KEGG   ENZYME: 2.3.1.26Help
Entry
EC 2.3.1.26                 Enzyme                                 
Name
sterol O-acyltransferase;
cholesterol acyltransferase;
sterol-ester synthase;
sterol-ester synthetase;
sterol-ester synthase;
acyl coenzyme A-cholesterol-O-acyltransferase;
acyl-CoA:cholesterol acyltransferase;
ACAT;
acylcoenzyme A:cholesterol O-acyltransferase;
cholesterol ester synthase;
cholesterol ester synthetase;
cholesteryl ester synthetase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:cholesterol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + cholesterol = CoA + cholesterol ester [RN:R01461]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
cholesterol [CPD:C00187]
Product
CoA [CPD:C00010];
cholesterol ester [CPD:C02530]
Comment
The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond that is nine carbon atoms distant from the carboxy group.
Pathway
Steroid biosynthesis
Orthology
K00637  
sterol O-acyltransferase
Genes
HSA: 
6646(SOAT1) 8435(SOAT2)
PTR: 
457553(SOAT1) 737291(SOAT2)
PPS: 
100990991(SOAT1) 100991938(SOAT2)
GGO: 
101137508(SOAT1) 101143800(SOAT2)
PON: 
MCC: 
701171(SOAT2) 716989(SOAT1)
MMU: 
20652(Soat1) 223920(Soat2)
RNO: 
266770(Soat2) 81782(Soat1)
CFA: 
486511(SOAT2) 490325(SOAT1)
AML: 
FCA: 
101081271(SOAT1) 101099223(SOAT2)
BTA: 
504287(SOAT1) 513554(SOAT2)
SSC: 
100515544 100628166(SOAT1)
ECB: 
100050551 100146367(SOAT2)
MDO: 
100012230 100022219(SOAT1)
SHR: 
100920315(SOAT1) 100933677(SOAT2)
OAA: 
100081816 100085367
GGA: 
424424(SOAT1)
MGP: 
100544187(SOAT1)
TGU: 
100223763(SOAT1)
ACS: 
100556270(soat1)
XLA: 
446863(soat1) 779411(soat2)
XTR: 
100145286(soat1) 100216296(soat2)
DRE: 
564424
TRU: 
101072139 101077060
OLA: 
101162519 101164716
BFO: 
BRAFLDRAFT_115379
SPU: 
583194
DME: 
Dmel_CG8112
DPO: 
Dpse_GA20833
DAN: 
Dana_GF18181
DER: 
Dere_GG12153
DPE: 
Dper_GL12471
DSE: 
Dsec_GM23753
DSI: 
Dsim_GD18564
DWI: 
Dwil_GK11809
DYA: 
Dyak_GE25896
DGR: 
Dgri_GH18571
DMO: 
Dmoj_GI24769
DVI: 
Dvir_GJ22674
AGA: 
AgaP_AGAP012216 AgaP_AGAP012217
AAG: 
AaeL_AAEL009596
CQU: 
CpipJ_CPIJ002959
AME: 
552313
NVI: 
100122384(NV14964)
TCA: 
658068 658748
PHU: 
Phum_PHUM045410
ISC: 
IscW_ISCW007924
CEL: 
CELE_B0395.2(mboa-1)
CBR: 
CBG16409
TSP: 
Tsp_07565
SMM: 
Smp_134390(are1)
NVE: 
NEMVE_v1g80875
TAD: 
TRIADDRAFT_22890
AQU: 
100639150 100639276
SCE: 
YCR048W(ARE1) YNR019W(ARE2)
AGO: 
AGOS_AAR065C
ERC: 
Ecym_2101
KLA: 
KLLA0C09152g
LTH: 
KLTH0A06204g
PPA: 
PAS_chr3_0467
VPO: 
Kpol_1027p14
ZRO: 
ZYRO0D08734g
CGR: 
CAGL0C02981g CAGL0M10571g
NCS: 
NCAS_0A04580(NCAS0A04580) NCAS_0D04420(NCAS0D04420)
NDI: 
NDAI_0I00520(NDAI0I00520) NDAI_0K01630(NDAI0K01630)
TPF: 
TPHA_0H02220(TPHA0H02220)
TBL: 
TBLA_0F04000(TBLA0F04000)
TDL: 
TDEL_0A07320(TDEL0A07320)
KAF: 
KAFR_0F00800(KAFR0F00800)
DHA: 
DEHA2F24222g
PIC: 
PICST_33115(ARE2)
PGU: 
PGUG_00464
LEL: 
LELG_02432
CAL: 
CaO19.2248(ARE2) CaO19.9788(ARE2)
CTP: 
CTRG_01764
CDU: 
CD36_21230
COT: 
CORT_0C06130
YLI: 
YALI0F06578g
CLU: 
CLUG_05837
SMP: 
SMAC_04443
PAN: 
PODANSg8191 PODANSg903
TTT: 
THITE_2108121 THITE_2110877
MTM: 
MYCTH_2301957 MYCTH_2307471
MGR: 
MGG_06765
FGR: 
FG02016.1 FG09863.1
NHE: 
NECHADRAFT_41716 NECHADRAFT_85955
VAL: 
VDBG_09403
SSL: 
SS1G_07371 SS1G_10590
BFU: 
BC1G_06963 BC1G_10262
NFI: 
NFIA_018690
AFM: 
AFUA_1G06040
AOR: 
AOR_1_800184(AO090009000480)
AFV: 
AFLA_050060
ACT: 
ACLA_028560
PCS: 
Pc13g01800 Pc13g05460
CIM: 
CIMG_03839
CPW: 
CPC735_004930
PBL: 
PAAG_01841
URE: 
UREG_02086
ABE: 
ARB_05568
TVE: 
TRV_06840
AJE: 
HCAG_00155
PNO: 
SNOG_02790 SNOG_11748
PTE: 
PTT_18164 PTT_20058
ZTR: 
MYCGRDRAFT_41169 MYCGRDRAFT_44439(ARE1)
TML: 
GSTUM_00000025001 GSTUM_00001327001
SPO: 
SPAC13G7.05(are1)
CNE: 
CNF01130
CNB: 
CNBF3580
CGI: 
CGB_F5190W
LBC: 
LACBIDRAFT_188091
CCI: 
CC1G_00886
SCM: 
SCHCODRAFT_53724
UMA: 
UM05355.1
MGL: 
MGL_2868
PGR: 
PGTG_16235
TGO: 
TGME49_063710
TET: 
TTHERM_00046260 TTHERM_00732710 TTHERM_00895740
PTM: 
GSPATT00019987001 GSPATT00022217001 GSPATT00022973001
PIF: 
PITG_12278
 » show all
Taxonomy
Reference
1  [PMID:5439042]
  Authors
Sgoutas DS.
  Title
Effect of geometry and position of ethylenic bond upon acyl coenzyme A--cholesterol-O-acyltransferase.
  Journal
Biochemistry. 9 (1970) 1826-33.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:42927]
  Authors
Spector AA, Mathur SN, Kaduce TL.
  Title
Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol metabolism.
  Journal
Prog. Lipid. Res. 18 (1979) 31-53.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:389289]
  Authors
Taketani S, Nishino T, Katsuki H.
  Title
Characterization of sterol-ester synthetase in Saccharomyces cerevisiae.
  Journal
Biochim. Biophys. Acta. 575 (1979) 148-55.
  Organism
Saccharomyces cerevisiae [GN:sce]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-63-8
DBGET integrated database retrieval system