| Entry |
|
|---|
| Name |
[acyl-carrier-protein] S-malonyltransferase;
[acyl carrier protein]malonyltransferase;
FabD;
malonyl coenzyme A-acyl carrier protein transacylase;
malonyl transacylase;
malonyl transferase;
malonyl-CoA-acyl carrier protein transacylase;
malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase;
malonyl-CoA:ACP transacylase;
malonyl-CoA:ACP-SH transacylase;
malonyl-CoA:AcpM transacylase;
malonyl-CoA:acyl carrier protein transacylase;
malonyl-CoA:acyl-carrier-protein transacylase;
malonyl-CoA/dephospho-CoA acyltransferase;
MAT;
MCAT;
MdcH |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
malonyl-CoA:[acyl-carrier protein] S-malonyltransferase |
|---|
| Reaction(IUBMB) |
malonyl-CoA + an [acyl-carrier protein] = CoA + a
malonyl-[acyl-carrier protein] [RN:R01626] |
|---|
| Reaction(KEGG) |
R01626
 |
|---|
| Substrate |
malonyl-CoA [CPD:C00083];
[acyl-carrier protein] [CPD:C00229] |
|---|
| Product |
CoA [CPD:C00010];
malonyl-[acyl-carrier protein] [CPD:C01209] |
|---|
| Comment |
This enzyme, along with EC 2.3.1.38, [acyl-carrier-protein]
S-acetyltransferase, is essential for the initiation of fatty-acid
biosynthesis in bacteria. This enzyme also provides the malonyl
groups for polyketide biosynthesis [7]. The product of the reaction,
malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis.
In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7,
holo-[acyl-carrier-protein] synthase) is the preferred substrate
[5]. This enzyme also forms part of the multienzyme complexes EC
4.1.1.88 (biotin-independent malonate decarboxylase) and EC 4.1.1.89
(biotin-dependent malonate decarboxylase). Malonylation of ACP is
immediately followed by decarboxylation within the
malonate-decarboxylase complex to yield acetyl-ACP, the
catalytically active species of the decarboxylase [12]. In the
enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as
a substrate but acetyl-CoA cannot [10] whereas the enzyme from
Pseudomonas putida can use both as substrates [11]. The ACP subunit
found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate
prosthetic group; that from malonate decarboxylase also contains
pantetheine-4'-phosphate but in the form of a
2'-(5-triphosphoribosyl)-3'-dephospho-CoA prosthetic group. |
|---|
| Pathway |
PATH: ec00061 Fatty acid biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00645 [acyl-carrier-protein] S-malonyltransferase |
|---|
| Genes |
HSA: 27349(MCAT)
PTR: 470233(MCAT)
MCC: 711556(MT)
MMU: 223722(Mcat)
RNO: 315173(Mcat)
CFA: 609532(MCAT)
BTA: 508130(MCAT)
ECB: 100071100
MDO: 100016042
OAA: 100079820
GGA: 427934(MCAT)
TGU: 100232649
XLA: 496310
XTR: 448008(mcat)
DRE: 564111(mcat)
BFO: BRAFLDRAFT_211460
CIN: 100178149
SPU: 592878
DME: Dmel_CG7842
DPO: Dpse_GA20625
DAN: Dana_GF10101
DER: Dere_GG13602
DPE: Dper_GL16194
DSE: Dsec_GM25683
DSI: Dsim_GD14688
DYA: Dyak_GE19897
DGR: Dgri_GH15526
DMO: Dmoj_GI16803
AGA: AgaP_AGAP005650
AAG: AaeL_AAEL002069
CQU: CpipJ_CPIJ014934
AME: 412286
TCA: 660342
API: 100159339
ISC: IscW_ISCW010461
SMM: Smp_072090.4
NVE: NEMVE_v1g143097
TAD: TRIADDRAFT_3541
ATH: AT2G30200
POP: POPTR_821336
RCU: RCOM_1403260
