KEGG   ENZYME: 2.3.1.26Help
Entry
EC 2.3.1.26                 Enzyme                                 

Name
sterol O-acyltransferase;
cholesterol acyltransferase;
sterol-ester synthase;
sterol-ester synthetase;
sterol-ester synthase;
acyl coenzyme A-cholesterol-O-acyltransferase;
acyl-CoA:cholesterol acyltransferase;
ACAT;
acylcoenzyme A:cholesterol O-acyltransferase;
cholesterol ester synthase;
cholesterol ester synthetase;
cholesteryl ester synthetase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:cholesterol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + cholesterol = CoA + cholesterol ester [RN:R01461]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
cholesterol [CPD:C00187]
Product
CoA [CPD:C00010];
cholesterol ester [CPD:C02530]
Comment
The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond that is nine carbon atoms distant from the carboxy group.
History
EC 2.3.1.26 created 1972
Pathway
Steroid biosynthesis
Orthology
K00637  
sterol O-acyltransferase
Genes
HSA: 
6646(SOAT1) 8435(SOAT2)
PTR: 
457553(SOAT1) 737291(SOAT2)
PPS: 
100990991(SOAT1) 100991938(SOAT2)
GGO: 
101137508(SOAT1) 101143800(SOAT2)
PON: 
MCC: 
701171(SOAT2) 716989(SOAT1)
MCF: 
102121286(SOAT1) 102135925(SOAT2)
MMU: 
20652(Soat1) 223920(Soat2)
RNO: 
266770(Soat2) 81782(Soat1)
CGE: 
100689317(Soat1) 100752385(Soat2)
HGL: 
101718579(Soat2) 101725301(Soat1)
TUP: 
102485090(SOAT1) 102501974(SOAT2)
CFA: 
486511(SOAT2) 490325(SOAT1)
AML: 
FCA: 
101081271(SOAT1) 101099223(SOAT2)
BTA: 
504287(SOAT1) 513554(SOAT2)
BOM: 
102266586(SOAT1) 102286882(SOAT2)
PHD: 
102325324(SOAT1) 102341784(SOAT2)
CHX: 
102181472(SOAT2) 102186791(SOAT1)
SSC: 
100515544(SOAT2) 100628166(SOAT1)
CFR: 
102509905(SOAT2) 102517625(SOAT1)
ECB: 
100050551(SOAT1) 100146367(SOAT2)
MYB: 
102251864(SOAT1) 102258914(SOAT2)
MDO: 
SHR: 
100920315(SOAT1) 100933677(SOAT2)
OAA: 
GGA: 
424424(SOAT1)
MGP: 
100544187(SOAT1)
TGU: 
100223763(SOAT1)
FAB: 
101815412(SOAT1)
PHI: 
102102644(SOAT1)
APLA: 
101790922(SOAT1)
FPG: 
101919752(SOAT1)
FCH: 
102060236(SOAT1)
CLV: 
102098103(SOAT1)
ASN: 
102373020(SOAT1)
PSS: 
102448344(SOAT1)
ACS: 
100556270(soat1)
XLA: 
446863(soat1) 779411(soat2)
XTR: 
100145286(soat1) 100216296(soat2)
DRE: 
564424(soat1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
552313(GB16016)
NVI: 
TCA: 
BMOR: 
PHU: 
ISC: 
CEL: 
CELE_B0395.2(mboa-1)
CBR: 
LOA: 
TSP: 
SMM: 
NVE: 
TAD: 
AQU: 
CME: 
GSL: 
SCE: 
YCR048W(ARE1) YNR019W(ARE2)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A04580(NCAS0A04580) NCAS_0D04420(NCAS0D04420)
NDI: 
NDAI_0I00520(NDAI0I00520) NDAI_0K01630(NDAI0K01630)
TPF: 
TPHA_0H02220(TPHA0H02220)
TBL: 
TBLA_0F04000(TBLA0F04000)
TDL: 
TDEL_0A07320(TDEL0A07320)
KAF: 
KAFR_0F00800(KAFR0F00800)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
NFI: 
AFM: 
AOR: 
AOR_1_800184(AO090009000480)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
LBC: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
ACAN: 
TGO: 
TET: 
PTM: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:5439042]
  Authors
Sgoutas DS.
  Title
Effect of geometry and position of ethylenic bond upon acyl coenzyme A--cholesterol-O-acyltransferase.
  Journal
Biochemistry. 9 (1970) 1826-33.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:42927]
  Authors
Spector AA, Mathur SN, Kaduce TL.
  Title
Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol metabolism.
  Journal
Prog. Lipid. Res. 18 (1979) 31-53.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:389289]
  Authors
Taketani S, Nishino T, Katsuki H.
  Title
Characterization of sterol-ester synthetase in Saccharomyces cerevisiae.
  Journal
Biochim. Biophys. Acta. 575 (1979) 148-55.
  Organism
Saccharomyces cerevisiae [GN:sce]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-63-8

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