KEGG   ENZYME: 2.3.1.26Help
Entry
EC 2.3.1.26                 Enzyme                                 
Name sterol O-acyltransferase;
cholesterol acyltransferase;
sterol-ester synthase;
sterol-ester synthetase;
sterol-ester synthase;
acyl coenzyme A-cholesterol-O-acyltransferase;
acyl-CoA:cholesterol acyltransferase;
ACAT;
acylcoenzyme A:cholesterol O-acyltransferase;
cholesterol ester synthase;
cholesterol ester synthetase;
cholesteryl ester synthetase
Class Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname acyl-CoA:cholesterol O-acyltransferase
Reaction(IUBMB) acyl-CoA + cholesterol = CoA + cholesterol ester [RN:R01461]
Reaction(KEGG) R01461
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Substrate acyl-CoA [CPD:C00040];
cholesterol [CPD:C00187]
Product CoA [CPD:C00010];
cholesterol ester [CPD:C02530]
Comment The animal enzyme is highly specific for transfer of acyl groups
with a single cis double bond that is nine carbon atoms distant from
the carboxy group.
Pathway PATH: ec00100  Steroid biosynthesis
Orthology KO: K00637  sterol O-acyltransferase
Genes HSA: 6646(SOAT1) 8435(SOAT2)
PTR: 457553(SOAT1) 737291(SOAT2)
MCC: 701171(SOAT2)
MMU: 20652(Soat1) 223920(Soat2)
RNO: 266770(Soat2) 81782(Soat1)
CFA: 486511(SOAT2) 490325(SOAT1)
BTA: 504287(SOAT1) 513554(SOAT2)
ECB: 100050551 100146367
MDO: 100012230 100022219(SOAT1)
OAA: 100081816
GGA: 424424(SOAT1)
TGU: 100223763
XLA: 446863(soat1) 779411(soat2)
DRE: 100150545 564424(DKEY-21P1.4)
BFO: BRAFLDRAFT_115379
SPU: 583194
DME: Dmel_CG8112
DPO: Dpse_GA20833
DAN: Dana_GF18181
DER: Dere_GG12153
DPE: Dper_GL12471
DSE: Dsec_GM23753
DSI: Dsim_GD18564
DYA: Dyak_GE25896
DGR: Dgri_GH18571
DMO: Dmoj_GI24769
AGA: AgaP_AGAP012216 AgaP_AGAP012217
AAG: AaeL_AAEL009596
CQU: CpipJ_CPIJ002959
AME: 552313
NVI: 100122384
TCA: 658068 658748
ISC: IscW_ISCW007924
CEL: B0395.2
CBR: CBG16409
SMM: Smp_134390(are1)
NVE: NEMVE_v1g80875
TAD: TRIADDRAFT_22890
SCE: YCR048W(ARE1) YNR019W(ARE2)
AGO: AGOS_AAR065C
KLA: KLLA0C09152g
LTH: KLTH0A06204g
PIC: PICST_33115(ARE2)
PPA: PAS_chr3_0467
VPO: Kpol_1027p14
LEL: LELG_02432
ZRO: ZYRO0D08734g
CTP: CTRG_01764
CDU: CD36_21230
CGR: CAGL0C02981g CAGL0M10571g
YLI: YALI0F06578g
SPO: SPAC13G7.05
PAN: PODANSg8191 PODANSg903
MGR: MGG_06765
FGR: FG02016.1
AFM: AFUA_1G06040
AOR: AO090009000480
ANG: An18g04660
AFV: AFLA_050060
PCS: Pc13g01800 Pc13g05460
NFI: NFIA_018690
CIM: CIMG_03839
URE: UREG_02086
SSL: SS1G_07371
BFU: BC1G_10262
CNE: CNF01130
CNB: CNBF3580
LBC: LACBIDRAFT_188091
UMA: UM05355.1
MGL: MGL_2868
TET: TTHERM_00046260 TTHERM_00732710 TTHERM_00895740
PTM: GSPATT00019987001 GSPATT00020321001 GSPATT00022217001
     GSPATT00022973001
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:5439042]
Sgoutas DS.
Effect of geometry and position of ethylenic bond upon acyl coenzyme
A--cholesterol-O-acyltransferase.
Biochemistry. 9 (1970) 1826-33.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:42927]
Spector AA, Mathur SN, Kaduce TL.
Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol
metabolism.
Prog. Lipid. Res. 18 (1979) 31-53.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:389289]
Taketani S, Nishino T, Katsuki H.
Characterization of sterol-ester synthetase in Saccharomyces
cerevisiae.
Biochim. Biophys. Acta. 575 (1979) 148-55.
Saccharomyces cerevisiae [GN:sce]
Other DBs ExplorEnz - The Enzyme Database: 2.3.1.26
IUBMB Enzyme Nomenclature: 2.3.1.26
ExPASy - ENZYME nomenclature database: 2.3.1.26
BRENDA, the Enzyme Database: 2.3.1.26
CAS: 9027-63-8
DBGET integrated database retrieval system