VVI: 100245074(GSVIVT00024012001)
OSA: 4332547(Os03g0297400)
SBI: SORBI_01g038160(SORBIDRAFT_01g038160)
ZMA: 100283964
PPP: PHYPADRAFT_73233
CRE: CHLREDRAFT_101671
OLU: OSTLU_16833 OSTLU_42236
CME: CMT420C
PIC: PICST_65214(MCT1)
PPA: PAS_chr2-1_0224
LEL: LELG_03231
SPO: SPAC11G7.05c
AFM: AFUA_4G05850
AOR: AO090672000003
ANG: An04g00040
AFV: AFLA_012430
PCS: Pc20g00410
NFI: NFIA_110320
SSL: SS1G_08176
BFU: BC1G_13188
MBR: MONBRDRAFT_35464
DDI: DDBDRAFT_0201763
PFA: PF13_0066
PFD: PFDG_00421
PFH: PFHG_02349
PYO: PY05492
PCB: PC001144.02.0
PBE: PB000845.02.0
PKN: PKH_141120
PVX: PVX_122435
TET: TTHERM_00885790
PTM: GSPATT00028833001
PTI: PHATRDRAFT_37652(FABD)
TPS: THAPSDRAFT_5219(MCT1)
ECO: b1092(fabD)
ECJ: JW1078(fabD)
ECD: ECDH10B_1164(fabD)
EBW: BWG_0940(fabD)
ECE: Z1731(fabD)
ECS: ECs1470
ECF: ECH74115_1296(fabD) ECH74115_1471(fabD)
ETW: ECSP_1224(ymdE) ECSP_1393(fabD)
ECG: E2348C_1184(fabD)
ECC: c1361(fabD)
ECI: UTI89_C1217(fabD) UTI89_C2217
ECP: ECP_1084 ECP_1974
ECV: APECO1_173(fabD)
ECW: EcE24377A_1213(fabD)
ECX: EcHS_A1214(fabD)
ECM: EcSMS35_2035(fabD)
ECY: ECSE_1156
ECL: EcolC_2509
ECK: EC55989_1143 EC55989_1204(fabD)
ECQ: ECED1_1235(fabD)
ECR: ECIAI1_1127(fabD)
ECT: ECIAI39_2069(fabD)
ECZ: ECS88_1106(fabD)
EUM: ECUMN_1267(fabD)
ELF: LF82_0606(fabD)
EBL: B21_01096(fabD)
EBD: ECBD_2509
EBR: ECB_01088(fabD)
EOH: ECO103_1137(fabD)
EOI: ECO111_1369(fabD)
EOJ: ECO26_1425(fabD)
EFE: EFER_1835(fabD)
STY: STY1233(fabD)
STT: t1726(fabD)
SPT: SPA1657(fabD)
SEK: SSPA1541
SPQ: SPAB_02329
SEI: SPC_2554(fabD)
SEC: SC1142(fabD)
SEH: SeHA_C1308(fabD)
SEE: SNSL254_A1293(fabD)
SEW: SeSA_A1264(fabD)
SEA: SeAg_B1992(fabD)
SED: SeD_A2175(fabD)
SEG: SG1928(fabD)
SET: SEN1855(fabD)
SES: SARI_01804 SARI_04164
STM: STM1194(fabD)
YPE: YPO1463 YPO1598(fabD)
YPK: y1757(fabD) y2707
YPM: YP_1355(fabD1) YP_2256(fabD2)
YPA: YPA_0756 YPA_1927
YPN: YPN_2031 YPN_2515
YPG: YpAngola_A2977 YpAngola_A3500(fabD)
YPP: YPDSF_1512 YPDSF_1849
YPS: YPTB1481 YPTB2472(fabD)
YPI: YpsIP31758_1577(fabD) YpsIP31758_2512
YPY: YPK_1685 YPK_2602
YPB: YPTS_1588 YPTS_2560
YEN: YE1634(fabD)
SFL: SF1096(fabD)
SFX: S1176(fabD)
SFV: SFV_1112(fabD)
SSN: SSON_1112(fabD)
SBO: SBO_1971(fabD)
SBC: SbBS512_E2232(fabD)
SDY: SDY_2058(fabD)
ECA: ECA1796(fabD)
PCT: PC1_2504
PWA: Pecwa_2809
ETA: ETA_20230(fabD)
PLU: plu2834(fabD)
PAY: PAU_01703(fabD)
BAS: BUsg338(fabD)
BAB: bbp320(fabD)
BCC: BCc_216(fabD)
WBR: WGLp090(fabD)
SGL: SG1059
ENT: Ent638_1607 Ent638_3772
ESA: ESA_02253
CTU: Ctu_16710(fabD) Ctu_35000
KPN: KPN_01090(fabD) KPN_01558
KPE: KPK_3466(fabD)
KPU: KP1_2081(fabD) KP1_2573
CKO: CKO_00866 CKO_01966 CKO_04762
SPE: Spro_1905
PMR: PMI0860(fabD) PMI2902
EIC: NT01EI_2370
ETR: ETAE_2100(fabD)
BFL: Bfl405(fabD)
BPN: BPEN_417(fabD)
HDE: HDEF_0446(fabD)
DDA: Dd703_1240 Dd703_1434 Dd703_1586
DDC: Dd586_1585 Dd586_2517
DZE: Dd1591_1622 Dd1591_2605
HIN: HI0156(fabD)
HIT: NTHI0245(fabD)
HIP: CGSHiEE_02505
HIQ: CGSHiGG_03375
HDU: HD0707(fabD)
HAP: HAPS_0853(fabD)
HSO: HS_0166(fabD)
HSM: HSM_0033
PMU: PM1915(fabD)
MSU: MS1873(fabD)
APL: APL_1993(fabD)
APJ: APJL_2041(fabD)
APA: APP7_2080
ASU: Asuc_2002
AAP: NT05HA_1505
AAT: D11S_2152
