| Entry |
|
|---|
| Name |
beta-ketoacyl-acyl-carrier-protein synthase I;
beta-ketoacyl-ACP synthase I;
beta-ketoacyl synthetase;
beta-ketoacyl-ACP synthetase;
beta-ketoacyl-acyl carrier protein synthetase;
beta-ketoacyl-[acyl carrier protein] synthase;
beta-ketoacylsynthase;
condensing enzyme;
3-ketoacyl-acyl carrier protein synthase;
fatty acid condensing enzyme;
acyl-malonyl(acyl-carrier-protein)-condensing enzyme;
acyl-malonyl acyl carrier protein-condensing enzyme;
beta-ketoacyl acyl carrier protein synthase;
3-oxoacyl-[acyl-carrier-protein] synthase;
3-oxoacyl:ACP synthase I;
KASI;
KAS I;
FabF1;
FabB;
acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein]
C-acyltransferase (decarboxylating) |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein]
C-acyltransferase (decarboxylating) |
|---|
| Reaction(IUBMB) |
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] =
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
[RN:R02768] |
|---|
| Reaction(KEGG) |
R02768 > R04355 R04726 R04952 R04957 R04960 R04963 R04968 R07762
 |
|---|
| Substrate |
acyl-[acyl-carrier protein] [CPD:C00173];
malonyl-[acyl-carrier protein] [CPD:C01209] |
|---|
| Product |
3-oxoacyl-[acyl-carrier protein] [CPD:C00685];
CO2 [CPD:C00011];
[acyl-carrier protein] [CPD:C00229] |
|---|
| Comment |
This enzyme is responsible for the chain-elongation step of
dissociated (type II) fatty-acid biosynthesis, i.e. the addition of
two C atoms to the fatty-acid chain. Escherichia coli mutants that
lack this enzyme are deficient in unsaturated fatty acids. The
enzyme can use fatty acyl thioesters of ACP (C2 to C16) as
substrates, as well as fatty acyl thioesters of Co-A (C4 to C16)
[4]. The substrate specificity is very similar to that of EC
2.3.1.179, beta-ketoacyl-ACP synthase II, with the exception that
the latter enzyme is far more active with palmitoleoyl-ACP
(C16Delta9) as substrate, allowing the organism to regulate its
fatty-acid composition with changes in temperature [4,5]. |
|---|
| Pathway |
PATH: ec00061 Fatty acid biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00647 3-oxoacyl-[acyl-carrier-protein] synthase I |
|---|
| Genes |
ECO: b2323(fabB)
ECJ: JW2320(fabB)
ECD: ECDH10B_2485(fabB)
EBW: BWG_2097(fabB)
ECE: Z3586(fabB) Z4863
ECS: ECs3207 ECs4338
ECF: ECH74115_3464(fabB) ECH74115_4811
ETW: ECSP_3198(fabB) ECSP_4445
ECG: E2348C_2463(fabB)
ECC: c1189 c2869(fabB)
ECI: UTI89_C2608(fabB)
ECP: ECP_2362
ECV: APECO1_4241(fabB)
