KEGG   ENZYME: 2.3.1.5Help
Entry
EC 2.3.1.5                  Enzyme                                 
Name
arylamine N-acetyltransferase;
arylamine acetylase;
beta-naphthylamine N-acetyltransferase;
4-aminobiphenyl N-acetyltransferase;
acetyl CoA-arylamine N-acetyltransferase;
2-naphthylamine N-acetyltransferase;
arylamine acetyltransferase;
indoleamine N-acetyltransferase;
N-acetyltransferase (ambiguous);
p-aminosalicylate N-acetyltransferase;
serotonin acetyltransferase;
serotonin N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:arylamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine [RN:R02387]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
arylamine [CPD:C00292]
Product
CoA [CPD:C00010];
N-acetylarylamine [CPD:C07565]
Comment
Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA.
Pathway
Caffeine metabolism
Nitrotoluene degradation
Drug metabolism - other enzymes
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K00622  
arylamine N-acetyltransferase
Genes
HSA: 
10(NAT2) 9(NAT1)
PTR: 
464023(NAT1) 464024(NAT2)
PPS: 
100990661(NAT2) 100991667(NAT1)
GGO: 
101150362(NAT1) 101152545(NAT2)
PON: 
MCC: 
704019(NAT1) 704357(NAT2)
MMU: 
17960(Nat1) 17961(Nat2) 17962(Nat3)
RNO: 
116631(Nat1) 116632(Nat2) 290681(Nat3)
AML: 
FCA: 
101095575(NAT1)
BTA: 
512603(NAT1)
SSC: 
100511905
ECB: 
100049837
MDO: 
100027666
SHR: 
100919466
OAA: 
100077007
GGA: 
396283(PNAT10) 396537(NAT) 415809(PNAT3)
MGP: 
100548608 100548761 100549991
TGU: 
100218405(nat4) 100222183 100222522(NAT2) 100225095(NAT1)
ACS: 
100565208
DRE: 
449801 794381
OLA: 
101157683 101165718
DPP: 
DICPUDRAFT_149795
MTU: 
Rv3566c(nat)
MTV: 
RVBD_3566c
MTC: 
MT3671(nhoA)
MRA: 
MRA_3605(nat)
MTF: 
TBFG_13599
MTB: 
TBMG_03605
MTK: 
TBSG_03632
MTZ: 
TBXG_003580
MTG: 
MRGA327_22015
MTI: 
MRGA423_22535
MTE: 
CCDC5079_3307
MTL: 
CCDC5180_3259
MTO: 
MTCTRI2_3630(nat)
MTD: 
UDA_3566c(nat)
MTN: 
ERDMAN_3911(nat)
MTJ: 
J112_19200
MTUB: 
MT7199_3628
MBO: 
Mb3596c(nat)
MBB: 
BCG_3630c(nat)
MBT: 
JTY_3631(nat)
MBM: 
BCGMEX_3628c(nat)
MBK: 
K60_037040
MAF: 
MAF_35780(nat)
MCE: 
MCAN_35771(nat)
MCQ: 
BN44_110058(nat)
MCV: 
BN43_90064(nat)
MCX: 
BN42_90063(nat)
MCZ: 
BN45_100065(nat)
MPA: 
MAP0501(nhoA)
MAV: 
MAV_0595
MIT: 
OCO_05040
MIR: 
OCQ_05190
MIA: 
OCU_05080
MID: 
MIP_00946
MSM: 
MSMEG_0306
MSG: 
MSMEI_0299(nat)
MSA: 
Mycsm_00165
MUL: 
MUL_4131(nat)
MVA: 
Mvan_0235
MGI: 
Mflv_0433
MSP: 
Mspyr1_03210
MMC: 
Mmcs_0211
MKM: 
Mkms_0221
MJL: 
Mjls_0201
MJD: 
JDM601_0190(nat)
MMI: 
MMAR_5055(nat)
MRH: 
MycrhN_1510
MMM: 
W7S_02460
MLI: 
MULP_05313(nat)
 » show all
Taxonomy
Reference
1  [PMID:12980945]
  Authors
CHOU TC, LIPMANN F.
  Title
Separation of acetyl transfer enzymes in pigeon liver extract.
  Journal
J. Biol. Chem. 196 (1952) 89-103.
  Organism
pigeon
Reference
2  [PMID:4748369]
  Authors
Paul RC, Ratledge C.
  Title
Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes.
  Journal
Biochim. Biophys. Acta. 320 (1973) 9-15.
  Organism
Klebsiella pneumoniae [GN:kpn]
Reference
3  [PMID:13084583]
  Authors
TABOR H, MEHLER AH, STADTMAN ER.
  Title
The enzymatic acetylation of amines.
  Journal
J. Biol. Chem. 204 (1953) 127-38.
  Organism
pigeon
Reference
4  [PMID:14005907]
  Authors
WEISSBACH H, REDFIELD BG, AXELROD J.
  Title
The exzymic acetylation of serotonin and other naturally occurring amines.
  Journal
Biochim. Biophys. Acta. 54 (1961) 190-2.
  Organism
Rattus norvegicus [GN:rno], Bos taurus [GN:bta], Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9027-33-2
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