KEGG   ENZYME: 2.3.1.28Help
Entry
EC 2.3.1.28                 Enzyme                                 
Name
chloramphenicol O-acetyltransferase;
chloramphenicol acetyltransferase;
chloramphenicol acetylase;
chloramphenicol transacetylase;
CAT I;
CAT II;
CAT III
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:chloramphenicol 3-O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate [RN:R03065]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
chloramphenicol [CPD:C00918]
Product
CoA [CPD:C00010];
chloramphenicol 3-acetate [CPD:C03601]
Orthology
K00638  
chloramphenicol O-acetyltransferase
Genes
BMY: 
NCR: 
EOI: 
ECM: 
EUM: 
STY: 
SEC: 
SC011(cat2)
SEW: 
YEP: 
PLU: 
PAY: 
PAU_01227
ENT: 
Ent638_1533
KPN: 
KPN_02018 KPN_pKPN5p08234(cmlA2)
KPU: 
KP1_3094
KPM: 
KPHS_29990
KPE: 
KPK_2323
KVA: 
Kvar_2281
KOX: 
KOX_22265
SPE: 
Spro_3345
PMR: 
PMI0728(cat) PMI1693
ETR: 
ETAE_p044
XBO: 
XBJ1_0111 XBJ1_0801
VCH: 
VCA0253 VCA0300
VCJ: 
VCD_000003 VCD_000980
VCO: 
VC0395_0977
VCM: 
VCM66_A0249
VVU: 
VV2_0610
VVY: 
VVA1162
VPA: 
VPA0028 VPA1748
VHA: 
VIBHAR_07054
VSP: 
VS_1576 VS_II0508
VEX: 
VEA_000461 VEA_000997
VFI: 
VF_A0790
VFM: 
VFMJ11_A0054 VFMJ11_A0917
VSA: 
VSAL_I2074
PPR: 
PBPRB0068
PAE: 
PA0706(cat)
PAU: 
PA14_55170(cat)
PAP: 
PSPA7_4187 PSPA7_4802
PAG: 
PLES_46241(cat)
PDK: 
PADK2_22105
PFL: 
PFL_2085(cat)
PEN: 
PSEEN4077
ACD: 
AOLE_03795
ACB: 
A1S_2691
ABY: 
ABAYE0798(cat) ABAYE3587(cat)
ABC: 
ACICU_02932
ABN: 
AB57_0280(cat) AB57_3104
ABB: 
ABBFA_000784
SON: 
SO_4299(catB)
SAZ: 
Sama_1384
SBM: 
Shew185_4229
SBN: 
Sbal195_1998 Sbal195_4361
SBP: 
Sbal223_4157
SLO: 
Shew_1536
SSE: 
Ssed_0017 Ssed_2793
SPL: 
Spea_2289
SHN: 
Shewana3_0322
SHL: 
Shal_2005
SWP: 
swp_3996
SVO: 
SVI_3074(cat)
PHA: 
PSHAa1168
MAQ: 
Maqu_1388
FBL: 
Fbal_2105 Fbal_3279
LPN: 
lpg0047
LPF: 
lpl0046
LPP: 
lpp0048
LPC: 
LPC_0050
LPA: 
lpa_00064
MMW: 
Mmwyl1_2950
AHA: 
AHA_0037 AHA_3656
ASA: 
ASA_3623 ASA_P4G101(cat)
ABU: 
Abu_0782(cat)
DVU: 
DVU1992
DVL: 
Dvul_1087 Dvul_1181
DDE: 
Dde_1494
DMA: 
DMR_43300(cat)
DSA: 
Desal_2296
DPS: 
DP1720 DP2058
RBE: 
RBE_0484
RBO: 
A1I_02800
MLO: 
mll2311
ATU: 
Atu4738(cat)
BME: 
BMEI0594
BMF: 
BAB1_1434
SIT: 
TM1040_2320
RSH: 
Rsph17029_3561
RSK: 
RSKD131_4210
JAN: 
Jann_0057
PDE: 
Pden_0116
ZMO: 
ZMO1143
BLI: 
BL03127(cat)
BLD: 
BLi02835
BAE: 
BATR1942_06305
BAN: 
BA_2409
BAR: 
GBAA_2409
BAT: 
BAS2245
BAH: 
BAMEG_2189
BAI: 
BAA_2468
BAL: 
BACI_c23590 BACI_c24690
BCE: 
BC2447 BC3545
BCA: 
BCE_2444
BCZ: 
BCZK2165(cat)
BCB: 
BCB4264_A2376 BCB4264_A2456
BCU: 
BCAH820_2426
BCG: 