XFA: XF0670
XFT: PD1504(fabD)
XFM: Xfasm12_1646
XFN: XfasM23_1589
XCC: XCC1017(fabD) XCC3615(mdcH)
XCB: XC_0578 XC_3228
XCA: xccb100_0595(mdcH) xccb100_3341(fabD)
XCV: XCV0600(mdcH) XCV1145(fabD)
XAC: XAC0566(mdcH) XAC1126(fabD)
XOO: XOO0880(fabD)
XOM: XOO_0805
XOP: PXO_02708(fabD)
SML: Smlt1028(fabD) Smlt1226
SMT: Smal_0871 Smal_1075
VCH: VC2022
VCO: VC0395_A1608(fabD)
VCM: VCM66_1946(fabD)
VCJ: VCD_002345
VVU: VV1_3010
VVY: VV1274
VPA: VP2055
VHA: VIBHAR_02909
VSP: VS_1023
VEX: VEA_002995
VFI: VF_1741(fabD)
VFM: VFMJ11_1868(fabD)
VSA: VSAL_I2240(fabD)
PPR: PBPRA1194
PAE: PA0214 PA2968(fabD)
PAU: PA14_02620(mdcH) PA14_25650(fabD)
PAP: PSPA7_0298(mdcH) PSPA7_2193(fabD)
PAG: PLES_02091 PLES_20951(fabD)
PPU: PP_1913(fabD)
PPF: Pput_3801
PPG: PputGB1_1489 PputGB1_2444
PPW: PputW619_1524 PputW619_2877
PST: PSPTO_3833(fabD) PSPTO_5081
PSB: Psyr_0448 Psyr_1646
PSP: PSPPH_0439(mdcH) PSPPH_1640(fabD)
PFL: PFL_1795(fabD) PFL_5814(fabD)
PFO: Pfl01_4158 Pfl01_5296
PFS: PFLU4706 PFLU5737
PEN: PSEEN1617(fabD)
PMY: Pmen_1627
PSA: PST_2623 PST_4114
CJA: CJA_1675(fabD)
AVN: Avin_10340 Avin_14910(fabD)
PAR: Psyc_0520(fabD) Psyc_1140(mdcG)
PCR: Pcryo_0515
PRW: PsycPRwf_0456
ACI: ACIAD0870(fabD) ACIAD1759(mdcH)
ACB: A1S_0817 A1S_1427
ABM: ABSDF2641(fabD)
ABY: ABAYE2227(mdcH) ABAYE2993(fabD)
ABC: ACICU_00775 ACICU_01466
ABN: AB57_0870(fabD) AB57_1660(mdcH)
ABB: ABBFA_002060(mdcH) ABBFA_002795(fabD)
SON: SO_2777(fabD)
SDN: Sden_2294
SFR: Sfri_1498
SAZ: Sama_1981
SBL: Sbal_1718
SBM: Shew185_1715
SBN: Sbal195_1758
SBP: Sbal223_2574
SLO: Shew_1602
SPC: Sputcn32_1581
SSE: Ssed_2625
SPL: Spea_2495
SHE: Shewmr4_2397
SHM: Shewmr7_2467
SHN: Shewana3_2559
SHW: Sputw3181_2441
SHL: Shal_1776
SWD: Swoo_2041
SWP: swp_3046
ILO: IL1341(fabD)
CPS: CPS_2296(fabD)
PHA: PSHAa1809(fabD)
PAT: Patl_2123
SDE: Sde_1628
MAQ: Maqu_1868
PIN: Ping_1088 Ping_3654
TTU: TERTU_1718(fabD)
CBU: CBU_0494(fabD)
CBS: COXBURSA331_A0603(fabD)
CBD: CBUD_1582(fabD)
CBG: CbuG_1519(fabD)
CBC: CbuK_1364(fabD)
LPN: lpg1394
LPF: lpl1345(fabD)
LPP: lpp1349(fabD)
LPC: LPC_0810(fabD)
MCA: MCA2002(fabD)
FTU: FTT_1374
FTF: FTF1374
FTW: FTW_0517(fabD)
FTL: FTL_1140
FTH: FTH_1115(fabD)
FTA: FTA_1203(fabD)
FTM: FTM_0649(fabD)
FTN: FTN_1338(fabD)
FPH: Fphi_1350
TCX: Tcr_0711
NOC: Noc_1666
AEH: Mlg_1422
HHA: Hhal_1234
TGR: Tgr7_1836
HNA: Hneap_1925
HCH: HCH_02143(fabD)
CSA: Csal_1600
ABO: ABO_1068(fabD)
MMW: Mmwyl1_2131
AHA: AHA_2250(fabD)
ASA: ASA_2055(fabD)
TAU: Tola_2193
DNO: DNO_1208(fabD)
AFE: Lferr_1582
AFR: AFE_1907(fabD)
BCI: BCI_0435(fabD)
RMA: Rmag_0917
VOK: COSY_0823(fabD)
KKO: Kkor_1187
NMA: NMA0536
NME: NMB1918(fabD)
NMC: NMC0305(fabD)
NMN: NMCC_0301(fabD)
NMI: NMO_0253(fabD)
NGO: NGO2166
NGK: NGK_2645
CVI: CV_3415(fabD)
LHK: LHK_00571(fabD)
RSO: RSc1051(fabD)
RPI: Rpic_0916 Rpic_4947
RPF: Rpic12D_0981 Rpic12D_3871
REU: Reut_A2264 Reut_B4931
REH: H16_A2568(fabD)
RME: Rmet_2429
CTI: RALTA_A2071(fabD)
BMA: BMA0531(fabD-1) BMA3031 BMAA1209 BMAA1458(fabD-2)
BMV: BMASAVP1_0174 BMASAVP1_A1262 BMASAVP1_A2478(fabD)
BML: BMA10229_0451 BMA10229_2155(fabD-2) BMA10229_A0608
BMA10229_A2803(fabD-1)
BMN: BMA10247_0545 BMA10247_1801(fabD-2) BMA10247_A0839(fabD-1)
