KEGG   ENZYME: 2.3.1.43Help
Entry
EC 2.3.1.43                 Enzyme                                 
Name
phosphatidylcholine---sterol O-acyltransferase;
lecithin---cholesterol acyltransferase;
phospholipid---cholesterol acyltransferase;
LCAT (lecithin-cholesterol acyltransferase);
lecithin:cholesterol acyltransferase;
lysolecithin acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
phosphatidylcholine:sterol O-acyltransferase
Reaction(IUBMB)
phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester [RN:R02114]
Reaction(KEGG)
Substrate
phosphatidylcholine [CPD:C00157];
sterol [CPD:C00370]
Product
1-acylglycerophosphocholine [CPD:C04230];
sterol ester [CPD:C01958]
Comment
Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase.
Pathway
Glycerophospholipid metabolism
Orthology
K00650  
lecithin-cholesterol acyltransferase
Genes
HSA: 
3931(LCAT)
PTR: 
743056(LCAT)
PPS: 
100976085(LCAT)
MCC: 
MMU: 
16816(Lcat)
RNO: 
24530(Lcat)
CFA: 
479680(LCAT)
AML: 
100469078(LCAT)
FCA: 
101083225(LCAT)
BTA: 
510960(LCAT)
SSC: 
100303723(LCAT)
ECB: 
100053753(LCAT)
MDO: 
100021772
SHR: 
100916426(LCAT)
OAA: 
100073500
GGA: 
396136(LCAT)
MGP: 
100539055
TGU: 
100226110
XLA: 
447501(lcat)
XTR: 
448241(lcat)
DRE: 
793137
TRU: 
101068878
OLA: 
101172491
EHI: 
EHI_031360(63.t00024) EHI_136400(33.t00023)
PFA: 
PFF1420w
PYO: 
PY04170
PKN: 
PKH_111960
TVA: 
TVAG_039060 TVAG_360450
 » show all
Taxonomy
Reference
1
  Authors
Bartlett, K., Keat, M.J. and Mercer, E.I.
  Title
Biosynthesis of sterol esters in Phycomyces blakesleeanus.
  Journal
Phytochemistry 13 (1974) 1107-1113.
Reference
2  [PMID:7061477]
  Authors
Buckley JT, Halasa LN, MacIntyre S.
  Title
Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase.
  Journal
J. Biol. Chem. 257 (1982) 3320-5.
  Organism
Aeromonas salmonicida [GN:asa]
Reference
3  [PMID:4868699]
  Authors
Glomset JA.
  Title
The plasma lecithins:cholesterol acyltransferase reaction.
  Journal
J. Lipid. Res. 9 (1968) 155-67.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno]
Reference
4  [PMID:4877146]
  Authors
Vahouny GV, Treadwell CR.
  Title
Enzymatic synthesis and hydrolysis of cholesterol esters.
  Journal
Methods. Biochem. Anal. 16 (1968) 219-72.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-14-5
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