| Entry |
|
|---|
| Name |
glycine C-acetyltransferase;
2-amino-3-ketobutyrate CoA ligase;
2-amino-3-ketobutyrate coenzyme A ligase;
2-amino-3-ketobutyrate-CoA ligase;
glycine acetyltransferase;
aminoacetone synthase;
aminoacetone synthetase;
KBL;
AKB ligase |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
acetyl-CoA:glycine C-acetyltransferase |
|---|
| Reaction(IUBMB) |
acetyl-CoA + glycine = CoA + L-2-amino-3-oxobutanoate [RN:R00371] |
|---|
| Reaction(KEGG) |
R00371
 |
|---|
| Substrate |
acetyl-CoA [CPD:C00024];
glycine [CPD:C00037] |
|---|
| Product |
CoA [CPD:C00010];
L-2-amino-3-oxobutanoate [CPD:C03508] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
This is a pyridoxal-phosphate-dependent enzyme that acts in concert
with EC 1.1.1.103, L-threonine 3-dehydrogenase, in the degradation
of threonine to form glycine [3]. This threonine degradation pathway
is common to prokaryotic and eukaryotic cells and the two enzymes
involved form a complex [4]. |
|---|
| Pathway |
PATH: ec00260 Glycine, serine and threonine metabolism |
|---|
| Orthology |
KO: K00639 glycine C-acetyltransferase |
|---|
| Genes |
HSA: 23464(GCAT)
PTR: 458820(GCAT)
MCC: 698811(GCAT)
MMU: 26912(Gcat)
RNO: 366959(Gcat)
CFA: 481262(GCAT)
BTA: 319141(GCAT)
ECB: 100069889
MDO: 100032583
GGA: 427905(GCAT)
TGU: 100230135
XLA: 380495(gcat)
XTR: 394899
DRE: 402822(gcat)
BFO: BRAFLDRAFT_113546
CIN: 100179233
SPU: 583773
DME: Dmel_CG10361
DPO: Dpse_GA10272
DAN: Dana_GF24511
DER: Dere_GG13887
DPE: Dper_GL20821
DSE: Dsec_GM24709
DYA: Dyak_GE20178
DGR: Dgri_GH16379
DMO: Dmoj_GI11571
AGA: AgaP_AGAP005781
AAG: AaeL_AAEL012318
CQU: CpipJ_CPIJ005691
AME: 411916
NVI: 100121329
ISC: IscW_ISCW015295
CEL: T25B9.1
CBR: CBG17650
BMY: Bm1_01535
NVE: NEMVE_v1g113623 NEMVE_v1g231555
HMG: 100214553
TAD: TRIADDRAFT_19375
CME: CMO139C
MBR: MONBRDRAFT_10030
TET: TTHERM_01107480
PTM: GSPATT00027895001
TBR: Tb927.8.6060
TCR: 511071.140 511899.40
ECO: b3617(kbl)
ECJ: JW3592(kbl)
ECD: ECDH10B_3799(kbl)
EBW: BWG_3308(kbl)
ECE: Z5044(kbl)
ECS: ECs4495
ECF: ECH74115_4990(kbl)
ETW: ECSP_4614(kbl)
ECG: E2348C_3866(kbl)
ECC: c4444(kbl)
ECI: UTI89_C4163(kbl)
ECP: ECP_3718
ECV: APECO1_2838(kbl)
ECW: EcE24377A_4121(kbl)
ECX: EcHS_A3829(kbl)
ECM: EcSMS35_3954(kbl)
ECY: ECSE_3900
ECL: EcolC_0091
ECK: EC55989_4084(kbl)
ECQ: ECED1_4303(kbl)
ECR: ECIAI1_3790(kbl)
ECT: ECIAI39_4138(kbl)
ECZ: ECS88_4034(kbl)
EUM: ECUMN_4134(kbl)
ELF: LF82_1140(kbl)
EBL: B21_03426(kbl)
EBD: ECBD_0108
EBR: ECB_03475(kbl)
EOH: ECO103_4562(kbl)
EOI: ECO111_4442(kbl)
EOJ: ECO26_4980(kbl)
EFE: EFER_3907(kbl)