BMA10247_A1125
BPS: BPSL1335 BPSL2441(fabD) BPSS0300 BPSS1004
BPM: BURPS1710b_1590 BURPS1710b_2906(fabD) BURPS1710b_A1850(fabD)
BURPS1710b_A2616(pedD)
BPL: BURPS1106A_1488 BURPS1106A_2852(fabD) BURPS1106A_A0428(fabD)
BURPS1106A_A1389(fabD)
BPD: BURPS668_1458(fabD) BURPS668_2791(fabD) BURPS668_A0524(fabD)
BURPS668_A1475(fabD)
BPR: GBP346_A1491(mdcH) GBP346_A2972(fabD_1)
BTE: BTH_I1718(fabD-1) BTH_I2797 BTH_II2098(fabD-2)
BVI: Bcep1808_1041 Bcep1808_1229
BUR: Bcep18194_A4234 Bcep18194_A4418
BCN: Bcen_0642 Bcen_0794
BCH: Bcen2424_1122 Bcen2424_1275
BCM: Bcenmc03_1080 Bcenmc03_1247
BCJ: BCAL0993(fabD2) BCAL1246 BCAL2877(fabD1)
BAM: Bamb_0998 Bamb_1153
BAC: BamMC406_1002 BamMC406_1165
BMU: Bmul_2044 Bmul_2182
BMJ: BMULJ_01059(fabD) BMULJ_01200(fabD)
BXE: Bxe_A1073 Bxe_B1850
BPH: Bphy_0829 Bphy_5081
BPY: Bphyt_2911 Bphyt_4815
BGL: bglu_1g09520 bglu_1g11220
PNU: Pnuc_0399
PNE: Pnec_0406
BPE: BP2442(fabD)
BPA: BPP3306(fabD)
BBR: BB3757(fabD)
BPT: Bpet1754(fabD)
BAV: BAV1120(fabD)
RFR: Rfer_1731 Rfer_1849
POL: Bpro_3648
PNA: Pnap_0952 Pnap_3073
AAV: Aave_1184
AJS: Ajs_3279
VEI: Veis_2546 Veis_2890 Veis_3251
DAC: Daci_1762 Daci_5271
DIA: Dtpsy_2632
VAP: Vapar_1390 Vapar_5368
CTT: CtCNB1_0971
MPT: Mpe_A0637 Mpe_A0788
HAR: HEAR1475(mdcH) HEAR2076(fabD)
MMS: mma_0110(mdcH1) mma_1357(fabD) mma_2557(mdcH2)
LCH: Lcho_0073 Lcho_0610
NEU: NE1647(fabD)
NET: Neut_0469
NMU: Nmul_A1073
EBA: ebA5456(fabD)
AZO: azo1624(fabD)
DAR: Daro_2016 Daro_4014
TMZ: Tmz1t_2327
TBD: Tbd_1550
MFA: Mfla_1506
MMB: Mmol_1144
MEI: Msip34_1387
APP: CAP2UW1_1537
HPY: HP0090
HPJ: jhp0083(fabD)
HPA: HPAG1_0091
HPS: HPSH_00445
HPG: HPG27_83
HPP: HPP12_0093(fabD)
HPB: HELPY_0087(fabD)
HHE: HH1282(fabD)
HAC: Hac_1515(fabD)
WSU: WS0527
TDN: Suden_1393
CJE: Cj0116(fabD)
CJR: CJE0111(fabD)
CJJ: CJJ81176_0151(fabD)
CJU: C8J_0109(fabD)
CJD: JJD26997_0123(fabD)
CFF: CFF8240_1516(fabD)
CCV: CCV52592_1747(fabD)
CHA: CHAB381_0697(fabD)
CCO: CCC13826_0926(fabD)
CLA: Cla_0204(fabD)
ABU: Abu_1586(fabD)
SDL: Sdel_0525
NIS: NIS_1211(fabD)
SUN: SUN_1756(fabD)
NAM: NAMH_0331(fabD)
GSU: GSU1602(fabD)
GME: Gmet_1600
GUR: Gura_1876 Gura_3093
GLO: Glov_1938
GBM: Gbem_3107
GEO: Geob_2613
GEM: GM21_1155
PCA: Pcar_1437(fabD)
PPD: Ppro_1514 Ppro_1743
DVU: DVU1249(fabD)
DVL: Dvul_1813
DVM: DvMF_0849
DDE: Dde_2294
DDS: Ddes_0744
DMA: DMR_23290(fabD)
DSA: Desal_3757
LIP: LI0227(fabD)
DBA: Dbac_1606
DRT: Dret_1317
BBA: Bd2013(fabD) Bd3096(fabD)
DPS: DP2550
DAL: Dalk_1754 Dalk_3440
ADE: Adeh_2749
ACP: A2cp1_2933
AFW: Anae109_2738
ANK: AnaeK_2841
MXA: MXAN_3942(fabD) MXAN_4771(fabD)
SCL: sce3195 sce3816(fabD3)
HOH: Hoch_5652
SAT: SYN_01700
SFU: Sfum_3285
RPR: RP735
RTY: RT0720(fabD)
RCM: A1E_01175
RCO: RC1116(fabD)
RFE: RF_0171(fabD)
RAK: A1C_05845
RRI: A1G_06190
RRJ: RrIowa_1330
RMS: RMA_1152(fabD)
RPK: RPR_01495
RAF: RAF_ORF1024(fabD)
RBE: RBE_0671(fabD)
RBO: A1I_04145
OTS: OTBS_0743(fabD)
OTT: OTT_0593(fabD)
WOL: WD0869(fabD)
WBM: Wbm0402
WRI: WRi_008340(fabD)
WPI: WPa_0671(fabD)
AMA: AM110(fabD)
AMF: AMF_077(fabD)
ACN: ACIS_01160(fabD)
APH: APH_0092(fabD)
ERU: Erum7470(fabD)
ERW: ERWE_CDS_07870(fabD)
ERG: ERGA_CDS_07780(fabD)
ECN: Ecaj_0781