BCG9842_B2880 BCG9842_B2956
BCX: 
BCA_2477 BCA_2583
BTK: 
BT9727_2179(cat)
BTL: 
BALH_2148 BALH_2245 BALH_3185
BTB: 
BMB171_C2202
BWE: 
BcerKBAB4_2222 BcerKBAB4_2303 BcerKBAB4_5557
BCL: 
ABC1978
BPU: 
BPUM_1131(cat)
LSP: 
Bsph_2999
EAT: 
EAT1b_1568
BBE: 
BBR47_14680(cat)
GYM: 
GYMC10_1214 GYMC10_3621
SPW: 
SPCG_1228 SPCG_1292
SNE: 
SPN23F_12590
SPV: 
SPH_1266
SNM: 
SP70585_1092
SNB: 
SP670_1139
SSB: 
SSUBM407_0980(cat)
LPL: 
lp_1787(cat)
LPJ: 
JDM1_1505(cat)
LPS: 
LPST_C1432(cat)
LSA: 
LSA1239
LBR: 
LVIS_1824
MPS: 
MPTP_0065
CAC: 
CA_C0235 CA_P0060(cat)
CTC: 
CTC01425
CBO: 
CBO0619(cat) CBO1547 CBO2021(catB)
CBA: 
CLB_0659(cat-1) CLB_1568(cat-2) CLB_1961(cat-3)
CBH: 
CLC_0674(cat-1) CLC_1966(cat-2)
CBY: 
CLM_0727 CLM_1026 CLM_2238(catB)
CBL: 
CLK_0019(cat) CLK_1027(cat) CLK_1474
CBK: 
CLL_A2128 CLL_A2166
CBB: 
CLD_0021 CLD_2604(cat)
CBI: 
CLJ_B0701(cat) CLJ_B2225 CLJ_B3111
CBT: 
CLH_2469
CBF: 
CLI_0699(cat-1) CLI_2087(cat-2)
CBE: 
Cbei_2295 Cbei_3217
CCE: 
Ccel_1049
CLJ: 
CLJU_c25940(cat)
CSH: 
Closa_2863
CCB: 
Clocel_1050
CDC: 
CD196_3415
CDL: 
CDR20291_3461
BPB: 
bpr_I2238(cat)
CLE: 
Clole_1986 Clole_2870
OVA: 
OBV_20840 OBV_30800 OBV_32740(cat)
HOR: 
Hore_13840
MAB: 
MAB_2989
RHA: 
RHA1_ro02201
XCE: 
Xcel_3311
SKE: 
Sked_12550
SEN: 
SACE_3683
BHY: 
BHWA1_02596(cat)
BPO: 
BP951000_0885(cat)
ACM: 
AciX9_2433
BTH: 
BT_0702 BT_3119
BFR: 
BF2405 BF4582
BFS: 
BF2487 BF4368
BVU: 
BVU_1202 BVU_3261
PDI: 
BDI_3317
PPN: 
Palpr_0485
OSP: 
Odosp_2424
PRU: 
PRU_0509
SHG: 
Sph21_3786 Sph21_4488
HHY: 
Halhy_4054
FJO: 
Fjoh_0863
FBR: 
FBFL15_2306(cat)
ZPR: 
ZPR_3084
CAO: 
Celal_2906
CLY: 
Celly_2361
KDI: 
Krodi_1316
LAN: 
Lacal_2637
FSU: 
Fisuc_0604
AMU: 
Amuc_0333
SYF: 
Synpcc7942_0704
CYP: 
PCC8801_2049
CYH: 
Cyan8802_2073
HAU: 
Haur_2115
DRA: 
DR_2303
MMP: 
MMP1355
MMQ: 
MmarC5_0223
MMX: 
MmarC6_1318
MMZ: 
MmarC7_0600
MVN: 
Mevan_0665
MVO: 
Mvol_0349
MAC: 
MA1703(cat)
MBA: 
Mbar_A2711
MMA: 
MM_2551
MSI: 
Msm_0047
MRU: 
mru_0422
 » show all
Taxonomy
Reference
1  [PMID:5335032]
  Authors
Shaw WV.
  Title
The enzymatic acetylation of chloramphenicol by extracts of R factor-resistant Escherichia coli.
  Journal
J. Biol. Chem. 242 (1967) 687-93.
  Organism
Escherichia coli [GN:eco]
Reference
2  [PMID:4965980]
  Authors
Shaw WV, Brodsky RF.
  Title
Characterization of chloramphenicol acetyltransferase from chloramphenicol-resistant Staphylococcus aureus.
  Journal
J. Bacteriol. 95 (1968) 28-36.
  Organism
Staphylococcus aureus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9040-07-7
DBGET integrated database retrieval system