KEGG   ENZYME: 2.3.1.6Help
Entry
EC 2.3.1.6                  Enzyme                                 
Name
choline O-acetyltransferase;
choline acetylase;
choline acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:choline O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + choline = CoA + O-acetylcholine [RN:R01023]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
choline [CPD:C00114]
Product
CoA [CPD:C00010];
O-acetylcholine [CPD:C01996]
Comment
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.
Pathway
Glycerophospholipid metabolism
Orthology
K00623  
choline O-acetyltransferase
Genes
HSA: 
1103(CHAT)
PTR: 
450451(CHAT)
PPS: 
100976056(CHAT)
GGO: 
101129095(CHAT)
PON: 
100444631(CHAT)
MCC: 
709977(CHAT)
MMU: 
12647(Chat)
RNO: 
290567(Chat)
CFA: 
486775(CHAT)
AML: 
FCA: 
751512(CHAT)
BTA: 
524732(CHAT)
SSC: 
396896(CHAT)
ECB: 
100062632
MDO: 
100019640
OAA: 
100077991
GGA: 
395314(CHAT)
MGP: 
100543253
TGU: 
100231848(CHAT)
ACS: 
100558883
XTR: 
100485221
DRE: 
100170938(chat)
TRU: 
101061555
OLA: 
101156191
BFO: 
BRAFLDRAFT_211712
CIN: 
445622(chat)
SPU: 
574696(chat)
DME: 
Dmel_CG12345(Cha)
DPO: 
Dpse_GA11570
DAN: 
Dana_GF17123
DER: 
Dere_GG23058
DPE: 
Dper_GL24430
DSE: 
Dsec_GM17887
DSI: 
Dsim_GD19246
DWI: 
Dwil_GK13739
DYA: 
Dyak_GE25557
DGR: 
Dgri_GH18641
DMO: 
Dmoj_GI10809
DVI: 
Dvir_GJ14408
AGA: 
AgaP_AGAP002370
AAG: 
AaeL_AAEL010471
CQU: 
CpipJ_CPIJ001609
AME: 
408934
NVI: 
100121638(NV16479)
TCA: 
664403
API: 
100159222
PHU: 
Phum_PHUM569800
CBR: 
CBG08305(Cbr-cha-1)
BMY: 
Bm1_31295
SMM: 
Smp_146910
 » show all
Taxonomy
Reference
1  [PMID:13115440]
  Authors
BERMAN R, WILSON IB, NACHMANSOHN D.
  Title
Choline acetylase specificity in relation to biological function.
  Journal
Biochim. Biophys. Acta. 12 (1953) 315-24.
Reference
2  [PMID:13799882]
  Authors
BERRY JF, WHITTAKER VP.
  Title
The acyl-group specificity of choline acetylase.
  Journal
Biochem. J. 73 (1959) 447-58.
  Organism
pigeon
Reference
3  [PMID:14299645]
  Authors
FRITZ IB, SCHULTZ SK.
  Title
CARNITINE ACETYLTRANSFERASE. II. INHIBIITON BY CARNITINE ANALOGUES AND BY SULFHYDRYL REAGENTS.
  Journal
J. Biol. Chem. 240 (1965) 2188-92.
  Organism
Sus scofa [GN:ssc]
Reference
4
  Authors
Schuberth, J.
  Title
Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction.
  Journal
Biochim. Biophys. Acta 122 (1966) 470-481.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-78-6
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