ECH: ECH_0227(fabD)
NSE: NSE_0960(fabD)
NRI: NRI_0919(fabD)
PUB: SAR11_0706(fabD)
MLO: mlr7849
MES: Meso_1769
PLA: Plav_3360
SME: SMc00571(fabD)
SMD: Smed_0744
ATU: Atu1094(fabD)
ATC: AGR_C_2025
ARA: Arad_1666(fabD)
AVI: Avi_1527(fabD)
RET: RHE_CH01442(fabD)
REC: RHECIAT_CH0001510(fabD)
RLE: RL1557(fabD)
RLT: Rleg2_1056
RLG: Rleg_1199
RHI: NGR_c08900
LAS: CLIBASIA_02115
BME: BMEI1478
BMF: BAB1_0482(fabD)
BMB: BruAb1_0479(fabD)
BMC: BAbS19_I04460
BMS: BR0457(fabD)
BMT: BSUIS_A0483(fabD)
BOV: BOV_0462(fabD)
BCS: BCAN_A0462(fabD)
BMR: BMI_I459(fabD)
OAN: Oant_0570
BJA: bll0263 bll1271(mdcH) blr4082(fabD)
BRA: BRADO3310(fabD)
BBT: BBta_3817(fabD)
RPA: RPA3075(fabD)
RPB: RPB_2466
RPC: RPC_2298 RPC_4587
RPD: RPD_2983
RPE: RPE_3307
RPT: Rpal_3485
NWI: Nwi_1690
NHA: Nham_2354
OCA: OCAR_6370(fabD) OCAR_6866
BHE: BH05340(fabD)
BQU: BQ04520(fabD)
BBK: BARBAKC583_0496(fabD)
BTR: Btr_0816(fabD)
BGR: Bgr_06170(fabD)
XAU: Xaut_3116
AZC: AZC_4312
MEX: Mext_0030 Mext_0556
MEA: Mex_1p0029 Mex_1p0376(fabD)
MDI: METDI0030 METDI0527(fabD)
MRD: Mrad2831_0172 Mrad2831_1896
MET: M446_3200 M446_6851
MPO: Mpop_0052 Mpop_0527
MCH: Mchl_0031 Mchl_0491
MNO: Mnod_2787 Mnod_3157
BID: Bind_2300
MSL: Msil_0896 Msil_3186
CCR: CC_1674
CCS: CCNA_01746
CAK: Caul_2517
PZU: PHZ_c1557(fabD)
SIL: SPO2276(fabD)
SIT: TM1040_1050
RSP: RSP_2682(fabD)
RSH: Rsph17029_1340
RSQ: Rsph17025_1221
RSK: RSKD131_0997
JAN: Jann_1624
RDE: RD1_2925(fabD) RD1_3040(fabD)
PDE: Pden_1770
DSH: Dshi_2183(fabD)
MMR: Mmar10_1213
HNE: HNE_2160(fabD)
HBA: Hbal_1940
ZMO: ZMO1223
ZMN: Za10_0110
NAR: Saro_1427
SAL: Sala_1897
SWI: Swit_0086 Swit_4292
ELI: ELI_07340
GOX: GOX2039
GBE: GbCGDNIH1_2212
ACR: Acry_1525
GDI: GDI_2944(fabD)
GDJ: Gdia_3405
APT: APA01_11760
RRU: Rru_A0415
RCE: RC1_1572(fabD)
MAG: amb2105
MGM: Mmc1_1875
BSU: BSU15900(fabD)
BHA: BH2492(fabD)
BAN: BA3990(fabD)
BAR: GBAA3990(fabD)
BAA: BA_4461
BAT: BAS3703
BAH: BAMEG_0641(fabD)
BAI: BAA_4014(fabD)
BCE: BC3850
BCA: BCE_3894(fabD)
BCZ: BCZK3611(fabD)
BCR: BCAH187_A3900(fabD)
BCB: BCB4264_A3951(fabD)
BCU: BCAH820_3866(fabD)
BCG: BCG9842_B1292(fabD)
BCQ: BCQ_3637(fabD)
BCX: BCA_3952(fabD)
BCY: Bcer98_2504
BTK: BT9727_3593(fabD)
BTL: BALH_3483
BWE: BcerKBAB4_3675
BLI: BL02314(fabD)
BLD: BLi01811(fabD)
BCL: ABC2302(fabD)
BAY: RBAM_015730(fabD) RBAM_016910(baeC)
BPU: BPUM_1489(fabD)
OIH: OB1523(fabD)
GKA: GK1189
GTN: GTNG_1042(fabD)
GWC: GWCH70_1080
GYM: GYMC10_4245
GYC: GYMC61_1971
AFL: Aflv_1773(fabD)
SAU: SA1073(fabD)
SAV: SAV1230(fabD)
SAW: SAHV_1220(fabD)
SAM: MW1113(fabD)
SAR: SAR1206(fabD)
SAS: SAS1164
SAC: SACOL1244(fabD)
SAB: SAB1094(fabD)
SAA: SAUSA300_1123(fabD)
SAX: USA300HOU_1166(fabD)
SAO: SAOUHSC_01198
SAJ: SaurJH9_1289
SAH: SaurJH1_1314
SAE: NWMN_1140(fabD)
SAD: SAAV_1202(fabD)
SEP: SE0905
SER: SERP0796(fabD)
SHA: SH1684(fabD)
SSP: SSP1539
SCA: Sca_0853(fabD)
LMO: lmo1808(fabD)
LMF: LMOf2365_1836(fabD)
LMH: LMHCC_0749(fabD)
LMC: Lm4b_01824(fabD)
LIN: lin1922
LWE: lwe1827(fabD)
LSP: Bsph_1517
ESI: Exig_1909
EAT: EAT1b_2884
MCL: MCCL_0815(fabD)
BBE: BBR47_36260(fabD)
PJD: Pjdr2_3492
AAC: Aaci_1343
LLA: L0184(fabD)
LLK: LLKF_0793(fabD)
LLC: LACR_0823
LLM: llmg_1785(fabD)