ECW: EcE24377A_2618(fabB)
ECX: EcHS_A2474(fabB)
ECM: EcSMS35_2480(fabB)
ECY: ECSE_2632
ECL: EcolC_1329
ECK: EC55989_2567(fabB)
ECQ: ECED1_2787(fabB)
ECR: ECIAI1_2400(fabB)
ECT: ECIAI39_2472(fabB)
ECZ: ECS88_2471(fabB)
EUM: ECUMN_2663(fabB) ECUMN_3952
ELF: LF82_0605(fabB)
EBL: B21_02208(fabB)
EBD: ECBD_1336
EBR: ECB_02248(fabB)
EOH: ECO103_2787(fabB)
EOI: ECO111_3071(fabB)
EOJ: ECO26_3311(fabB)
EFE: EFER_0840(fabB) EFER_3463
STY: STY2609(fabB)
STT: t0486(fabB)
SPT: SPA0486(fabB)
SEK: SSPA0450
SPQ: SPAB_00592
SEI: SPC_1327(fabB)
SEC: SC2380(fabB)
SEH: SeHA_C2620
SEE: SNSL254_A2567
SEW: SeSA_A2607
SEA: SeAg_B2518
SED: SeD_A2731
SEG: SG2408(fabB)
SET: SEN2360(fabB)
SES: SARI_00522
STM: STM2378(fabB)
YPE: YPO1455 YPO2757(fabB)
YPK: y1591(fabB) y2714(fabF)
YPM: YP_1347(fabF3) YP_2406(fabB)
YPA: YPA_0748 YPA_2086
YPN: YPN_2189 YPN_2523
YPG: YpAngola_A0371(fabB) YpAngola_A2967
YPP: YPDSF_1519 YPDSF_2003
YPS: YPTB1473 YPTB2626(fabB)
YPI: YpsIP31758_1411(fabB) YpsIP31758_2520
YPY: YPK_1520 YPK_2610
YPB: YPTS_1580 YPTS_2721
YEN: YE0908 YE1287(fabB)
SFL: SF2399(fabB)
SFX: S2534(fabB)
SFV: SFV_2392(fabB)
SSN: SSON_2381(fabB)
SBO: SBO_2360(fabB)
SBC: SbBS512_E2701(fabB)
SDY: SDY_2522(fabB)
ECA: ECA3063(fabB) ECA4494
PCT: PC1_2805
PWA: Pecwa_1459 Pecwa_4579
ETA: ETA_11600(fabB)
PLU: plu3184(fabB)
PAY: PAU_01438(fabB)
BUC: BU092(fabB)
BAS: BUsg084(fabB)
BAB: bbp086(fabB)
BCC: BCc_056(fabB)
BAP: BUAP5A_090(fabB)
BAU: BUAPTUC7_091(fabB)
WBR: WGLp408(fabB)
SGL: SG1623
ENT: Ent638_2871 Ent638_3896
ESA: ESA_00893
CTU: Ctu_29510(fabB) Ctu_40010
KPN: KPN_02713(fabB)
KPE: KPK_1426(fabB)
KPU: KP1_3963(fabB)
CKO: CKO_00462 CKO_04921
SPE: Spro_0900 Spro_3368
PMR: PMI0754 PMI1795(fabB)
EIC: NT01EI_2727
ETR: ETAE_0826 ETAE_2421
BFL: Bfl498(fabB)
BPN: BPEN_514(fabB)
HDE: HDEF_0092(fabB)
DDA: Dd703_2585
DDC: Dd586_2782 Dd586_4178
DZE: Dd1591_1359
HIN: HI1533(fabB)
HIT: NTHI1600(fabB)
HIP: CGSHiEE_05245
HIQ: CGSHiGG_00290
HDU: HD0612(fabB)
HAP: HAPS_2156(fabB)
HSO: HS_0105(fabF) HS_0665(fabB)
HSM: HSM_1005 HSM_1990
PMU: PM0339(fabB)
MSU: MS1591(fabB)
APL: APL_1055(fabB)
APJ: APJL_1073(fabB)
APA: APP7_1112
ASU: Asuc_0888
AAP: NT05HA_1266 NT05HA_1715
AAT: D11S_0528 D11S_0844
XFA: XF1639
XFT: PD1142(fabB)
XFM: Xfasm12_1245
XFN: XfasM23_1215
XCC: XCC0581(fabB) XCC3998(fabF)
XCB: XC_3652 XC_4087
XCA: xccb100_3769(fabB) xccb100_4190(fabF2)
XCV: XCV3742(fabB) XCV4172(fabF)
XAC: XAC3625(fabB) XAC4086(fabF)
XOO: XOO0463(fabF) XOO0761(fabB)
XOM: XOO_0427 XOO_0691
XOP: PXO_02883 PXO_03137
