KEGG   ENZYME: 2.3.1.74Help
Entry
EC 2.3.1.74                 Enzyme                                 
Name naringenin-chalcone synthase;
chalcone synthase;
flavanone synthase;
6'-deoxychalcone synthase;
chalcone synthetase;
DOCS;
CHS
Class Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Reaction(IUBMB) 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3
CO2 [RN:R01613]
Reaction(KEGG) R01613;
(other) R06568 R07987 R07988 R07989
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Substrate malonyl-CoA [CPD:C00083];
4-coumaroyl-CoA [CPD:C00223]
Product CoA [CPD:C00010];
naringenin chalcone [CPD:C06561];
CO2 [CPD:C00011]
Comment In the presence of NADH and a reductase, 6'-deoxychalcone is
produced.
Pathway PATH: ec00941  Flavonoid biosynthesis
PATH: ec01061  Biosynthesis of phenylpropanoids
PATH: ec01100  Metabolic pathways
Orthology KO: K00660  chalcone synthase
Genes ATH: AT5G13930(TT4)
POP: POPTR_554827(CHS4) POPTR_554829(CHS6) POPTR_572875(CHS1)
     POPTR_814871(CHS2)
RCU: RCOM_0561330 RCOM_1020600 RCOM_1444730
VVI: 100242903(GSVIVT00009241001) 100246143(GSVIVT00004047001)
     100254891(GSVIVT00009245001) 100262321(GSVIVT00007364001)
     100263437(GSVIVT00009234001) 100263443(GSVIVT00037967001)
     100266849(GSVIVT00009223001)
OSA: 4350636(Os11g0530600)
SBI: SORBI_02g034020(SORBIDRAFT_02g034020)
     SORBI_04g022590(SORBIDRAFT_04g022590)
     SORBI_05g019890(SORBIDRAFT_05g019890)
     SORBI_05g020150(SORBIDRAFT_05g020150)
     SORBI_05g020160(SORBIDRAFT_05g020160)
     SORBI_05g020170(SORBIDRAFT_05g020170)
     SORBI_05g022500(SORBIDRAFT_05g022500)
ZMA: 100274415(c2) 100282642
PPP: PHYPADRAFT_104998
PCS: Pc22g09640
SGL: SG2219
PAG: PLES_25771
PFL: PFL_5957
AVN: Avin_29530(arsC) Avin_29550(arsB)
PAR: Psyc_0421
PIN: Ping_0256
GBM: Gbem_1028
GEM: GM21_3232
DBA: Dbac_2112
BBA: Bd0331(bcsA)
ACP: A2cp1_0416
AFW: Anae109_4185
ANK: AnaeK_0415
SCL: sce2133(rppA) sce2182(chsA)
ARA: Arad_0992
RET: RHE_CH00744(ypch00249) RHE_PD00024(ypd00006)
REC: RHECIAT_CH0000823 RHECIAT_PB0000044
RLE: RL0786
RLT: Rleg2_0398
RLG: Rleg_0430
BRA: BRADO0151
BBT: BBta_0202
NHA: Nham_4105
MRD: Mrad2831_4712
MET: M446_5652
BID: Bind_2602 Bind_3897
MSL: Msil_3391
RSP: RSP_0226
RSH: Rsph17029_1868
RSK: RSKD131_1548
SWI: Swit_1186
RCE: RC1_1268(bcsA)
BSU: BSU22050(bcsA)
BHA: BH0617(bcsA)
BLD: BLi02345(bcsA)
BCL: ABC0998(bcsA)
BAY: RBAM_020200(bcsA)
BPU: BPUM_1941(bcsA)
OIH: OB1748
GKA: GK1551(bcsA)
GTN: GTNG_1402
GYM: GYMC10_2746
GYC: GYMC61_2390
AFL: Aflv_1363(bcsA)
LSP: Bsph_4432
BBE: BBR47_36650(bcsA)
HMO: HM1_0406(bcsA)
MTU: Rv1660(pks10) Rv1665(pks11)
MTC: MT1698 MT1705
MRA: MRA_1671(pks10) MRA_1676(pks11)
MTF: TBFG_11678 TBFG_11683
MTB: TBMG_02328(TBMG_02328.1) TBMG_02333(TBMG_02333.1)
MBO: Mb1688(pks10) Mb1693(pks11)
MBB: BCG_1699(pks10) BCG_1704(pks11)
MBT: JTY_1674(pks10) JTY_1679(pks11)
MPA: MAP1369(pks10) MAP1372(pks11)
MAV: MAV_3105 MAV_3110
MSM: MSMEG_0808
MUL: MUL_1656(pks11)
MVA: Mvan_1196
MGI: Mflv_5140
MMC: Mmcs_1059
MKM: Mkms_1075
MJL: Mjls_1086
MMI: MMAR_2470(pks10) MMAR_2474(pks11_1)
SCO: SCO7671(SC4C2.06c)
SMA: SAV_7131(rppA)
SGR: SGR_472(srsA) SGR_6620(rppA)
CMI: CMM_1534(chsA)
CMS: CMS_1773
ART: Arth_2198
AAU: AAur_2198
ACH: Achl_1939
KRH: KRH_07690
BFA: Bfae_04550
KSE: Ksed_00500
SRO: Sros_5949
FRA: Francci3_2458
FRE: Franean1_4396
FAL: FRAAL6460
NML: Namu_5115
KRA: Krad_2809
SEN: SACE_1243(rppA)
SVI: Svir_20410
STP: Strop_4264
SAQ: Sare_4694
CAI: Caci_2104
RXY: Rxyl_1084
ABA: Acid345_3105
ACA: ACP_3317
CHU: CHU_3794(bcsA)
CPI: Cpin_5033
PHE: Phep_1642
GFO: GFO_1610(bcsA)
FJO: Fjoh_3808
RBI: RB2501_14719
OTE: Oter_3635
MIN: Minf_2048(bcsA)
RBA: RB8853(chsA)
SYW: SYNW0993
SYE: Syncc9902_1339
SYG: sync_1460
SYX: SynWH7803_1003
CYC: PCC7424_2733
PMT: PMT0412
PMF: P9303_18741(bcsA)
CPH: Cpha266_1099
HAU: Haur_0021
DRA: DR_2091
DGE: Dgeo_1684
DDR: Deide_07890 Deide_21770
PMX: PERMA_1905
Taxonomy
Structures PDB: 1BI5  1BQ6  1CGK  1CGZ  1CHW  1CML  1D6F  1D6H  1D6I  1EE0  
     1I86  1I88  1I89  1I8B  1JWX  1QLV  1TED  1TEE  1U0V  1U0W  
     2P0U  3E1H  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:3355160]
Ayabe S, Udagawa A, Furuya T.
NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza
echinata cells induced by yeast extract.
Arch. Biochem. Biophys. 261 (1988) 458-62.
Glycyrrhiza echinata
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:7436427]
Heller W, Hahlbrock K.
Highly purified "flavanone synthase" from parsley
catalyzes the formation of naringenin chalcone.
Arch. Biochem. Biophys. 200 (1980) 617-9.
Petroselinum hotiense
Other DBs ExplorEnz - The Enzyme Database: 2.3.1.74
IUBMB Enzyme Nomenclature: 2.3.1.74
ExPASy - ENZYME nomenclature database: 2.3.1.74
BRENDA, the Enzyme Database: 2.3.1.74
CAS: 56803-04-4
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