SPY: SPy_1750(fabD)
SPZ: M5005_Spy_1491(fabD)
SPM: spyM18_1822
SPG: SpyM3_1524(fabD)
SPS: SPs0342
SPH: MGAS10270_Spy1559(fabD)
SPI: MGAS10750_Spy1550(fabD)
SPJ: MGAS2096_Spy1519(fabD)
SPK: MGAS9429_Spy1493(fabD)
SPF: SpyM50354(fabD)
SPA: M6_Spy1485
SPB: M28_Spy1480(fabD)
SOZ: Spy49_1366c(fabD)
SPN: SP_0420
SPD: SPD_0383(fabD)
SPR: spr0380(fabD)
SPW: SPCG_0418(fabD)
SPX: SPG_0386(fabD)
SNE: SPN23F_03950(fabD)
SPV: SPH_0528(fabD)
SNM: SP70585_0491(fabD)
SJJ: SPJ_0406(fabD)
SPP: SPP_0451(fabD)
SNT: SPT_0457(fabD)
SAG: SAG0347(fabD)
SAN: gbs0334
SAK: SAK_0421(fabD)
SMU: SMU.1741(fabD)
STC: str0386(fabD)
STL: stu0386(fabD)
STE: STER_0432
SSA: SSA_1937(fabD)
SSU: SSU05_1804
SSV: SSU98_1808
SSB: SSUBM407_1677(fabD)
SSI: SSU1604(fabD)
SSS: SSUSC84_1629(fabD)
SGO: SGO_1694(fabD)
SEQ: SZO_15710
SEZ: Sez_0409(fabD)
SEU: SEQ_0481
SUB: SUB1497(fabD)
SDS: SDEG_1819(fabD)
LPL: lp_1673(fabD)
LPJ: JDM1_1406(fabD)
LSA: LSA0815(fabD)
LSL: LSL_0453(fabD)
LDB: Ldb0902(fabD)
LBU: LBUL_0820
LBR: LVIS_0933
LCA: LSEI_2116
LCB: LCABL_22970(fabD)
LRE: Lreu_0989
LRF: LAR_0925
LHE: lhv_1930
LFE: LAF_0312
LRH: LGG_02117
LRL: LC705_02113
PPE: PEPE_0857
EFA: EF2882(fabD)
OOE: OEOE_1590
LME: LEUM_0312
LCI: LCK_00304(fabD)
CAC: CAC3575(fabD)
CPE: CPE1069(fabD)
CPF: CPF_1325(fabD)
CPR: CPR_1137(fabD)
CTC: CTC00129
CNO: NT01CX_0924(fabD)
CTH: Cthe_0935
CDF: CD1181(fabD)
CDC: CD196_1041(fabD)
CDL: CDR20291_1019(fabD)
CBO: CBO3601(fabD)
CBA: CLB_3681(fabD)
CBH: CLC_3579(fabD)
CBY: CLM_4093(fabD)
CBL: CLK_3074(fabD)
CBK: CLL_A1149(fabD)
CBB: CLD_0885(fabD)
CBI: CLJ_B3930(fabD)
CBT: CLH_1083(fabD)
CBF: CLI_3826(fabD)
CBE: Cbei_1070
CKL: CKL_0105(fabD)
CKR: CKR_0081
CPY: Cphy_0516
CCE: Ccel_0683 Ccel_0975
AMT: Amet_2756
AOE: Clos_1454
STH: STH1450
SWO: Swol_1851
VPR: Vpar_0698
ATE: Athe_1155
DSY: DSY2661
DHD: Dhaf_3818
DRM: Dred_2073
DAE: Dtox_1179
PTH: PTH_1743(fabD)
DAU: Daud_0641
HMO: HM1_2164(fabD)
EEL: EUBELI_20278
ERE: EUBREC_3146
TTE: TTE1473(fabD)
TEX: Teth514_1724
TPD: Teth39_1288
CHY: CHY_1448(fabD)
MTA: Moth_0947
ADG: Adeg_0957
CSC: Csac_1604
CPO: COPRO5265_0256 COPRO5265_0257
NTH: Nther_1359
HOR: Hore_10280
ACL: ACL_0462(fabD)
MTU: Rv0649(fabD2) Rv2243(fabD)
MTC: MT0677 MT2303(fabD)
MRA: MRA_0660(fabD2) MRA_2263(fabD)
MTF: TBFG_10662 TBFG_12272
MTB: TBMG_00660(TBMG_00660.1) TBMG_01737(TBMG_01737.1)
MBO: Mb0668(fabD2) Mb2267(fabD)
MBB: BCG_0698(fabD2) BCG_2260(fabD)
MBT: JTY_0668(fabD2) JTY_2254(fabD)
MLE: ML1653(fabD)
MLB: MLBr_01653(fabD)
MPA: MAP1996(fabD) MAP4122(fabD2)
MAV: MAV_2194 MAV_4511
MSM: MSMEG_1362 MSMEG_4325 MSMEG_6629(mdcH)
MUL: MUL_0738(fabD2) MUL_1306(fabD)
MVA: Mvan_1250 Mvan_3754
MGI: Mflv_2779 Mflv_5103
MAB: MAB_1879c
MMC: Mmcs_0964 Mmcs_3364
MKM: Mkms_0982 Mkms_3426
MJL: Mjls_0992 Mjls_3375
MMI: MMAR_0986(fabD2) MMAR_3336(fabD)
CGT: cgR_0352
NFA: nfa16150(fabD)
RHA: RHA1_ro01199(fabD)
RER: RER_36720(fabD)
ROP: ROP_09220(fabD)
GBR: Gbro_3121
SCO: SCO2387(fabD)
SMA: SAV_5788(fabD)
SGR: SGR_3283 SGR_5108(fabD) SGR_6780
TWH: TWT254(fabD)
TWS: TW516(fabD)
LXX: Lxx12720(fabD)
CMI: CMM_1619(fabD)
CMS: CMS_1602(fabD)
ART: Arth_2466
AAU: AAur_2330 AAur_2435
ACH: Achl_2205
RSA: RSal33209_1102