SML: Smlt0576(fabB) Smlt4559
SMT: Smal_0453 Smal_3911
VCO: VC0395_A1693(fabB)
VCM: VCM66_2032(fabB)
VCJ: VCD_002260
VVU: VV1_0058 VV1_1986
VVY: VV1069 VV2429
VPA: VP0884 VP2194
VHA: VIBHAR_03105
VSP: VS_0773 VS_0898
VEX: VEA_002870 VEA_004075
VFI: VF_0857 VF_1700(fabB)
VFM: VFMJ11_0895 VFMJ11_1826
VSA: VSAL_I1071(fabB) VSAL_I2092
PPR: PBPRA2658 PBPRB0107
PAE: PA0098 PA1609(fabB)
PAU: PA14_01190 PA14_43690(fabB)
PAP: PSPA7_0172 PSPA7_3665(fabB)
PAG: PLES_00991 PLES_37181(fabB)
PPU: PP_4175(fabB)
PPF: Pput_1693
PPG: PputGB1_3746
PPW: PputW619_3498
PST: PSPTO_2210(fabB) PSPTO_5107
PSB: Psyr_0425 Psyr_2019
PSP: PSPPH_0415 PSPPH_1989(fabB)
PFL: PFL_0464(fabF-2) PFL_1736 PFL_3001
PFO: Pfl01_0425 Pfl01_4213
PFS: PFLU0423 PFLU1835(fabB)
PEN: PSEEN0348 PSEEN3623(fabB)
PMY: Pmen_2335 Pmen_2470
PSA: PST_1892(fabB)
CJA: CJA_0097 CJA_0749(fabB)
AVN: Avin_29060(fabB)
PAR: Psyc_1899(fabB)
PCR: Pcryo_2189
ACI: ACIAD0580 ACIAD0879(fabB)
ACB: A1S_0080 A1S_0522 A1S_0863
ABM: ABSDF2572(fabB)
ABY: ABAYE2951(fabB)
ABC: ACICU_00109 ACICU_00531 ACICU_00813
ABN: AB57_0909
ABB: ABBFA_002751
SON: SO_3072(fabB) SO_4380
SDN: Sden_1482
SFR: Sfri_0340 Sfri_1391
SAZ: Sama_2154 Sama_3391
SBL: Sbal_0330 Sbal_2746
SBM: Shew185_0328 Shew185_2763
SBN: Sbal195_0335 Sbal195_2840
SBP: Sbal223_0338 Sbal223_1613
SLO: Shew_2410 Shew_3523
SPC: Sputcn32_0434 Sputcn32_2445
SSE: Ssed_0313 Ssed_1644
SPL: Spea_1606 Spea_3900
SHE: Shewmr4_0338 Shewmr4_1422
SHM: Shewmr7_1487 Shewmr7_3688
SHN: Shewana3_0329 Shewana3_1475
SHW: Sputw3181_0288 Sputw3181_1563
SHL: Shal_0369 Shal_2654
SWD: Swoo_3008 Swoo_4609
SWP: swp_0292 swp_3121
ILO: IL0140 IL1021(fabB)
CPS: CPS_3807(fabB)
PHA: PSHAa2080(fabB) PSHAb0407
PAT: Patl_3383
SDE: Sde_0998
MAQ: Maqu_3148
AMC: MADE_01194
PIN: Ping_1995
TTU: TERTU_0947 TERTU_3272 TERTU_4608
LPN: lpg0102(fabF) lpg0361(fabF) lpg0362(fabF)
LPF: lpl0102(fabF) lpl0402 lpl0403
LPP: lpp0116(fabF) lpp0426 lpp0427
LPC: LPC_0121(fabF) LPC_2982(fabFn) LPC_2983(fabFc)
MCA: MCA0924 MCA2879(fabB)
FPH: Fphi_1090
TCX: Tcr_1945
NOC: Noc_1777
AEH: Mlg_1373
HHA: Hhal_0018
HNA: Hneap_0983 Hneap_2239
HCH: HCH_06402
CSA: Csal_0456 Csal_2758
ABO: ABO_0834(fabB)
MMW: Mmwyl1_3885 Mmwyl1_4242
AHA: AHA_1920(fabB) AHA_3385
ASA: ASA_0922(fabF) ASA_2365(fabB)
TAU: Tola_1573
DNO: DNO_0315(fabB)
AFE: Lferr_0939
AFR: AFE_0796
BCI: BCI_0362(fabB)
RMA: Rmag_1004
VOK: COSY_0900(fabB)
KKO: Kkor_2091 Kkor_2586
RSO: RS00773(RSp0361) RSc0427 RSp0357(fabB)
RPI: Rpic_0303 Rpic_4771 Rpic_4775