STY: STY4086(kbl)
STT: t3810(kbl)
SPT: SPA3561(kbl)
SEK: SSPA3324
SPQ: SPAB_04606
SEI: SPC_3791(kbl)
SEC: SC3632(kbl)
SEH: SeHA_C4034(kbl)
SEE: SNSL254_A3989(kbl)
SEW: SeSA_A3908(kbl)
SEA: SeAg_B3927(kbl)
SED: SeD_A4095(kbl)
SEG: SG3722(kbl)
SET: SEN3531(kbl)
SES: SARI_03932
STM: STM3709(kbl)
YPE: YPO0059(kbl)
YPK: y0081(kbl)
YPM: YP_0060(kbl)
YPA: YPA_3483
YPN: YPN_3791
YPG: YpAngola_A0065(kbl)
YPP: YPDSF_3846
YPS: YPTB0056(kbl)
YPI: YpsIP31758_0071(kbl)
YPY: YPK_4145
YPB: YPTS_0058
YEN: YE0073(kbl)
SFL: SF3657(kbl)
SFX: S4110(kbl)
SFV: SFV_3911(kbl)
SSN: SSON_3787(kbl)
SBO: SBO_3623(kbl)
SBC: SbBS512_E4045(kbl)
SDY: SDY_4050(kbl)
ECA: ECA0167(kbl)
PCT: PC1_4087
PWA: Pecwa_4368
ETA: ETA_13580
PLU: plu4846(kbl)
PAY: PAU_04352(kbl)
ENT: Ent638_0118
ESA: ESA_04110
CTU: Ctu_41290(kbl)
KPN: KPN_03962(kbl)
KPE: KPK_0134(kbl)
KPU: KP1_5312(kbl)
CKO: CKO_05077
SPE: Spro_4824
PMR: PMI3177(kbl)
EIC: NT01EI_0073
ETR: ETAE_0084(kbl)
DDA: Dd703_0174
DDC: Dd586_0165
DZE: Dd1591_3945
XCC: XCC0939(kbl)
XCB: XC_3296
XCA: xccb100_3414
XCV: XCV1046(kbl)
XAC: XAC1016(kbl)
XOO: XOO3691(kbl)
XOM: XOO_3486
XOP: PXO_02519(kbl)
SML: Smlt0959(kbl)
SMT: Smal_0804
VCH: VCA0886
VCO: VC0395_0352(kbl)
VCM: VCM66_A0846(kbl)
VCJ: VCD_000447
VVU: VV2_1484
VVY: VVA0304
VPA: VPA1510
VHA: VIBHAR_05000
VSP: VS_II0436
VEX: VEA_001212
VFI: VF_A0418(kbl)
VFM: VFMJ11_A0461(kbl)
VSA: VSAL_II0836(kbl)
PPR: PBPRA1729
SON: SO_4674(kbl)
SDN: Sden_3615
SFR: Sfri_3938
SAZ: Sama_0098
SBL: Sbal_0058
SBM: Shew185_4340
SBN: Sbal195_4480
SBP: Sbal223_4285
SLO: Shew_3709
SPC: Sputcn32_3901
SSE: Ssed_0101
SPL: Spea_0107
SHE: Shewmr4_3900
SHM: Shewmr7_3992
SHN: Shewana3_4104
SHW: Sputw3181_0050
SHL: Shal_4215
SWD: Swoo_0065
SWP: swp_5067
ILO: IL0270(kbl)
CPS: CPS_0120(kbl)
PHA: PSHAa2316(kbl)
PAT: Patl_0061
AMC: MADE_00066
PIN: Ping_1852
CBU: CBU_0111(kbl)
CBS: COXBURSA331_A0200(kbl)
CBD: CBUD_1996(kbl)
CBG: CbuG_1901(kbl)
CBC: CbuK_1940(kbl)
LPN: lpg0701(kbl)
LPF: lpl0738(kbl)
LPP: lpp0756(kbl)
LPC: LPC_2593(kbl)
FTU: FTT_0714c(kbl)
FTF: FTF0714c(kbl)
FTW: FTW_1527(kbl)
FTL: FTL_1522
FTH: FTH_1472(kbl)
FTA: FTA_1606(kbl)
FTM: FTM_1368(kbl)
FTN: FTN_0626(kbl)
FPH: Fphi_0216
HCH: HCH_01633(kbl)
MMW: Mmwyl1_3792
AHA: AHA_4234(kbl)
ASA: ASA_0091(kbl)
KKO: Kkor_0134
CVI: CV_1650(kbl)
RSO: RSp0961(kbl)
RPI: Rpic_4847
RPF: Rpic12D_3770
REU: Reut_B4803
REH: H16_B0819(kbl)
RME: Rmet_4805
CTI: RALTA_B0638(kbl)
BMA: BMAA0005(kbl)
BMV: BMASAVP1_1151(kbl)
BML: BMA10229_1431(kbl)
BMN: BMA10247_A0006(kbl)
BPS: BPSS0005(kbl)
BPM: BURPS1710b_A1510(kbl)
BPL: BURPS1106A_A0005(kbl)
