KEGG   ENZYME: 2.3.1.38Help
Entry
EC 2.3.1.38                 Enzyme                                 

Name
[acyl-carrier-protein] S-acetyltransferase;
acetyl coenzyme A-acyl-carrier-protein transacylase;
[acyl-carrier-protein]acetyltransferase;
[ACP]acetyltransferase;
ACAT;
acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:[acyl-carrier protein] S-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein] [RN:R01624]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
[acyl-carrier protein] [CPD:C00229]
Product
CoA [CPD:C00010];
acetyl-[acyl-carrier protein] [CPD:C03939]
Comment
This enzyme, along with EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. The substrate acetyl-CoA protects the enzyme against inhibition by N-ethylmaleimide or iodoacetamide [4]. This is one of the activities associated with beta-ketoacyl-ACP synthase III (EC 2.3.1.180) [5].
History
EC 2.3.1.38 created 1972, modified 2006
Reference
1  [PMID:4561013]
  Authors
Prescott DJ, Vagelos PR.
  Title
Acyl carrier protein.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 36 (1972) 269-311.
Reference
2  [PMID:4698221]
  Authors
Vance DE, Mitsuhashi O, Bloch K.
  Title
Purification and properties of the fatty acid synthetase from Mycobacterium phlei.
  Journal
J. Biol. Chem. 248 (1973) 2303-9.
Reference
3  [PMID:5330116]
  Authors
Williamson IP, Wakil SJ.
  Title
Studies on the mechanism of fatty acid synthesis. XVII. Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A-acyl carrier protein transacylases.
  Journal
J. Biol. Chem. 241 (1966) 2326-32.
Reference
4  [PMID:3291856]
  Authors
Lowe PN, Rhodes S.
  Title
Purification and characterization of [acyl-carrier-protein] acetyltransferase from Escherichia coli.
  Journal
Biochem. J. 250 (1988) 789-96.
Reference
5  [PMID:1551888]
  Authors
Tsay JT, Oh W, Larson TJ, Jackowski S, Rock CO.
  Title
Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12.
  Journal
J. Biol. Chem. 267 (1992) 6807-14.
Reference
6  [PMID:9115261]
  Authors
Rangan VS, Smith S.
  Title
Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue.
  Journal
J. Biol. Chem. 272 (1997) 11975-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37257-16-2

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