RPF: Rpic12D_0315 Rpic12D_3694 Rpic12D_3698
REU: Reut_B3927
REH: H16_B1667(fabB)
RME: Rmet_4389
CTI: RALTA_B1477
BVI: Bcep1808_2871 Bcep1808_5964 Bcep1808_5968
BUR: Bcep18194_A6096
BCN: Bcen_2152
BCH: Bcen2424_2766
BCJ: BCAL0838
BAM: Bamb_2818 Bamb_3608 Bamb_3612
BAC: BamMC406_2685 BamMC406_4083 BamMC406_4087
BXE: Bxe_A0937 Bxe_A0941
BPH: Bphy_0700 Bphy_0704
BPY: Bphyt_3050 Bphyt_3054
BPT: Bpet4436
RFR: Rfer_3977 Rfer_3984
PNA: Pnap_1371
AAV: Aave_3482 Aave_4180
AJS: Ajs_0526
VEI: Veis_2160
DAC: Daci_1274
DIA: Dtpsy_0542
VAP: Vapar_0262 Vapar_0539 Vapar_3383
CTT: CtCNB1_4240
MPT: Mpe_A1324
HAR: HEAR2876
EBA: ebA7072(fabF1)
AZO: azo0284 azo3911(fabF2)
DAR: Daro_2374 Daro_4185
TBD: Tbd_2753
MFA: Mfla_1893
MMB: Mmol_1539
MEI: Msip34_0872
APP: CAP2UW1_0368
CCV: CCV52592_1166
CCO: CCC13826_2166(norM)
SDL: Sdel_2110 Sdel_2123
GSU: GSU3168 GSU3181
GME: Gmet_0287
PCA: Pcar_2650 Pcar_2666(fabB)
DVU: DVU2563
DVL: Dvul_0685
DDE: Dde_2660
DSA: Desal_0523 Desal_0540
DPS: DP1840 DP1849
SCL: sce1201 sce8358
SAT: SYN_02566
SFU: Sfum_2631
PUB: SAR11_0396(fabB)
MLO: mll5566 mlr2352
MES: Meso_3938
PLA: Plav_1499 Plav_3635
SME: SMc00327(fabB)
SMD: Smed_3449
ATU: Atu0150(fabB)
ATC: AGR_C_244
ARA: Arad_0159(fabB)
AVI: Avi_0180(fabB)
RET: RHE_CH00108(fabB)
REC: RHECIAT_CH0000144(fabB) RHECIAT_PC0000953
RLE: RL0117(fabB)
RLT: Rleg2_4057
RLG: Rleg_4379
RHI: NGR_c35760(fabB)
LAS: CLIBASIA_01730(fabB)
BME: BMEI1957
BMF: BAB1_2173(fabB)
BMB: BruAb1_2145(fabB)
BMC: BAbS19_I20340
BMS: BR2172(fabB)
BMT: BSUIS_A2009
BOV: BOV_2084(fabB)
BCS: BCAN_A2214
BMR: BMI_I2193(fabB)
OAN: Oant_0740
BJA: blr0770(fabB)
BRA: BRADO0062(fabB)
BBT: BBta_0068(fabB)
RPA: RPA0426(fabB)
RPB: RPB_0612
RPC: RPC_0348
RPD: RPD_0221
RPE: RPE_0256
RPT: Rpal_0430
NWI: Nwi_0033
NHA: Nham_0041
OCA: OCAR_4498
BHE: BH01280(fabB)
BQU: BQ01210(fabB)
BBK: BARBAKC583_1269
BTR: Btr_0142(fabB)
BGR: Bgr_01280(fabB)
XAU: Xaut_0053
AZC: AZC_4643
MEX: Mext_0425
MEA: Mex_1p0340(fabB)
MDI: METDI0495(fabB)
MRD: Mrad2831_2684
MET: M446_2228
MPO: Mpop_0495
MCH: Mchl_0458
MNO: Mnod_0383
BID: Bind_0332
MSL: Msil_2205
CCR: CC_3719
CCS: CCNA_03835
CAK: Caul_5061
PZU: PHZ_c0028(fabB)
SIL: SPOA0440(fabB)
SIT: TM1040_0181
RSP: RSP_3177(fabB) RSP_3468
RSH: Rsph17029_3113 Rsph17029_3914
RSQ: Rsph17025_3935
RSK: RSKD131_3351 RSKD131_3634
JAN: Jann_1656
RDE: RD1_3924(fabB)
PDE: Pden_1650
DSH: Dshi_1009(fabB)
MMR: Mmar10_3059
HBA: Hbal_1299 Hbal_3056
ELI: ELI_06740
GOX: GOX1396
GBE: GbCGDNIH1_0031