KRH: KRH_10790(fabD)
MLU: Mlut_09320
BCV: Bcav_1807
BFA: Bfae_16740
JDE: Jden_1515
KSE: Ksed_12030
XCE: Xcel_2135
PAC: PPA0984
NCA: Noca_1990
TFU: Tfu_1973
TCU: Tcur_0221 Tcur_1641
SRO: Sros_4997 Sros_7054
FRA: Francci3_3481
FRE: Franean1_1265
FAL: FRAAL5668
ACE: Acel_0878
NML: Namu_2041
KRA: Krad_3343
SEN: SACE_1526(fabD)
SVI: Svir_10290 Svir_29740
AMI: Amir_1327
STP: Strop_1192 Strop_3378
SAQ: Sare_1085 Sare_3620
CAI: Caci_6809
RXY: Rxyl_1379 Rxyl_3058
CCU: Ccur_11140
SHI: Shel_01060
ELE: Elen_1988
CTR: CT238(fabD)
CTA: CTA_0260(fabD)
CTB: CTL0490(fabD)
CTL: CTLon_0486(fabD)
CTJ: JALI_2331(fabD)
CMU: TC0509(fabD)
CPN: CPn0297(fabD)
CPA: CP0461
CPJ: CPj0297(fabD)
CPT: CpB0306(fabD)
CCA: CCA00485(fabD)
CAB: CAB471(fabD)
CFE: CF0522(fabD)
PCU: pc1719(fabD)
TDE: TDE0601
BHY: BHWA1_00189(fabD)
ABA: Acid345_4573
ACA: ACP_1923(fabD)
SUS: Acid_2598
BTH: BT_0789
BFR: BF2258
BFS: BF2352(fabD)
BVU: BVU_3989
PGI: PG0138(fabD)
PGN: PGN_0251
PDI: BDI_1760
APS: CFPG_721
SRU: SRU_0043(fabD)
RMR: Rmar_2802
CHU: CHU_2469(fabD)
DFE: Dfer_3966
CPI: Cpin_6954
PHE: Phep_4148
GFO: GFO_0276(fabD)
FJO: Fjoh_1730
FPS: FP0408(fabD)
FBA: FIC_02309
COC: Coch_1499
RBI: RB2501_03430
BBL: BLBBGE_538(fabD)
BPI: BPLAN_103(fabD)
AAS: Aasi_0199
FSU: Fisuc_2804
FNU: FN0149
LBA: Lebu_0619
STR: Sterm_2464
OTE: Oter_3194
MIN: Minf_0433(fabD)
AMU: Amuc_1507
GAU: GAU_1638(fabD)
RBA: RB314(fabD)
RSD: TGRD_603
TAI: Taci_1098
SYN: slr2023(fabD)
SYW: SYNW2249(fabD)
SYC: syc0101_c
SYF: Synpcc7942_1456
SYD: Syncc9605_2387
SYE: Syncc9902_0305
SYG: sync_2600(fabD)
SYR: SynRCC307_0247(fabD)
SYX: SynWH7803_2251(fabD)
SYP: SYNPCC7002_A2559(fabD)
CYA: CYA_2365(fabD)
CYB: CYB_2339(fabD)
TEL: tlr0041(fabD)
MAR: MAE_19460(fabD)
CYT: cce_1583(fabD)
CYP: PCC8801_1804
CYC: PCC7424_1044
CYN: Cyan7425_3992
CYH: Cyan8802_1832
GVI: gll2145
ANA: alr0240
NPU: Npun_F0100
AVA: Ava_2730
PMA: Pro0159(fabD)
PMM: PMM0137(fabD)
PMT: PMT1997(fabD)
PMN: PMN2A_1503
PMI: PMT9312_0139
PMB: A9601_01541(fabD)
PMC: P9515_01651(fabD)
PMF: P9303_26561(fabD)
PMG: P9301_01561(fabD)
PMH: P9215_01541(fabD)
PMJ: P9211_01511(fabD)
PME: NATL1_02091(fabD)
AMR: AM1_3514(fabD)
CTE: CT2115(fabD)
CPC: Cpar_0130
CCH: Cag_1663
CPH: Cpha266_2491
CPB: Cphamn1_0181
CLI: Clim_0168
PVI: Cvib_0199
PLT: Plut_0132
PPH: Ppha_0198
PAA: Paes_0176
CTS: Ctha_0675
DET: DET1276(fabD)
DEH: cbdb_A1204(fabD)
DEB: DehaBAV1_1087
DEV: DhcVS_1059(fabD)
RRS: RoseRS_3469
RCA: Rcas_1491
CAU: Caur_2407
CAG: Cagg_2986
CHL: Chy400_2594
HAU: Haur_0745
TRO: trd_1622(fabD) trd_A0446(fabD)
STI: Sthe_0374
DRA: DR_1945
DGE: Dgeo_0434
DDR: Deide_05710(fabD)
TTH: TTC0048
TTJ: TTHA0416
AAE: aq_892(fabD)
HYA: HY04AAS1_0740
SUL: SYO3AOP1_1158
SAF: SULAZ_1520(fabD)
PMX: PERMA_0648(fabD)
TMA: TM0798
TPT: Tpet_0130
TLE: Tlet_0430
TRQ: TRQ2_0128
TNA: CTN_1780
TNP: Tnap_0131
TME: Tmel_1589
TAF: THA_1796(fabD)
FNO: Fnod_0611
PMO: Pmob_1034
KOL: Kole_0971
DTH: DICTH_0793(fabD)
DTU: Dtur_0942
TYE: THEYE_A1586(fabD)
TTR: Tter_0013 Tter_1644
 |
|---|
| Structures |
PDB: 1NM2 2CUY 2G1H 2G2O 2G2Y 2G2Z 2H1Y 2PFF 2QC3 2QJ3
3EEN 3EZO 3G87 3H0P |
|---|
Reference
Authors
Title
Journal
|
1
Alberts, A.W., Majerus, P.W. and Vagelos, P.R.