BPD: BURPS668_A0005(kbl)
BTE: BTH_II0005(kbl)
BVI: Bcep1808_3788
BUR: Bcep18194_A4993 Bcep18194_B3179
BCN: Bcen_5158
BCH: Bcen2424_5701
BCM: Bcenmc03_4536
BCJ: BCAM0010(kbl)
BAM: Bamb_4972
BAC: BamMC406_3115
BMU: Bmul_5321
BMJ: BMULJ_03200(kbl)
BXE: Bxe_B3021
BPH: Bphy_4159
BPY: Bphyt_7004
BGL: bglu_2g00090
POL: Bpro_4366
TMZ: Tmz1t_0529
TBD: Tbd_0669
GSU: GSU2629(bioF)
GME: Gmet_0842
GUR: Gura_3246
GLO: Glov_1662
GBM: Gbem_0049 Gbem_0831
GEO: Geob_2084
GEM: GM21_0048 GM21_3430
DDS: Ddes_0423
DMA: DMR_42870(kbl)
DSA: Desal_2895
DBA: Dbac_2687
DAT: HRM2_09040(bioF)
ADE: Adeh_2094
ACP: A2cp1_1863
AFW: Anae109_2930
ANK: AnaeK_1784
MXA: MXAN_0841
SCL: sce7278(kbl)
HOH: Hoch_6614
SAT: SYN_00565
SFU: Sfum_2235
MLO: mll9204 mlr8297
MES: Meso_0443
SME: SMc01565(kbl)
SMD: Smed_2225
ARA: Arad_3119(kbl)
RET: RHE_CH02952(kbl)
REC: RHECIAT_CH0003118(kbl)
RLE: RL3405(kbl)
RLT: Rleg2_2701
RLG: Rleg_2959
RHI: NGR_c22700(kbl)
BBT: BBta_1580
MEA: Mex_1p0374
MDI: METDI0525
MPO: Mpop_0525
MCH: Mchl_0489
CCS: CCNA_01220
CAK: Caul_1685
PZU: PHZ_c2053
SIL: SPO3360(kbl)
SIT: TM1040_3024
RSP: RSP_2376(kbl)
RSH: Rsph17029_1036
RSQ: Rsph17025_1900
RSK: RSKD131_0688
RDE: RD1_0199(kbl)
MMR: Mmar10_1598
ZMN: Za10_0070
NAR: Saro_3111
SAL: Sala_2171
SWI: Swit_3900
GDI: GDI_2928(kbl)
GDJ: Gdia_3421
APT: APA01_16060
RCE: RC1_0748(bioF)
BSU: BSU17000(kbl)
BAN: BA0620
BAR: GBAA0620
BAA: BA_1203
BAT: BAS0586
BAH: BAMEG_3967
BAI: BAA_0702
BCE: BC0621
BCA: BCE_0688
BCZ: BCZK0530(bioF)
BCR: BCAH187_A0748
BCB: BCB4264_A0657
BCU: BCAH820_0675
BCG: BCG9842_B4680
BCQ: BCQ_0685(bioF)
BCX: BCA_0654
BCY: Bcer98_0533
BTK: BT9727_0530(bioF)
BTL: BALH_0558(kbl)
BWE: BcerKBAB4_0534
BLI: BL03659(kbl)
BLD: BLi01924(kbl)
BAY: RBAM_016840(kbl)
BPU: BPUM_1604(kbl)
OIH: OB3054
GYM: GYMC10_4681
SAU: SA0508
SAV: SAV0550
SAW: SAHV_0548
SAM: MW0505
SAR: SAR0555(kbl)
SAS: SAS0508
SAC: SACOL0596
SAB: SAB0501(kbl)
SAA: SAUSA300_0535
SAX: USA300HOU_0543(kbl)
SAO: SAOUHSC_00532
SAJ: SaurJH9_0573
SAH: SaurJH1_0587
SAE: NWMN_0512
SAD: SAAV_0513
SHA: SH2457
SSP: SSP2205
SCA: Sca_0209(kbl)
LSP: Bsph_0909
ESI: Exig_1033
EAT: EAT1b_0424
MCL: MCCL_1857
BBE: BBR47_25950(kbl)
LSA: LSA0509(kbl)
CTH: Cthe_0022
AMT: Amet_3634
AOE: Clos_0909
STH: STH1872
VPR: Vpar_1005
ATE: Athe_2207
TTE: TTE2406(bioF)
TEX: Teth514_0779
TPD: Teth39_0287
CSC: Csac_1225
CPO: COPRO5265_1289(bioF)
NTH: Nther_0292
MMO: MMOB5780(bioF)
MMI: MMAR_1724(bioF2_2) MMAR_4628(bioF2_1)
ROP: ROP_22760
SCO: SCO6800(kbl)
SMA: SAV_1627(kbl)
SGR: SGR_1443
ART: Arth_1311
AAU: AAur_1460(kbl)
ACH: Achl_1354
RSA: RSal33209_1302
BCV: Bcav_0836