BHY: BHWA1_00292(fabB)
BVU: BVU_1012 BVU_1020
CHU: CHU_2115(fabG) CHU_2863(fabF)
DFE: Dfer_1989 Dfer_1992 Dfer_1997
CPI: Cpin_1855 Cpin_6844
GFO: GFO_1660
FJO: Fjoh_1088 Fjoh_1106
FPS: FP2265 FP2284(fabB)
COC: Coch_0739 Coch_0745 Coch_0847
FSU: Fisuc_3002
OTE: Oter_4015
 |
|---|
| Structures |
PDB: 1B3N 1DD8 1E5M 1EBL 1EK4 1F91 1FJ4 1FJ8 1G5X 1H4F
1HN9 1HND 1HNH 1HNJ 1HNK 1HZP 1J3N 1KAS 1M1M 1MZJ
1MZS 1OX0 1OXH 1TQY 1U6E 1U6S 1UB7 1W0I 1ZOW 2AHB
2AJ9 2ALM 2AQ7 2AQB 2BUH 2BUI 2BYW 2BYX 2BYY 2BYZ
2BZ3 2BZ4 2C9H 2EBD 2EFT 2GFV 2GFW 2GFX 2GFY 2GP6
2GQD 2GYO 2IWY 2IWZ 2IX4 2PFF 2QNX 2QNY 2QNZ 2QO0
2QO1 2QX1 2RJT 2VB7 2VB8 2VB9 2VBA 2VKZ 2WAS 2WAT
2WGD 2WGE 2WGF 2WGG 3FK5 3KZU 3LED |
|---|
Reference
Authors
Title
Journal
|
1
Alberts, A.W., Majerus, P.W. and Vagelos, P.R.
Acetyl-CoA acyl carrier protein transacylase.
Methods Enzymol. 14 (1969) 50-53. |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:4561013]
Prescott DJ, Vagelos PR.
Acyl carrier protein.
Adv. Enzymol. Relat. Areas. Mol. Biol. 36 (1972) 269-311. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5327099]
Toomey RE, Wakil SJ.
Studies on the mechanism of fatty acid synthesis. XVI. Preparation
and general properties of acyl-malonyl acyl carrier
protein-condensing enzyme from Escherichia coli.
J. Biol. Chem. 241 (1966) 1159-65.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:237914]
D'Agnolo G, Rosenfeld IS, Vagelos PR.
Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in
Escherichia coli.
J. Biol. Chem. 250 (1975) 5289-94.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:7002930]
Garwin JL, Klages AL, Cronan JE Jr.
Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl
carrier protein synthases I and II of Escherichia coli.
J. Biol. Chem. 255 (1980) 11949-56.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:15194690]
Wang H, Cronan JE.
Functional replacement of the FabA and FabB proteins of Escherichia
coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF
homologues.
J. Biol. Chem. 279 (2004) 34489-95.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
|
7
Cronan, J.E., Jr. and Rock, C.O.
Biosynthesis of membrane lipids.
In: Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular
and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC,
1996, p. 612-636. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.41
IUBMB Enzyme Nomenclature: 2.3.1.41
ExPASy - ENZYME nomenclature database: 2.3.1.41
BRENDA, the Enzyme Database: 2.3.1.41
CAS: 9077-10-5 |
|---|