Acetyl-CoA acyl carrier protein transacylase.
Methods Enzymol. 14 (1969) 50-53. |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:4561013]
Prescott DJ, Vagelos PR.
Acyl carrier protein.
Adv. Enzymol. Relat. Areas. Mol. Biol. 36 (1972) 269-311. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5330116]
Williamson IP, Wakil SJ.
Studies on the mechanism of fatty acid synthesis. XVII. Preparation
and general properties of acetyl coenzyme A and malonyl coenzyme
A-acyl carrier protein transacylases.
J. Biol. Chem. 241 (1966) 2326-32.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:4934182]
Joshi VC, Wakil SJ.
Studies on the mechanism of fatty acid synthesis. XXVI. Purification
and properties of malonyl-coenzyme A--acyl carrier protein
transacylase of Escherichia coli.
Arch. Biochem. Biophys. 143 (1971) 493-505.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:11373295]
Kremer L, Nampoothiri KM, Lesjean S, Dover LG, Graham S, Betts J,
Brennan PJ, Minnikin DE, Locht C, Besra GS.
Biochemical characterization of acyl carrier protein (AcpM) and
malonyl-CoA:AcpM transacylase (mtFabD), two major components of
Mycobacterium tuberculosis fatty acid synthase II.
J. Biol. Chem. 276 (2001) 27967-74.
Mycobacterium tuberculosis |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:12575934]
Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ,
O'Connell JD 3rd, Khosla C, Stroud RM.
Catalysis, specificity, and ACP docking site of Streptomyces
coelicolor malonyl-CoA:ACP transacylase.
Structure. 11 (2003) 147-54.
Streptomyces coelicolor [GN:sco] |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:11814333]
Szafranska AE, Hitchman TS, Cox RJ, Crosby J, Simpson TJ.
Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase
from Streptomyces coelicolor indicates a single catalytically
competent serine nucleophile at the active site.
Biochemistry. 41 (2002) 1421-7.
Streptomyces coelicolor [GN:sco] |
|---|
Reference
Authors
Title
Journal
Organism
|
8 [PMID:9208947]
Hoenke S, Schmid M, Dimroth P
Sequence of a gene cluster from Klebsiella pneumoniae encoding
malonate decarboxylase and expression of the enzyme in Escherichia
coli.
Eur. J. Biochem. 246 (1997) 530-8.
Klebsiella pneumoniae [GN:kpn] |
|---|
Reference
Authors
Title
Journal
Organism
|
9 [PMID:10561613]
Koo JH, Kim YS
Functional evaluation of the genes involved in malonate
decarboxylation by Acinetobacter calcoaceticus.
Eur. J. Biochem. 266 (1999) 683-90.
Acinetobacter calcoaceticus |
|---|
Reference
Authors
Title
Journal
Organism
|
10 [PMID:9914491]
Hoenke S, Dimroth P
Formation of catalytically active acetyl-S-malonate decarboxylase
requires malonyl-coenzyme A:acyl carrier protein transacylase as
auxiliary enzyme [corrected]
Eur. J. Biochem. 259 (1999) 181-7.
Klebsiella pneumoniae [GN:kpn] |
|---|
Reference
Authors
Title
Journal
Organism
|
11 [PMID:9851033]
Chohnan S, Fujio T, Takaki T, Yonekura M, Nishihara H, Takamura Y
Malonate decarboxylase of Pseudomonas putida is composed of five
subunits.
FEMS. Microbiol. Lett. 169 (1998) 37-43.
Pseudomonas putida |
|---|
Reference
Authors
Title
Journal
Organism
|
12 [PMID:11902724]
Dimroth P, Hilbi H
Enzymic and genetic basis for bacterial growth on malonate.
Mol. Microbiol. 25 (1997) 3-10.
Klebsiella pneumoniae [GN:kpn], Malonomonas rubra |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.39
IUBMB Enzyme Nomenclature: 2.3.1.39
ExPASy - ENZYME nomenclature database: 2.3.1.39
BRENDA, the Enzyme Database: 2.3.1.39
CAS: 37257-17-3 |
|---|