BFA: Bfae_02780
KSE: Ksed_10060
PAC: PPA0403
NCA: Noca_3756
SRO: Sros_8853
NML: Namu_1029
SEN: SACE_4477(bioF) SACE_6390(kbl)
AMI: Amir_3110 Amir_7064
PCU: pc0811
TDE: TDE2194
ABA: Acid345_3919
ACA: ACP_1916(bioF)
SUS: Acid_5166
BTH: BT_1371
BFR: BF2988
BFS: BF2864(kbl)
BVU: BVU_0981
PGI: PG0481(kbl)
PGN: PGN_1489
PDI: BDI_1237 BDI_1877 BDI_2951
SRU: SRU_0382(kbl)
RMR: Rmar_0699
CHU: CHU_1310(kbl)
DFE: Dfer_3258 Dfer_4407
CPI: Cpin_0908 Cpin_1664
PHE: Phep_2862 Phep_3321 Phep_3628
GFO: GFO_3375(kbl)
FJO: Fjoh_0698 Fjoh_2419
FPS: FP0157(kbl) FP1804
FBA: FIC_00804 FIC_01299
COC: Coch_1830
RBI: RB2501_07495 RB2501_15544
FSU: Fisuc_2955
OTE: Oter_2658 Oter_2922
AMU: Amuc_0077
GAU: GAU_0656(kbl)
EMI: Emin_0147
RSD: TGRD_561
TAI: Taci_1652
PPH: Ppha_2789
CAG: Cagg_0385
HAU: Haur_2298
DRA: DR_2346
DGE: Dgeo_0057
DDR: Deide_22740
TTH: TTC1219
TTJ: TTHA1582
SAF: SULAZ_0385
TLE: Tlet_2009
TME: Tmel_1346
TAF: THA_1494(bioF)
FNO: Fnod_1307
PMO: Pmob_1549
KOL: Kole_2126
TAC: Ta1189
TVO: TVN0398
PHO: PH0292
PAB: PAB1244
PFU: PF0265
TKO: TK2217
TON: TON_1415
TGA: TGAM_2060(kbl)
TSI: TSIB_0100
DKA: DKAM_0818
NMR: Nmar_0819
KCR: Kcr_0632
 |
|---|
| Structures |
PDB: 1FC4 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5821726]
McGilvray D, Morris JG.
Utilization of L-threonine by a species of Arthrobacter. A novel
catabolic role for "aminoacetone synthase".
Biochem. J. 112 (1969) 657-71.
Arthrobacter sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3117785]
Mukherjee JJ, Dekker EE.
Purification, properties, and N-terminal amino acid sequence of
homogeneous Escherichia coli 2-amino-3-ketobutyrate CoA ligase, a
pyridoxal phosphate-dependent enzyme.
J. Biol. Chem. 262 (1987) 14441-7.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10712613]
Edgar AJ, Polak JM.
Molecular cloning of the human and murine 2-amino-3-ketobutyrate
coenzyme A ligase cDNAs.
Eur. J. Biochem. 267 (2000) 1805-12.
Homo sapiens [GN:hsa], Mus musculus [GN:mmu] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:11318637]
Schmidt A, Sivaraman J, Li Y, Larocque R, Barbosa JA, Smith C, Matte
A, Schrag JD, Cygler M.
Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase
from Escherichia coli complexed with a PLP-substrate intermediate:
inferred reaction mechanism.
Biochemistry. 40 (2001) 5151-60.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
|
5
(0) |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.29
IUBMB Enzyme Nomenclature: 2.3.1.29
ExPASy - ENZYME nomenclature database: 2.3.1.29
BRENDA, the Enzyme Database: 2.3.1.29
CAS: 37257-11-7 |
|---|
