
MTM: 
MYCTH_2304458 MYCTH_2311044
MGR: 
MGG_03090 MGG_05189
FGR: 
FG05525.1 FG09423.1
NHE: 
NECHADRAFT_32956 NECHADRAFT_47179
VAL: 
VDBG_02291 VDBG_07031
SSL: 
SS1G_03198 SS1G_03317
BFU: 
BC1G_07500 BC1G_09604
ANI: 
AN2464.2 AN4332.2
NFI: 
NFIA_056240 NFIA_109860
AFM: 
AFUA_4G06290 AFUA_6G10460
AOR: 
AOR_1_1712144(AO090023000962) AOR_1_426144(AO090023000242)
ANG: 
ANI_1_1620094(An11g00990) ANI_1_194184(An04g00600) ANI_1_2320184(An04g10300)
AFV: 
AFLA_106720 AFLA_113690
ACT: 
ACLA_045600 ACLA_084070
PCS: 
Pc21g19760 Pc22g16960
CIM: 
CIMG_04183 CIMG_09385
CPW: 
CPC735_002410 CPC735_017620
PBL: 
PAAG_04385 PAAG_05548
URE: 
UREG_04929 UREG_05623
ABE: 
ARB_00488 ARB_01673 ARB_03324
TVE: 
TRV_00035 TRV_02738
AJE: 
HCAG_02470 HCAG_08955
PNO: 
SNOG_02832 SNOG_10498
PTE: 
PTT_14351 PTT_17003
ZTR: 
MYCGRDRAFT_87833
TML: 
GSTUM_00004831001 GSTUM_00010169001
SPO: 
SPAC1A6.09c(lag1) SPBC3E7.15c(lac1)
CNE: 
CNE04480
CNB: 
CNBB4850 CNBE4480 CNBE4490
CGI: 
CGB_B8100W CGB_E6060C CGB_E6070C
LBC: 
LACBIDRAFT_246245 LACBIDRAFT_246558
CCI: 
CC1G_00386
SCM: 
SCHCODRAFT_12822 SCHCODRAFT_46389
UMA: 
UM02929.1
MGL: 
MGL_3614
PGR: 
PGTG_08688 PGTG_08714
DPP: 
DICPUDRAFT_98903
 » show all
Taxonomy
Reference
1  [PMID:5973195]
  Authors
Sribney M.
  Title
Enzymatic synthesis of ceramide.
  Journal
Biochim. Biophys. Acta. 125 (1966) 542-7.
  Organism
Rattus norvegicus [GN:rno], Gallus gallus [GN:gga], Cavia porcellus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37257-09-3
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